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  1. 31901
    “…BACKGROUND: Systemic hypoperfusion plays a pivotal role in the pathogenesis of primary open-angle glaucoma (POAG). …”
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    Progression of functional and structural glaucomatous damage in relation to diurnal and nocturnal dips in mean arterial pressure
  2. 31902
    “…CONCLUSION: Taken together, we demonstrate that SMRT functions as a pivotal transcriptional mediator for both β-oxidation and the prevention for the fibrosis via TGF-β receptor signaling in the differentiation of C2C12 myoblasts. …”
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    Nuclear corepressor SMRT acts as a strong regulator of both β-oxidation and suppressor of fibrosis in the differentiation process of mouse skeletal muscle cells
  3. 31903
    “…Clinical and cell-based studies as well as investigations on mice have demonstrated pivotal roles for each SRC in numerous physiological and pathophysiological contexts, underscoring their functional pleiotropy. …”
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    Decidualization of human endometrial stromal cells requires steroid receptor coactivator-3
  4. 31904
    “…Plasma membrane (PM) H(+)-ATPase in guard cells plays a pivotal role for light-induced stomatal opening. In contrast, stomata close in response to the dark or plant hormone abscisic acid (ABA). …”
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    Tryptophan synthase ß subunit 1 affects stomatal phenotypes in Arabidopsis thaliana
  5. 31905
    “…This study was designed to screen autophagy-related genes (ATGs) that may play a pivotal role in PCOS, providing potential biomarkers and identifying new molecular subgroups for therapeutic intervention. …”
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    Polycystic ovary syndrome: Identification of novel and hub biomarkers in the autophagy-associated mRNA-miRNA-lncRNA network
  6. 31906
    “…However, pregnant people were not included in pivotal phase III COVID-19 vaccine efficacy trials. …”
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    2297. COVID-19 Vaccine Effectiveness Among Pregnant People
  7. 31907
    “…Background: Neuroinflammation plays a pivotal role in the pathogenesis of Central Nervous System (CNS) diseases. …”
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    Gastrodin ameliorates the lipopolysaccharide-induced neuroinflammation in mice by downregulating miR-107-3p
  8. 31908
    “…METHODS: FSFI data pooled from 3 pivotal flibanserin trials in premenopausal women (flibanserin = 1,165; placebo = 1,203) and FSFI data from one complete flibanserin trial in postmenopausal women (flibanserin = 432; placebo = 463) were subjected to post-hoc analyses. …”
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    Effects of Flibanserin on Subdomain Scores of the Female Sexual Function Index in Women With Hypoactive Sexual Desire Disorder
  9. 31909
    “…It has been confirmed that the plant-specific Teosinte-branched 1/Cycloidea/Proliferating (TCP) gene family plays a pivotal role during plant growth and development. …”
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    Genome-Wide Identification and Characterization of TCP Gene Family Members in Melastoma candidum
  10. 31910
    “…Being the drug experts, pharmacists are in a pivotal position to delivered tailored education to their peers, the nurses. …”
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    A specialized training program on inhaler technique delivered by pharmacists to nurses: a study from the United Arab Emirates
  11. 31911
    “…Five themes were identified, including the pivotal role of inflammation caused by intestinal bacteria in the rheumatic pathogenesis, the close relationship between rheumatic diseases and inflammatory bowel disease, immunoregulation mechanism as a mediator of the interaction between rheumatic diseases and gut flora, dysbiosis and decreased diversity in intestine of patients with rheumatic diseases, and the influence of oral flora on rheumatic diseases. …”
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    Effects of intestinal microbes on rheumatic diseases: A bibliometric analysis
  12. 31912
    por Bian, Rutao, Xu, Xuegong, Li, Weiyu
    Publicado 2023
    “…These common pathways and pivotal genes may provide new ideas for further clinical treatment and experimental studies.…”
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    Uncovering the molecular mechanisms between heart failure and end-stage renal disease via a bioinformatics study
  13. 31913
    “…BACKGROUND: Calcitonin gene-related peptide (CGRP) plays a pivotal role in migraine physiology, not only regarding migraine pain but also associated symptoms such as photophobia. …”
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    Photophobia and migraine outcome during treatment with galcanezumab
  14. 31914
    “…Additionally, it is crucial for appetite, weight, and metabolic control and plays a pivotal role in the cardiovascular system. The Val66Met polymorphism (rs6265) of the BDNF gene causes a decrease in BDNF secretion and plays a role in impairments in cognition, energy homeostasis, and cardiovascular events. …”
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    Association of BDNF gene missense polymorphism rs6265 (Val66Met) with three quantitative traits, namely, intelligence quotient, body mass index, and blood pressure: A genetic association analysis from North India
  15. 31915
    “…Thermal stress during the first week after hatch alters proliferation, myogenesis, and adipogenesis of SCs of turkey pectoralis major (p. major) muscle via mechanistic target of rapamycin (mTOR) and wingless-type mouse mammary tumor virus integration site family/planar cell polarity (Wnt/PCP) pathways. Pivotal genes in mTOR and Wnt/PCP pathways are mTOR and frizzled-7 (Fzd7), respectively. …”
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    Differential effects of temperature and mTOR and Wnt-planar cell polarity pathways on syndecan-4 and CD44 expression in growth-selected turkey satellite cell populations
  16. 31916
    “…Recent evidence suggests that transfer ribonucleic acid (tRNA)-derived fragments play pivotal roles in the occurrence and development of various tumors. …”
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    Exosome-Transmitted tRF-16-K8J7K1B Promotes Tamoxifen Resistance by Reducing Drug-Induced Cell Apoptosis in Breast Cancer
  17. 31917
    “…Solution small-angle X-ray scattering (SAXS) data-steered model building confirmed that the C-terminal region plays a pivotal role in dimer formation. Systematic evolution of ligands by exponential enrichment (SELEX) resulted in the identification of single-strand DNA (ssDNA) aptamers that can be used as a tool to identify small-molecule inhibitors targeting Rv0792c. …”
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    Structural and Functional Characterization of Rv0792c from Mycobacterium tuberculosis: Identifying Small Molecule Inhibitor against HutC Protein
  18. 31918
    “…These results indicated that the activities of aurora kinases play pivotal roles in the life cycles of diverse viruses. …”
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    Inhibitors of One or More Cellular Aurora Kinases Impair the Replication of Herpes Simplex Virus 1 and Other DNA and RNA Viruses with Diverse Genomes and Life Cycles
  19. 31919
    “…CONCLUSION: Early induction of inflammatory cytokines may not be pivotal for accelerated FLR regeneration after ALPPS, whereas Akt-eNOS pathway activation may contribute to accelerated regeneration of the FLR.…”
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    Impact of endothelial nitric oxide synthase activation on accelerated liver regeneration in a rat ALPPS model
  20. 31920
    “…Objective: Due to the pivotal role of miRNAs in AHD, we analyzed the differentially expressed miRNAs (DEmiRs) in RSV-infected patients, asthma patients, and COPD patients from public datasets and explored the mechanisms of association between RSV and AHD. …”
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    miR-34b/c-5p/CXCL10 Axis Induced by RSV Infection Mediates a Mechanism of Airway Hyperresponsive Diseases
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