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  1. 31481
    “…Our findings suggest that peripheral inflammation plays a pivotal role in the NPS cluster over cancer treatment, including long-term follow-ups. …”
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    Associations of inflammation with neuropsychological symptom cluster in patients with Head and neck cancer: A longitudinal study
  2. 31482
    “…INTRODUCTION: Ixekizumab has demonstrated efficacy in pivotal trials in patients with psoriatic arthritis (PsA), both those naïve to prior biologic therapy and those with prior inadequate response or intolerance to biologics; however, minimal information is currently available on the effectiveness of ixekizumab in routine clinical practice. …”
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    Changes in musculoskeletal disease activity and patient-reported outcomes in patients with psoriatic arthritis treated with ixekizumab: results from a real-world US cohort
  3. 31483
    “…CONCLUSION: Mechanical and NO-dependent microvascular dysfunction seem to play a pivotal role in residual hearing loss after CI electrode array insertion. …”
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    Cochlear implantation impairs intracochlear microcirculation and counteracts iNOS induction in guinea pigs
  4. 31484
    “…The glycocalyx plays a pivotal role in endothelial function and is involved in many processes including binding of chemokines and cytokines, leukocyte trafficking, and preventing proteinuria. …”
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    Glycosaminoglycans and fucoidan have a protective effect on experimental glomerulonephritis
  5. 31485
    “…Background: Solute Carrier Family 3 Member 2 (SLC3A2) is a member of the solute carrier family that plays pivotal roles in regulation of intracellular calcium levels and transports L-type amino acids. …”
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    Integrated analysis of FKBP1A/SLC3A2 axis in everolimus inducing ferroptosis of breast cancer and anti-proliferation of T lymphocyte
  6. 31486
    “…Two brain regions were studied, the hippocampus and neocortex, both of which are pivotal for cognitive function. Indeed, numerous differences were identified, which are not only mouse strain (genotype)-specific but also brain-region-specific. …”
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    Mitochondrial Proteome Changes in Rett Syndrome
  7. 31487
    “…OBJECTIVES: The primary endpoint of the pivotal phase III study of infliximab (IFX) s.c. demonstrated non-inferiority of s.c. to i.v. …”
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    Efficacy of subcutaneous vs intravenous infliximab in rheumatoid arthritis: a post-hoc analysis of a randomized phase III trial
  8. 31488
    “…Simulation modeling was performed on 3 patient cohorts—those with a baseline hemoglobin A1c of 8% to < 9%, 9% to < 10%, and ≥ 10%—to estimate long-term cost and clinical outcomes using modeling based on pivotal trial data (the Archimedes Model). A sensitivity analysis was conducted to assess the extent to which our results were dependent on assumptions related to program effectiveness and costs. …”
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    Development of a Pharmacoeconomic Model to Demonstrate the Effect of Clinical Pharmacist Involvement in Diabetes Management
  9. 31489
    por Liu, Wenjie, Huo, Gengwei, Chen, Peng
    Publicado 2023
    “…When new combination therapies with remarkable effect become pivotal in the first-line treatment, the price reduction of durvalumab and tremelimumab may be necessary to achieve cost-effectiveness in future possible context.…”
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    First-line tremelimumab plus durvalumab and chemotherapy versus chemotherapy alone for metastatic non-small cell lung cancer: a cost-effectiveness analysis in the United States
  10. 31490
    “…Oxidative stress has been documented to serve a pivotal role in DOX-induced cardiomyopathy. Previous studies have reported that 1,25(OH)(2)D(3) has antioxidant and anti-inflammatory effects and can inhibit the renin-angiotensin system. …”
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    1,25(OH)(2)D(3) ameliorates doxorubicin‑induced cardiomyopathy by inhibiting the NLRP3 inflammasome and oxidative stress
  11. 31491
    “…With high vaccine uptake, anti-Spike (S) reactivity rates reached >80% by May 2021, and the study pivoted from reflex Roche anti-nucleocapsid (NC) testing of Ortho S-reactive specimens to parallel Ortho S/NC testing. …”
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    Evaluation of Ortho VITROS and Roche Elecsys S and NC Immunoassays for SARS-CoV-2 Serosurveillance Applications
  12. 31492
    “…Performance in cutting and/or pivoting sports was negatively associated with RTS.…”
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    Return to Sport After Multiligament Knee Injury in Young Athletes
  13. 31493
    “…The paper suggests that RET is pivotally important for mitochondrial energy homeostasis by controlling oxidative phosphorylation by switching between activation and inactivation of glycolysis and regulation of electron flux in the electron transport chain. …”
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    Control of Mitochondrial Electron Transport Chain Flux and Apoptosis by Retinoic Acid: Raman Imaging In Vitro Human Bronchial and Lung Cancerous Cells
  14. 31494
    “…Tropical forests on karstic relief (tropical karst forest) are among the most species-rich biomes. These forests play pivotal roles as global climate regulators and for human wellbeing. …”
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    How diverse are the mountain karst forests of Mexico?
  15. 31495
    “…Binding affinity and functional activity are pivotal parameters for development and characterization of new GH analogues for treatment of growth disorders. …”
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    THU048 Determination Of Receptor Binding Affinity Of Growth Hormone Analogues To The Growth Hormone Receptor In A Drug Screening Context
  16. 31496
    “…Early diagnosis of the condition is pivotal for close cancer surveillance and management. …”
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    THU533 Cowden Syndrome: A Rare Disease With A Lasting Impact
  17. 31497
    “…METHODS AND RESULTS: In this cross‐sectional survey, we investigated the price, affordability, and accessibility of four pivotal classes of HFrEF GDMT: angiotensin‐converting enzyme inhibitors (ACEi), angiotensin receptor blockers (ARB) or angiotensin‐neprilysin inhibitors (ARNI); beta‐blockers; mineralocorticoid receptor antagonists (MRA); and sodium glucose co‐transporter 2 inhibitors (SGLT2i). …”
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    Pharmaco‐disparities in heart failure: a survey of the affordability of guideline recommended therapy in 10 countries
  18. 31498
    “…The misuse of antibiotics has led to the emergence of antibiotic resistance, and residues in the human food chain may appear. It is pivotal for the swine industry to seek feed additives that can contribute to the health of the gastrointestinal tract. …”
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    Effects of Lactobacillus rhamnosus DSM7133 on Intestinal Porcine Epithelial Cells
  19. 31499
    “…Comprehensive preoperative assessment, meticulous surgical techniques, and precise radiographic imaging play pivotal roles in successful management. Adhering to established protocols is imperative to mitigate potential complications and ensure optimal outcomes. …”
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    A rare case of mandibular third molar displaced into submandibular space: A complication of mandibular third molar extraction
  20. 31500
    “…Highlighting the indispensable role of radiation oncologists (ROs) in this process, the paper delves into pivotal phases such as CT simulation, treatment target and organs at risk (OAR) delineation, and acute toxicity management. …”
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    A Comprehensive Primer on Radiation Oncology for Non-Radiation Oncologists
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