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32001por Zhao, Weilin, Ma, Ning, Wang, Shumin, Mo, Yingxi, Zhang, Zhe, Huang, Guangwu, Midorikawa, Kaoru, Hiraku, Yusuke, Oikawa, Shinji, Murata, Mariko, Takeuchi, Kazuhiko“…Recent studies in epigenetics suggest that DNA methylation plays a pivotal role in the onset and progression of cancer. …”
Publicado 2017
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32002por Alexander, Joe, Edwards, Roger A., Savoldelli, Alberto, Manca, Luigi, Grugni, Roberto, Emir, Birol, Whalen, Ed, Watt, Stephen, Brodsky, Marina, Parsons, Bruce“…METHODS: We utilized three pivotal RCTs of pregabalin (398 North American patients) and the largest observational study of pregabalin (3159 German patients). …”
Publicado 2017
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32003por Sinderewicz, Emilia, Grycmacher, Katarzyna, Boruszewska, Dorota, Kowalczyk-Zięba, Ilona, Staszkiewicz, Joanna, Ślężak, Tomasz, Woclawek-Potocka, Izabela“…Ovarian granulosa cells play a pivotal role in follicle growth and development. Nevertheless, the role of LPA in the local regulation of granulosa cell function in different follicle categories in the bovine ovary has not been investigated. …”
Publicado 2017
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32004por Jacobsen, Frode F., Mekki, Tone Elin, Førland, Oddvar, Folkestad, Bjarte, Kirkevold, Øyvind, Skår, Randi, Tveit, Eva Marie, Øye, Christine“…In this connection, the role of the nursing home leaders appeared to be a pivotal element promoting or hindering person-centered care. …”
Publicado 2017
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32005por Liu, Yanqing, Chen, Xiaorui, Cheng, Rongjie, Yang, Fei, Yu, Mengchao, Wang, Chen, Cui, Shufang, Hong, Yeting, Liang, Hongwei, Liu, Minghui, Zhao, Chihao, Ding, Meng, Sun, Wu, Liu, Zhijian, Sun, Feng, Zhang, Chenyu, Zhou, Zhen, Jiang, Xiaohong, Chen, Xi“…Hu antigen R (HuR), which is highly upregulated in CRC, functions as a pivotal oncogene to promote CRC progression. However, the underlying cause of its dysregulation is poorly understood. …”
Publicado 2018
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32006por Liu, Lulu, Wan, Xiaoling, Zhou, Peipei, Zhou, Xiaoyuan, Zhang, Wei, Hui, Xinhui, Yuan, Xiujie, Ding, Xiaodan, Zhu, Ruihong, Meng, Guangxun, Xiao, Hui, Ma, Feng, Huang, He, Song, Xianmin, Zhou, Bin, Xiong, Sidong, Zhang, Yan“…Baf200, a subunit of PBAF complex, plays a pivotal role in heart morphogenesis and coronary artery angiogenesis. …”
Publicado 2018
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32007por Chen, Nan, Qian, Jiaqi, Chen, Jianghua, Yu, Xueqing, Mei, Changlin, Hao, Chuanming, Jiang, Gengru, Lin, Hongli, Zhang, Xinzhou, Zuo, Li, He, Qiang, Fu, Ping, Li, Xuemei, Ni, Dalvin, Hemmerich, Stefan, Liu, Cameron, Szczech, Lynda, Besarab, Anatole, Neff, Thomas B., Peony Yu, Kin-Hung, Valone, Frank H.“…It is currently being investigated in a pivotal global Phase 3 program.…”
Publicado 2017
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32008por Desert, C., Baéza, E., Aite, M., Boutin, M., Le Cam, A., Montfort, J., Houee-Bigot, M., Blum, Y., Roux, P. F., Hennequet-Antier, C., Berri, C., Metayer-Coustard, S., Collin, A., Allais, S., Le Bihan, E., Causeur, D., Gondret, F., Duclos, M. J., Lagarrigue, S.“…This result suggests a pivotal role for SREBF1 in lipogenesis regulation in response to a decrease in dietary starch and an increase in dietary PUFA. …”
Publicado 2018
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32009por Matsushita, Junya, Okamura, Kazuyuki, Nakabayashi, Kazuhiko, Suzuki, Takehiro, Horibe, Yu, Kawai, Tomoko, Sakurai, Toshihiro, Yamashita, Satoshi, Higami, Yoshikazu, Ichihara, Gaku, Hata, Kenichiro, Nohara, Keiko“…Epigenetic modifications, including DNA methylation, are among pivotal control mechanisms of gene expression leading to carcinogenesis. …”
Publicado 2018
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32010por Steijlen, Annemarijn SM, Jansen, Kaspar MB, Albayrak, Armagan, Verschure, Derk O, Van Wijk, Diederik F“…Early diagnosis is of pivotal importance for patients with cardiac arrhythmias and ischemia to minimize the consequences like strokes and myocardial infarctions. …”
Publicado 2018
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32011por Handschuh, Luiza, Wojciechowski, Pawel, Kazmierczak, Maciej, Marcinkowska-Swojak, Malgorzata, Luczak, Magdalena, Lewandowski, Krzysztof, Komarnicki, Mieczyslaw, Blazewicz, Jacek, Figlerowicz, Marek, Kozlowski, Piotr“…In acute myeloid leukemia (AML), the mutational status of the gene seems to play a pivotal role in carcinogenesis. Therefore, the aim of the study was to quantify alternative NPM1 transcripts in two types of acute leukemia, AML and ALL (acute lymphoblastic leukemia). …”
Publicado 2018
