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  1. 31201
    “…The identification and classification of these effects for data interpretation as well as the establishment of monitoring systems in the data collection process are pivotal. TRIAL REGISTRATION: DRKS00011930 (EMACROSS), DRKS00014273 (EMAAGE), NCT03188861 (EMASPOT) SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12874-023-01855-2.…”
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    Primary and secondary data in emergency medicine health services research – a comparative analysis in a regional research network on multimorbid patients
  2. 31202
    “…Neuroinflammation is central to the pathology progression, with evidence suggesting that microglia-released galectin-3 (gal3) plays a pivotal role by amplifying neuroinflammation in AD. …”
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    Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer’s disease
  3. 31203
    “…This sense of belonging is pivotal to new University students, indeed, without it, students are at greater risk of failing or withdrawing from their studies. …”
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    Impact of online learning on sense of belonging among first year clinical health students during COVID-19: student and academic perspectives
  4. 31204
    “…CONCLUSIONS: Our findings provide pivotal clues to understanding the role of the FOXA1-concerned ceRNA network in PCa. …”
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    Comprehensive analysis of the FOXA1-related ceRNA network and identification of the MAGI2-AS3/DUSP2 axis as a prognostic biomarker in prostate cancer
  5. 31205
    “…This post hoc analysis of a pivotal randomised CT-P13 SC 1.6 trial aimed to compare SC infliximab monotherapy with combotherapy in inflammatory bowel disease (IBD). …”
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    Subcutaneous Infliximab Monotherapy Versus Combination Therapy with Immunosuppressants in Inflammatory Bowel Disease: A Post Hoc Analysis of a Randomised Clinical Trial
  6. 31206
    “…Medial femoral rollback is reduced, however, with the joint pivoting around a rotational center located in the medial plateau. …”
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    Changes in femoral rollback and rotation with increasing coupling in knee arthroplasty—a biomechanical in-vitro study
  7. 31207
    “…Long noncoding RNAs (lncRNAs), widely expressed in mammalian cells, play pivotal roles in osteosarcoma (OS) progression. Nevertheless, the detailed molecular mechanisms of lncRNA KIAA0087 in OS remain obscure. …”
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    LncRNA KIAA0087 suppresses the progression of osteosarcoma by mediating the SOCS1/JAK2/STAT3 signaling pathway
  8. 31208
    “…T-cell-like VSMCs, macrophage-like VSMCs, and mesenchymal-like VSMCs play pivotal roles in this process. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01120-5.…”
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    Single-cell RNA sequencing reveals the vascular smooth muscle cell phenotypic landscape in aortic aneurysm
  9. 31209
    por Adane, Fentahun, Dessalegn, Megbar
    Publicado 2023
    “…Medical, surgical and public health measures are pivotal to reduce unfavorable management outcome in surgically treated intestinal obstruction patients in Ethiopia. …”
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    Magnitude and predictors of unfavorable management outcome in surgically treated patients with intestinal obstruction in Ethiopia: a systematic review and meta-analysis
  10. 31210
    por Chen, Zhao-jun, Xiao, Jie, Chen, Hai-hua
    Publicado 2023
    “…Moreover, these biomarkers were also closely associated with immune cell infiltration, which plays a pivotal role in the diagnosis and progression of COVID-19. …”
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    Identification of Key Genes Related to Immune Cells in Patients with COVID-19 Via Integrated Bioinformatics-Based Analysis
  11. 31211
    “…Furthermore, DEPs of eight chlorophyll a/b binding proteins, five ATPases and eight ribosomal proteins can play a pivotal role on chloroplast turnover and ATP metabolism. …”
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    Physiological and molecular response and tolerance of Macleaya cordata to lead toxicity
  12. 31212
    “…BACKGROUND: Genomics-informed pathogen surveillance strengthens public health decision-making, playing an important role in infectious diseases’ prevention and control. A pivotal outcome of genomics surveillance is the identification of pathogen genetic clusters and their characterization in terms of geotemporal spread or linkage to clinical and demographic data. …”
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    ReporTree: a surveillance-oriented tool to strengthen the linkage between pathogen genetic clusters and epidemiological data
  13. 31213
    “…DISCUSSION: In a previous phase III randomized, placebo-controlled pivotal trial, there were no significant differences in the prevalence of adverse events in patients receiving sotrovimab vs. placebo. …”
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    Safety and tolerability study of sotrovimab (VIR-7831) prophylaxis against COVID-19 infection in immunocompromised individuals with impaired SARS-CoV-2 humoral immunity
  14. 31214
    “…AIMS: Neutrophils play a pivotal in immunity and inflammation. We aim to investigate the prevalence of neutropenia in the United States. …”
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    Prevalence of neutropenia in US residents: a population based analysis of NHANES 2011–2018
  15. 31215
    “…Glioma-associated macrophages (GAMs) are pivotal chains in the tumor immune microenvironment (TIME). …”
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    MiR-146a-5p deficiency in extracellular vesicles of glioma-associated macrophages promotes epithelial-mesenchymal transition through the NF-κB signaling pathway
  16. 31216
    “…Such significant elevation of endogenous FSH levels was observed to be related to pivotal events in the transition from mitosis to meiosis, as reflected by the proportion of oogonia during premeiosis interphase, with endogenous FSH levels reaching a peak at the earliest time step of 1 dph. …”
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    The effects of endogenous FSH and its receptor on oogenesis and folliculogenesis in female Alligator sinensis
  17. 31217
    por Bayati, Mohsen, Kiadaliri, Ali
    Publicado 2023
    “…BACKGROUND: Public health policies and healthcare quality play a pivotal role on the health outcome level and disparities across sociodemographic groups. …”
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    Contributions of avoidable mortality to the sex gap in life expectancy and life disparity in Iran
  18. 31218
    “…This is because they may hold pivotal central roles in the broader network of bacterial taxa (e.g., Bifidobacterium and Massilia). …”
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    Exploring Co-occurrence patterns and microbial diversity in the lung microbiome of patients with non-small cell lung cancer
  19. 31219
    “…The Health Technology Assessment Regulation plans for Joint Scientific Consultations for specific high-risk devices before companies begin their pivotal clinical investigations. The demanded comparative evidence should facilitate payer decisions. …”
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    Gaps in the evidence underpinning high-risk medical devices in Europe at market entry, and potential solutions
  20. 31220
    “…BACKGROUND: Long terminal repeat (LTR)-retrotransposons (LTR-RTs) are ubiquitous and make up the majority of nearly all sequenced plant genomes, whereas their pivotal roles in genome evolution, gene expression regulation as well as their epigenetic regulation are still not well understood, especially in a large number of closely related species. …”
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    Lineage-specific amplification and epigenetic regulation of LTR-retrotransposons contribute to the structure, evolution, and function of Fabaceae species
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