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  1. 31461
    “…ABSTRACT: Tumour necrosis factor alpha (TNFα) is a multifunctional cytokine that plays a pivotal role in apoptosis, cell survival, as well as in inflammation and immunity. …”
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    Inhibition of RNA Polymerase III Augments the Anti-Cancer Properties of TNFα
  2. 31462
    “…The entorhinal cortex is a pivotal region that, along with the hippocampus, plays a critical role in memory in the Alzheimer’s disease (AD) pathology process. …”
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    Selective Targeting of Class I HDAC Reduces Microglial Inflammation in the Entorhinal Cortex of Young APP/PS1 Mice
  3. 31463
    “…In conclusion, we demonstrated that aggrecan is pivotal for the determination and maintenance of the proper stiffness of IVD and vertebral tissues, which in turn could play an essential role in providing developmental biomechanical cues.…”
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    Aggrecan governs intervertebral discs development by providing critical mechanical cues of the extracellular matrix
  4. 31464
    “…Identification of factors associated with SBI is pivotal for intervening with appropriate programmes to reduce occurrence of SBI and associated adverse consequences. …”
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    Prevalence and risk factors of short birth interval in Bangladesh: Evidence from the linked data of population and health facility survey
  5. 31465
    “…Objective: Diminished physical capacity is common and progressive in patients undergoing dialysis, who are also prone to deficiency in carnitine, which plays a pivotal role in maintaining skeletal muscle and cardiac function. …”
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    Correlation between acylcarnitine/free carnitine ratio and cardiopulmonary exercise test parameters in patients with incident dialysis
  6. 31466
    “…OBJECTIVE: Serdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) is approved for the treatment of patients aged ≥6 years with attention-deficit/hyperactivity disorder (ADHD). A pivotal double-blind (DB) study of children aged 6–12 years with ADHD demonstrated efficacy for ADHD with good tolerability. …”
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    Safety and Tolerability of Serdexmethylphenidate/Dexmethylphenidate Capsules in Children with Attention-Deficit/Hyperactivity Disorder: A 12-Month, Open-Label Safety Study
  7. 31467
    “…AIMS: Recovery of blood flow is a therapeutic approach for myocardial infarction but paradoxically induces injury to the myocardium. Exosomes (exos) are pivotal mediators for intercellular communication that can be released by different cells and are involved in cardiovascular diseases. …”
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    MicroRNA‐155‐5p in serum derived‐exosomes promotes ischaemia–reperfusion injury by reducing CypD ubiquitination by NEDD4
  8. 31468
    “…In addition, we show that GUN1 plays a role in appressorium functioning. The pivotal role of GUN1, the ortholog of Pth2, in ascospore germination and in appressorium functioning reinforces the idea of a common genetic regulation governing both appressorium development and melanized ascospore germination. …”
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    GUN Mutants: New Weapons To Unravel Ascospore Germination Regulation in the Model Fungus Podospora anserina
  9. 31469
    “…BACKGROUND: Pregnancy represents a state of increased oxidative stress and antioxidants, in which selenium (Se) plays a pivotal role, contribute to maintain the oxidative balance. …”
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    Selenium status in term neonates, according to birth weight and gestational age, in relation to maternal hypertensive pathology
  10. 31470
    “…GFI1 is a transcriptional repressor and plays a pivotal role in regulating the differentiation of hematopoietic stem cells (HSCs) towards myeloid and lymphoid cells. …”
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    Dose-dependent effect of GFI1 expression in the reconstitution and the differentiation capacity of HSCs
  11. 31471
    “…Classification of TEX molecular phenotypes is pivotal to overcoming TEX and improving immunotherapies in the clinical setting. …”
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    Cuproptosis-related molecular subtypes direct T cell exhaustion phenotypes and therapeutic strategies for patients with lung adenocarcinoma
  12. 31472
    “…SIMPLE SUMMARY: Vaccines play a pivotal role in the control of infectious diseases. …”
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    Immunogenicity and Efficacy of a Feed-Based Bivalent Vaccine against Streptococcosis and Motile Aeromonad Septicemia in Red Hybrid Tilapia (Oreochromis sp.)
  13. 31473
    “…CONCLUSIONS: Circulating cardiac miRNA‐FOXO3 axis plays a pivotal role in safeguarding against myocardial apoptosis and excessive autophagy in DCM development, which may provide serological cues for DCM non‐invasive diagnosis and shed light on DCM pathogenesis and therapeutic targets.…”
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    Circulating cardiac MicroRNAs safeguard against dilated cardiomyopathy
  14. 31474
    “…Airway epithelial cells play a pivotal role in the development of asthma, and mitochondria dysfunction is involved in the pathogenesis of asthma. …”
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    Mitochondria dysfunction in airway epithelial cells is associated with type 2-low asthma
  15. 31475
    “…This study reveals possible pivotal genes and metabolic pathways for sugar beet adaptation to nitrogen-deficient environments.…”
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    Low nitrogen stress-induced transcriptome changes revealed the molecular response and tolerance characteristics in maintaining the C/N balance of sugar beet (Beta vulgaris L.)
  16. 31476
    “…OBJECTIVE: Long non-coding RNAs (lncRNAs) play pivotal roles in the transcriptional regulation of atrial fibrillation (AF) by acting as competing endogenous RNAs (ceRNAs). …”
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    Integrated analysis of the lncRNA-miRNA-mRNA network based on competing endogenous RNA in atrial fibrillation
  17. 31477
    “…The lack of appropriate risk-stratification tools at hospital discharge of AHF patients significantly limits clinical ability to precisely tailor patient-specific therapeutic regimen at this pivotal juncture. Machine learning-based strategies may improve risk stratification by incorporating analysis of high-dimensional patient data with multiple covariates and novel prediction methodologies. …”
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    What drives performance in machine learning models for predicting heart failure outcome?
  18. 31478
    “…GINS3 genetic alteration, gene-gene interaction, PPI networks, and enrichment analysis further revealed that GINS3 played a pivotal role in the progression of LIHC. Furthermore, hypermethylation of GINS3 at different cytosine-guanine (CpG) sites was correlated with better or worse overall survival (OS) in LIHC and GINS3 was also closely correlated with m6A modification. …”
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    A novel prognostic biomarker: GINS3 is correlated with methylation and immune escape in liver hepatocellular carcinoma
  19. 31479
    “…Neutralizing antibodies play a pivotal role in protecting piglets from enteric infections. …”
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    Correlation between the IgG/IgA Antibody Response against PEDV Structural Protein and Virus Neutralization
  20. 31480
    “…Taken together, we demonstrated that BDE2 plays a pivotal role for hippocampal neurogenesis, as well as learning and memory during female aging, especially in juvenile and middle age.…”
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    Brain-Derived Estrogen Regulates Neurogenesis, Learning and Memory with Aging in Female Rats
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