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  1. 31841
    “…Angiotensin converting enzyme-2 (ACE2) and associated proteins play a pivotal role in various physiological and pathological events, such as immune activation, inflammation, gut barrier maintenance, intestinal stem cell proliferation, and apoptosis. …”
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    Simian Immunodeficiency Virus Infection Mediated Changes in Jejunum and Peripheral SARS-CoV-2 Receptor ACE2 and Associated Proteins or Genes in Rhesus Macaques
  2. 31842
    “…Albeit mL1 enzymes are less active than L1 ones, Bacteroides likely plays a pivotal role in the deglucuronidation, due to its remarkable abundance in the microbiomes. …”
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    β-Glucuronidase Pattern Predicted From Gut Metagenomes Indicates Potentially Diversified Pharmacomicrobiomics
  3. 31843
    “…Cell surface receptors and their interactions with virus coat proteins are a crucial step for oncolytic virus entry and a pivotal determinant. The L5 proteins of the virus coat are the first to interact with host cell surface receptors. …”
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    Interaction Analysis of Adenovirus L5 Protein With Pancreatic Cancer Cell Surface Receptor to Analyze Its Affinity for Oncolytic Virus Therapy
  4. 31844
    “…Human genetic factors, including polymorphisms, serve pivotal roles in the high transmission of SARS-CoV-2 and the stubbornly progressing sickness seen in a small but significant percentage of infected people; however, but these factors remain ill-defined. …”
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    Association of TMPRSS2 Gene Polymorphisms with COVID-19 Severity and Mortality: a Case-Control Study with Computational Analyses
  5. 31845
    “…CONCLUSIONS: The economic impact associated with organ damage in patients with SLE is profound and reducing or preventing organ damage will be pivotal in alleviating the burden for patients and healthcare providers.…”
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    An evaluation of costs associated with overall organ damage in patients with systemic lupus erythematosus in the United States
  6. 31846
    “…CONCLUSIONS: Moderate-intensity statin therapy is pivotal for the attainment of optimal LDL-C goals in China, and around 10–25% of high- or very-high-risk patients would require additional non-statin agents. …”
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    Atherosclerotic Cardiovascular Disease Risk and Lipid-Lowering Therapy Requirement in China
  7. 31847
    “…These findings reveal SMURF2 as a pivotal regulator of KAP1, laying a foundation for the investigation of the role of the SMURF2–KAP1 axis in carcinogenic processes and therapeutic responses to anticancer treatment. …”
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    The Emerging Role of E3 Ubiquitin Ligase SMURF2 in the Regulation of Transcriptional Co-Repressor KAP1 in Untransformed and Cancer Cells and Tissues
  8. 31848
    “…More interestingly, we found latitudinal variations in the TSD pattern in terms of pivotal temperatures (T(piv)s), transitional range of temperatures (TRT), and the sex ratios at the medium temperatures. …”
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    Latitudinal Variation in the Pattern of Temperature-Dependent Sex Determination in the Japanese Gecko, Gekko japonicus
  9. 31849
    “…Lung inflammation is a pivotal event in the pathogenesis of acute lung injury. …”
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    HO-1 Upregulation by Kaempferol via ROS-Dependent Nrf2-ARE Cascade Attenuates Lipopolysaccharide-Mediated Intercellular Cell Adhesion Molecule-1 Expression in Human Pulmonary Alveolar Epithelial Cells
  10. 31850
    “…IMPORTANCE: An international comparison of pediatric outpatient prescriptions (POPs) is pivotal to investigate inadequate practices at the national scale and guide corrective actions. …”
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    Pediatric Outpatient Prescriptions in Countries With Advanced Economies in the 21st Century: A Systematic Review
  11. 31851
    “…Furthermore, despite HMT-352 strains sharing a majority of their genes, we identified several gene clusters that may play a pivotal role in host affinity. More importantly, our comparative analyses also provide TM7 gene candidates associated with strain-level phenotypic variation that may be important for episymbiotic interactions with host bacteria. …”
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    Strain-Level Variation and Diverse Host Bacterial Responses in Episymbiotic Saccharibacteria
  12. 31852
    “…Thus, the LTP-infected stallions play a pivotal role in maintaining and perpetuating EAV in the equine population. …”
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    Development of a TaqMan(®) Allelic Discrimination qPCR Assay for Rapid Detection of Equine CXCL16 Allelic Variants Associated With the Establishment of Long-Term Equine Arteritis Virus Carrier State in Stallions
  13. 31853
    “…CLINICAL TRIAL REGISTRATION: EudraCT 2021-000349-42 LAY SUMMARY: T cells are a pivotal component in the defence against viruses. …”
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    Impaired SARS-CoV-2-specific T-cell reactivity in patients with cirrhosis following mRNA COVID-19 vaccination
  14. 31854
    “…Increasing evidence indicate that alternative splicing (AS) plays a pivotal role in sugar signaling. However, the regulatory mechanism upon glucose stress remains unclear. …”
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    Alternative Splicing Regulation of Glycine-Rich Proteins via Target of Rapamycin-Reactive Oxygen Species Pathway in Arabidopsis Seedlings Upon Glucose Stress
  15. 31855
    “…The management of livestock movement patterns plays a pivotal role in the sustainable use of silvopastoral systems. …”
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    Spatial Distribution and Habitat Selection of Sarda Cattle in a Silvopastoral Mediterranean Area
  16. 31856
    “…BACKGROUND: Adequate nutritional intake plays a pivotal role in optimizing performance, recovery, and body composition goals. …”
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    Dietary Intakes, Knowledge, and Perceptions of Semi-professional Rugby Athletes in Scotland
  17. 31857
    “…Structure-based mutagenesis studies revealed critical residues involved in a candidate RNA binding region, which also play pivotal roles in complex with InsP(6). Notably, InsP(6) can inhibit g5Rp activity by competitively blocking the binding of substrate mRNA to the enzyme. …”
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    Structural Insight into Molecular Inhibitory Mechanism of InsP(6) on African Swine Fever Virus mRNA-Decapping Enzyme g5Rp
  18. 31858
    “…The correlation between intravesical levels of HMGB1 and bladder pain indicates that released HMGB1 is pivotal to bladder pain. Thus, modulating events in the MIF signaling cascade triggered by PAR4 activation (including bladder oxidative stress and HMGB1 release) warrant further investigation as possible therapeutic strategies.…”
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    Bladder Oxidative Stress and HMGB1 Release Contribute to PAR4-Mediated Bladder Pain in Mice
  19. 31859
    “…SIMPLE SUMMARY: Gonadotropin-releasing hormone (GnRH) plays a pivotal role in fish reproduction. In the present study, transcription activator-like effector nuclease (TALEN) plasmids targeting the catfish gonadotropin-releasing hormone (cfGnRH) gene were delivered into fertilized eggs with double electroporation to sterilize channel catfish (Ictalurus punctatus). …”
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    Gene Editing of the Catfish Gonadotropin-Releasing Hormone Gene and Hormone Therapy to Control the Reproduction in Channel Catfish, Ictalurus punctatus
  20. 31860
    “…Previous studies have reported m(6)A can determine mRNA fate and play a pivotal role in tumour development and progression. …”
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    ZNF677 suppresses renal cell carcinoma progression through N6‐methyladenosine and transcriptional repression of CDKN3
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