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  1. 31641
    “…At the brain surfaces, gadobutrol propagated antegradely along large leptomeningeal arteries in all study subjects, and preceded glymphatic enhancement in adjacent brain tissue, indicating a pivotal role of intracranial pulsations for glymphatic function. …”
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    Glymphatic MRI in idiopathic normal pressure hydrocephalus
  2. 31642
    “…Outcomes: Nine studies were critically analysed, and 42 different miRNAs were found to be dysregulated in them, with only one common miRNA (miR-20a) differentially expressed in more than one study. miR-17-5p/20a, miR-200, miR-199a, miR-143, and miR-145 were explored for their pivotal role in the aetiopathogenesis of endometriosis. …”
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    The miRNA Mirage: How Close Are We to Finding a Non-Invasive Diagnostic Biomarker in Endometriosis? A Systematic Review
  3. 31643
    “…When epigenetic changes were leveraged with gene expression, the pivotal TFs ATF3 and FOS were defined with ATF3 also cross-referencing with gene expression-identified TFs. …”
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    Overall Downregulation of mRNAs and Enrichment of H3K4me3 Change Near Genome-Wide Association Study Signals in Systemic Lupus Erythematosus: Cell-Specific Effects
  4. 31644
    “…METHODS: A possible starting point for the treatment could be pharmacological activation of voltage gated sodium channels (Nav) which have a pivotal role in action potential initiation. Of the four subtypes of Nav channels expressed in the CNS Nav 1.1 comprises the majority of the sodium current in FS-PV+ but not in pyramidal neurons. …”
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    T76. INVESTIGATION OF NAV1.1 POSITIVE MODULATOR EFFECTS ON FAST SPIKING INTERNEURONS IN SOMATOSENSORY CORTEX SLICES
  5. 31645
    “…Against this background, it is of pivotal importance to investigate the precise mechanisms that underlie such association, and evaluate the potential beneficial and/or detrimental impact of pharmacological treatment during pregnancy and the postpartum period. …”
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    T37. THE LONELY MOUSE: A MODEL FOR STUDYING MATERNAL PSYCHOLOGICAL STRESS AND ITS CONSEQUENCES IN THE OFFSPRING
  6. 31646
    “…BACKGROUND: Nurse managers have a pivotal role in fostering unit climates supportive of implementing evidence-based practices (EBPs) in care delivery. …”
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    Associations among unit leadership and unit climates for implementation in acute care: a cross-sectional study
  7. 31647
    “…Further studies showed that the expression of several pivotal anther-related miRNAs was altered in 337S at SL condition, especially tae-miR1127a, which may be related to male sterility of 337S. …”
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    Transcriptome analysis reveals new microRNAs-mediated pathway involved in anther development in male sterile wheat
  8. 31648
    “…DISCUSSION: This prospective, observational, noninterventional, multicenter study for the first time investigates the performance as well as the clinical value of a NGS-based approach for the detection of bacteremia in patients with sepsis and may therefore be a pivotal step toward the clinical use of NGS in this indication. …”
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    Next-generation sequencing diagnostics of bacteremia in sepsis (Next GeneSiS-Trial): Study protocol of a prospective, observational, noninterventional, multicenter, clinical trial
  9. 31649
    “…However, the analyzed movement was a straight-ahead run without any cutting or pivoting maneuvers commonly related to ACL tears. In such motion patterns, the correlations may be even stronger compared to the results of this study.…”
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    The difference between the medial and lateral posterior tibial slope is associated with greater internal tibial rotation
  10. 31650
    “…The selection of accurate LQ parameters α, β and α/β is pivotal for a reliable estimate of radiation response. …”
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    The alfa and beta of tumours: a review of parameters of the linear-quadratic model, derived from clinical radiotherapy studies
  11. 31651
    “…Histone deacetylase 3 (HDAC3) plays a pivotal role in the repression of cartilage-specific gene expression in human chondrocytes. …”
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    MicroRNA-193b-3p regulates chondrogenesis and chondrocyte metabolism by targeting HDAC3
  12. 31652
    “…The study points to a need for appropriate patient education and counselling with regards medicines, improved coordination between hospital staff, and provision of some basic system-related facilities which are pivotal for enhancing patients’ knowledge and adherence to their treatment regimens.…”
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    Factors affecting patients’ knowledge about dispensed medicines: A Qualitative study of healthcare professionals and patients in Pakistan
  13. 31653
    “…The host’s immune system plays a pivotal role in many tumor types, including squamous cell carcinomas (SCCs). …”
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    The Prognostic Value of Immune Factors in the Tumor Microenvironment of Penile Squamous Cell Carcinoma
  14. 31654
    “…Neuroinflammation plays a pivotal role in the pathogenesis of chronic migraine (CM). …”
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    α7 Nicotinic acetylcholine receptor-mediated anti-inflammatory effect in a chronic migraine rat model via the attenuation of glial cell activation
  15. 31655
    “…METHODS: We used data collected in the first 26 weeks of the lomitapide pivotal phase 3 study (NCT00730236) to evaluate achievement of European Atherosclerosis Society (EAS) LDL-C targets. …”
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    Target achievement and cardiovascular event rates with Lomitapide in homozygous Familial Hypercholesterolaemia
  16. 31656
    “…These findings suggest that miR-125a-5p may play a pivotal role in the development and progression of ESCC, which may be achieved via the manipulation of the STAT3 signaling pathway.…”
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    MicroRNA-125a-5p enhances the sensitivity of esophageal squamous cell carcinoma cells to cisplatin by suppressing the activation of the STAT3 signaling pathway
  17. 31657
    “…Bacterial biofilm plays a pivotal role in bioremediation of heavy metals from wastewaters. …”
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    Metal-Adapted Bacteria Isolated From Wastewaters Produce Biofilms by Expressing Proteinaceous Curli Fimbriae and Cellulose Nanofibers
  18. 31658
    “…Taken together, the results of our study reveal the importance of cytomegaloviral interferon antagonism for viral replication as well as a pivotal role of the remaining STAT2 activity for host survival. …”
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    STAT2-Dependent Immune Responses Ensure Host Survival despite the Presence of a Potent Viral Antagonist
  19. 31659
    “…This manuscript describes three pivotal laboratory studies assessing the efficacy and speed of kill of lotilaner in cats against Ixodes ricinus ticks following a single oral administration, at a dose rate close to 6 mg/kg. …”
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    Laboratory evaluation of the efficacy and speed of kill of lotilaner (Credelio(TM)) against Ixodes ricinus ticks on cats
  20. 31660
    “…BACKGROUND: Dendritic cells (DCs) are unique antigen presenting cells (APC) which play a pivotal role in immunotherapy and induction of an effective immune response against tumors. …”
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    Dendritic cells pulsed with generated tumor cell lysate from Phyllanthus amarus Schum. & Thonn. induces anti-tumor immune response
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