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32012por Di Cristofaro, Julie, Karlmark, Karlin R., Kanaan, Sami B., Azzouz, Doua F., El Haddad, Marina, Hubert, Lucas, Farge-Bancel, Dominique, Granel, Brigitte, Harlé, Jean Robert, Hachulla, Eric, Pardoux, Etienne, Roudier, Jean, Picard, Christophe, Lambert, Nathalie C.“…The non-classical class-I human leukocyte antigen (HLA) molecule HLA-G plays a pivotal role for the implantation and maintenance of pregnancy and has often been investigated in offspring from women with pregnancy complications. …”
Publicado 2018
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32013por Tang, Liyuan, Ma, Wei, Noor, Mehmood Ali, Li, Lianlu, Hou, Haipeng, Zhang, Xiangyun, Zhao, Ming“…Differential response of maize hybrids to high plant density greatly affect the dry matter accumulation and its allocation to maize kernel, depending upon various traits responsible for crowding stress tolerance, of which ear characteristics are pivotal. Density resistance as a quality appraisal of certain variety permits the construction of a simple and accurate method to determine this value, useful for plant breeding. …”
Publicado 2018
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32014por Hedrick, James, Christensen, Shane, Chang, Lee-Jah, Pan, Judy, Jordanov, Emilia, Dhinghra, Mandeep“…BACKGROUND: The MenACYW-TT conjugate vaccine is a quadrivalent meningococcal vaccine candidate intended for global use in all age groups. This pivotal phase II study evaluated the safety and immunogenicity of the vaccine when compared with a licensed quadrivalent conjugated meningococcal vaccine (MCV4-CRM) when co-administered with tetanus, diphtheria, acellular pertussis (Tdap), and human papilloma virus (HPV4) vaccines in meningococcal vaccine naïve adolescents (10–17 years of age). …”
Publicado 2018
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32015por Wang, Ruifen, Sun, Yeqi, Yu, Wenwei, Yan, Yu, Qiao, Meng, Jiang, Ruiqi, Guan, Wenbin, Wang, Lifeng“…BACKGROUND: Cancer-associated fibroblasts (CAFs), one of the principal constituents of the tumor microenvironment, have a pivotal role in tumor progression. Dysregulation of microRNAs (miRNAs) in CAFs contributes to the tumor-promoting ability of CAFs. …”
Publicado 2019
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32016por Kadowaki, Maiko, Yamada, Hidenori, Sato, Koichi, Shigemi, Hiroko, Umeda, Yukihiro, Morikawa, Miwa, Waseda, Yuko, Anzai, Masaki, Kamide, Yosuke, Aoki-Saito, Haruka, Hisada, Takeshi, Okajima, Fumikazu, Ishizuka, Tamotsu“…CONCLUSIONS: CXCL8 released from ASMCs by extracellular acidification may play a pivotal role in airway accumulation of neutrophils. …”
Publicado 2019
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32017por Bartolomaeus, Hendrik, Balogh, András, Yakoub, Mina, Homann, Susanne, Markó, Lajos, Höges, Sascha, Tsvetkov, Dmitry, Krannich, Alexander, Wundersitz, Sebastian, Avery, Ellen G., Haase, Nadine, Kräker, Kristin, Hering, Lydia, Maase, Martina, Kusche-Vihrog, Kristina, Grandoch, Maria, Fielitz, Jens, Kempa, Stefan, Gollasch, Maik, Zhumadilov, Zhaxybay, Kozhakhmetov, Samat, Kushugulova, Almagul, Eckardt, Kai-Uwe, Dechend, Ralf, Rump, Lars Christian, Forslund, Sofia K., Müller, Dominik N., Stegbauer, Johannes, Wilck, Nicola“…The gut microbiome plays a pivotal role in immune homeostasis and cardiovascular health. …”
Publicado 2019
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32018por Costantini, Daniele, Overi, Diletta, Casadei, Luca, Cardinale, Vincenzo, Nevi, Lorenzo, Carpino, Guido, Di Matteo, Sabina, Safarikia, Samira, Valerio, Mariacristina, Melandro, Fabio, Bizzarri, Mariano, Manetti, Cesare, Berloco, Pasquale Bartolomeo, Gaudio, Eugenio, Alvaro, Domenico“…Many pivotal biological cell processes are affected by gravity. …”
Publicado 2019
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32019por Wagner, Felix, Hölig, Ulrike, Wilczkowski, Friederike, Plesca, Ioana, Sommer, Ulrich, Wehner, Rebekka, Kießler, Maximilian, Jarosch, Armin, Flecke, Katharina, Arsova, Maia, Tunger, Antje, Bogner, Andreas, Reißfelder, Christoph, Weitz, Jürgen, Schäkel, Knut, Troost, Esther G. C., Krause, Mechthild, Folprecht, Gunnar, Bornhäuser, Martin, Bachmann, Michael P., Aust, Daniela, Baretton, Gustavo, Schmitz, Marc“…Neoadjuvant radiochemotherapy (nRCT) can significantly influence the tumor immune architecture that plays a pivotal role in regulating tumor growth. Whereas, various studies have investigated the effect of nRCT on tumor-infiltrating T cells, little is known about its impact on the frequency and activation status of human dendritic cells (DCs). …”
Publicado 2019
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32020por Guevara-Hoyer, Kissy, Gil, Celia, Parker, Antony R., Williams, Leigh J., Orte, Carmen, Rodriguez de la Peña, Antonia, Ochoa-Grullón, Juliana, Rodriguez De Frias, Edgard, García, Irene Serrano, García-Gómez, Sonia, Recio, M. José, Fernández-Arquero, Miguel, Pérez de Diego, Rebeca, Ramos, Jose Tomas, Sánchez-Ramón, Silvia“…Background: The assessment of specific polysaccharide antibody production plays a pivotal role in the diagnosis of humoral primary immunodeficiencies (PID). …”
Publicado 2019
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