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  1. 31981
    “…The molecular research conducted here also plays a pivotal role in drug discovery and vaccine development. …”
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    Chromosome-scale genome of the human blood fluke Schistosoma mekongi and its implications for public health
  2. 31982
    “…CD4 and cTfh cells may serve as pivotal markers of enduring and protective antibody levels. …”
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    A third (booster) dose of the inactivated SARS-CoV-2 vaccine elicits immunogenicity and T follicular helper cell responses in people living with HIV
  3. 31983
    “…This study identified the pivotal sepsis-associated hub gene STAT3 and demonstrated that exosomes derived from BMSCs can target STAT3, thereby inhibiting macrophage pyroptosis. …”
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    Mitigation of Sepsis-Induced Acute Lung Injury by BMSC-Derived Exosomal miR-125b-5p Through STAT3-Mediated Suppression of Macrophage Pyroptosis
  4. 31984
    por Schuetz, Georg M, Schlattmann, Peter, Achenbach, Stephan, Budoff, Matthew, Garcia, Mario J, Roehle, Robert, Pontone, Gianluca, Meijboom, Willem Bob, Andreini, Daniele, Alkadhi, Hatem, Honoris, Lily, Bettencourt, Nuno, Hausleiter, Jörg, Leschka, Sebastian, Gerber, Bernhard L, Meijs, Matthijs FL, Shabestari, Abbas Arjmand, Sato, Akira, Zimmermann, Elke, Schoepf, Uwe J, Diederichsen, Axel, Halon, David A, Mendoza-Rodriguez, Vladimir, Hamdan, Ashraf, Nørgaard, Bjarne L, Brodoefel, Harald, Øvrehus, Kristian A, Jenkins, Shona MM, Halvorsen, Bjørn A, Rixe, Johannes, Sheikh, Mehraj, Langer, Christoph, Martuscelli, Eugenio, Romagnoli, Andrea, Scholte, Arthur JHA, Marcus, Roy P, Ulimoen, Geir R, Nieman, Koen, Mickley, Hans, Nikolaou, Konstantin, Tardif, Jean-Claude, Johnson, Thorsten RC, Muraglia, Simone, Chow, Benjamin JW, Maintz, David, Laule, Michael, Dewey, Marc
    Publicado 2013
    “…DISCUSSION: This collaborative individual patient data meta-analysis should provide answers to the pivotal question of which patients benefit most from noninvasive coronary computed tomography angiography and thus help to adequately select the right patients for this test.…”
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    Individual patient data meta-analysis for the clinical assessment of coronary computed tomography angiography: protocol of the Collaborative Meta-Analysis of Cardiac CT (CoMe-CCT)
  5. 31985
    “…Detailed understanding of the ontogenetic, cellular and molecular characteristics of functional intervertebral disc (IVD) cell populations is pivotal to the successful development of cell replacement therapies and IVD regeneration. …”
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    Novel immortal human cell lines reveal subpopulations in the nucleus pulposus
  6. 31986
    “…To date, several studies have demonstrated that the activation of the immune system undoubtedly plays a pivotal role in SSc pathogenesis. Activated immune effector T cells contribute to the release of various pro-inflammatory cytokines and drive the SSc-specific autoantibody responses. …”
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    Hypomethylation and overexpression of ITGAL (CD11a) in CD4(+) T cells in systemic sclerosis
  7. 31987
    “…Conclusion After adjustment for healthy candidate bias and confounding, the benefits of primary ICD therapy seen in pivotal trials were not apparent in patients aged 66 or over who received ICDs during a hospital admission for exacerbation of heart failure or other acute co-morbidities. …”
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    Real world effectiveness of primary implantable cardioverter defibrillators implanted during hospital admissions for exacerbation of heart failure or other acute co-morbidities: cohort study of older patients with heart failure
  8. 31988
    “…CONCLUSION: Copper and its pivotal role to sustain cellular functions is noteworthy. …”
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    The trade-off of availability and growth inhibition through copper for the production of copper-dependent enzymes by Pichia pastoris
  9. 31989
    “…Various studies have shown that activation of the immune system plays a pivotal role in the development of fatigue. However, the mechanisms underlying the association between immune activation and fatigue remained elusive, and few reports have described the involvement of NLRP3 inflammasome activation in fatigue. …”
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    Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome
  10. 31990
    “…BACKGROUND: Neuroinflammation in utero may contribute to brain injury resulting in life-long neurological disabilities. The pivotal role of the efferent cholinergic anti-inflammatory pathway (CAP) in controlling inflammation, e.g., by inhibiting the HMGB1 release, via the macrophages’ α7 nicotinic acetylcholine receptor (α7nAChR) has been described in adults, but its importance in the fetus is unknown. …”
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    Decreased neuroinflammation correlates to higher vagus nerve activity fluctuations in near-term ovine fetuses: a case for the afferent cholinergic anti-inflammatory pathway?
  11. 31991
    “…Xanthine oxidase is also recognized as a pivotal enzyme in the production of oxidative stress. …”
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    Rationale and design of a multicenter randomized study for evaluating vascular function under uric acid control using the xanthine oxidase inhibitor, febuxostat: the PRIZE study
  12. 31992
    “…BACKGROUND: High-mobility group protein box1 (HMGB1) is a pivotal factor in the development and progression of many types of tumor. …”
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    High-mobility group protein box1 expression correlates with peritumoral macrophage infiltration and unfavorable prognosis in patients with hepatocellular carcinoma and cirrhosis
  13. 31993
    “…Recent studies suggest that complement activation plays a pivotal role in GBS-associated axonal degeneration, and eculizumab is a humanized monoclonal antibody that specifically binds to complement component 5 and potently inhibits complement activation. …”
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    A Prospective, Multicenter, Randomized Phase II Study to Evaluate the Efficacy and Safety of Eculizumab in Patients with Guillain-Barré Syndrome (GBS): Protocol of Japanese Eculizumab Trial for GBS (JET-GBS)
  14. 31994
    “…BACKGROUND: Previous studies have indicated that inefficient energy utilization may play a pivotal role in hypertrophic cardiomyopathy (HCM). …”
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    Sex-related differences in the associations between plasma free fatty acid levels and clinical features in patients with hypertrophic cardiomyopathy
  15. 31995
    “…CONCLUSIONS: In summary, Foxn1 appears to be a pivotal control element of the developmental program and skin maturation. …”
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    Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing
  16. 31996
    “…We sought to characterize the molecular response to canakinumab and evaluate potential markers of response using samples from two pivotal trials in systemic juvenile idiopathic arthritis (SJIA). …”
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    Early changes in gene expression and inflammatory proteins in systemic juvenile idiopathic arthritis patients on canakinumab therapy
  17. 31997
    “…BACKGROUND: Vascular dysfunction is a pivotal event in the development of diabetes-associated vascular disease. …”
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    The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction
  18. 31998
    “…Dentists and health workers should do more because they have a pivotal role in early diagnosis by performing oral cancer screening, raising levels of knowledge and in rectifying misconceptions about oral cancer. …”
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    Oral Cancer Awareness Among Dental Patients in Omdurman, Sudan: a cross-sectional Study
  19. 31999
    “…Increasing knowledge of the heterogeneity of the luminal A subtype may add pivotal information to guide therapeutic choices, evidently bringing us closer to improved treatment for this largest subgroup of breast cancer. …”
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    Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome
  20. 32000
    “…BACKGROUND: The spleen plays a pivotal role in the rapid clearance of parasitized red blood cells in patients with falciparum malaria after artemisinin treatment. …”
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    Prolonged parasite clearance in a Chinese splenectomized patient with falciparum malaria imported from Nigeria
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