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  1. 32061
    “…METHODS: In an ongoing multinational, placebo-controlled, observer-blinded, pivotal efficacy trial, we randomly assigned persons 16 years of age or older in a 1:1 ratio to receive two doses, 21 days apart, of either placebo or the BNT162b2 vaccine candidate (30 μg per dose). …”
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    Online Artículo Texto
    Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
  2. 32062
    “…PURPOSE: Accurate contouring of intraprostatic gross tumor volume (GTV) is pivotal for successful delivery of focal therapies and for biopsy guidance in patients with primary prostate cancer (PCa). …”
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    Comparison of Manual and Semi-Automatic [(18)F]PSMA-1007 PET Based Contouring Techniques for Intraprostatic Tumor Delineation in Patients With Primary Prostate Cancer and Validation With Histopathology as Standard of Reference
  3. 32063
    “…METHODS: The safety and immunogenicity of MenACYW-TT in subjects ≥ 2 years was evaluated in 5 pivotal randomized, active-controlled clinical trials. …”
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    1243. Semi-Quantitative Benefit-Risk Assessment for a New Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) in Individuals 2 Years of Age and Older
  4. 32064
    “…BACKGROUND: Accumulating evidence has demonstrated that long non-coding RNAs (lncRNAs) are involved in the hypoxia-related cancer process and play pivotal roles in enabling malignant cells to survive under hypoxic stress. …”
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    Hypoxia-sensitive long noncoding RNA CASC15 promotes lung tumorigenesis by regulating the SOX4/β-catenin axis
  5. 32065
    “…Subchondral bone stem/progenitor cells (SCB-SPCs), originating from the pivotal zone of the osteochondral unit, have been shown to have multipotency and self-renewal properties. …”
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    Radial extracorporeal shockwave promotes subchondral bone stem/progenitor cell self-renewal by activating YAP/TAZ and facilitates cartilage repair in vivo
  6. 32066
    “…BACKGROUND: Thermal plasticity is pivotal for evolution in changing climates and in mediating resilience to its potentially negative effects. …”
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    Online Artículo Texto
    DNA methyltransferase 3a mediates developmental thermal plasticity
  7. 32067
    “…BACKGROUND: Interleukin-33 (IL-33) plays a pivotal role in regulating innate immune response and metabolic homeostasis. …”
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    Online Artículo Texto
    Circulating levels of IL-33 are elevated by obesity and positively correlated with metabolic disorders in Chinese adults
  8. 32068
    “…CONCLUSION: Analysis of our findings, in accordance with the available published data, argues in favour of the notion that the activated E2F1 signalling pathway, which can be responsible for both inappropriate cell proliferation and initial chromosomal instability, plays a pivotal role in HCC development and progression. A dedifferentiation switch that manifests in exaggerated gene expression changes might be due to turning on transcriptional co-regulators with broad impact on gene expression, e.g. …”
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    Gene networks and transcriptional regulators associated with liver cancer development and progression
  9. 32069
    “…This mechanism could provide pivotal potential prognostic biomarkers and therapeutic targets for BCa.…”
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    circST6GALNAC6 suppresses bladder cancer metastasis by sponging miR-200a-3p to modulate the STMN1/EMT axis
  10. 32070
    “…INTRODUCTION: In patients with septic shock, low levels of circulating immunoglobulins are common and their kinetics appear to be related to clinical outcome. The pivotal role of immunoglobulins in the host immune response to infection suggests that additional therapy with polyclonal intravenous immunoglobulins may be a promising option in patients with septic shock. …”
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    Adjunctive IgM-enriched immunoglobulin therapy with a personalised dose based on serum IgM-titres versus standard dose in the treatment of septic shock: a randomised controlled trial (IgM-fat trial)
  11. 32071
    “…An indirect comparison of pivotal clinical trial data was performed to evaluate the relative efficacy of two extended half-life therapies approved for the prophylactic treatment of haemophilia A: recombinant FVIII–IgG(1) Fc domain fusion protein (rFVIIIFc) and pegylated rFVIII (BAY 94-9027). …”
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    Recombinant FVIIIFc Versus BAY 94-9027 for Treatment of Patients with Haemophilia A: Comparative Efficacy Using a Matching Adjusted Indirect Comparison
  12. 32072
    “…Previous studies revealed pivotal functions of WNT family members in colorectal cancer, as well as their prognostic values. …”
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    Activation of WNT7b autocrine eases metastasis of colorectal cancer via epithelial to mesenchymal transition and predicts poor prognosis
  13. 32073
    “…This protein plays a pivotal role in T cell antigen receptor (TCR) signaling, so triggering the activation of various pathways. …”
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    Plant microRNAs from Moringa oleifera Regulate Immune Response and HIV Infection
  14. 32074
    por Pham, David N.
    Publicado 2021
    “…Benralizumab treatment causes near-complete depletion of circulating eosinophils and was approved in 2017 for add-on, maintenance treatment of severe asthma with an eosinophilic phenotype, based on the results of the CALIMA and SIROCCO pivotal trials. Benralizumab is not currently approved for the treatment of eosinophilic conditions besides asthma; however, during the CALIMA trial, spontaneous resolution of atopic dermatitis was observed in a patient, concurrent with reduction in her asthma symptoms. …”
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    Spontaneous resolution of atopic dermatitis incidental to participation in benralizumab clinical trial for severe, uncontrolled asthma: a case report
  15. 32075
    “…CONCLUSIONS: Elevated SII represents an independent negative prognostic factor above all others for both OS and PFS in advanced PDAC patients treated with first-line chemotherapy, thus confirming a pivotal role of systemic inflammation on PDAC progression and on patient outcome.…”
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    Systemic immune-inflammation index: a prognostic tiebreaker among all in advanced pancreatic cancer
  16. 32076
    “…While there was a meaningful improvement in visual acuity for REVEAL subjects, the final visual acuity was less favorable than that seen in the two subsequent pivotal phase III studies in which subjects were treated earlier during the course of their disease. …”
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    Safety of Intravitreal Gene Therapy for Treatment of Subjects with Leber Hereditary Optic Neuropathy due to Mutations in the Mitochondrial ND4 Gene: The REVEAL Study
  17. 32077
    “…Personal Recollections Organized as Data (PROD) is a novel methodology for understanding patients’ health experiences in order to improve care. PROD pivots qualitative data collection and analysis around the validated domains and dimensions measured in patient-reported outcome and patient-reported experience questionnaires. …”
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    Personal Accounts of Young-Onset Colorectal Cancer Organized as Patient-Reported Data: Protocol for a Mixed Methods Study
  18. 32078
    “…BACKGROUND: Molecular imaging with molecularly targeted probes is a powerful tool for studying the spatio-temporal interactions between complex biological processes. The pivotal role of the receptor for advanced glycation end products (RAGE), and its involvement in numerous pathological processes, aroused the demand for RAGE-targeted imaging in various diseases. …”
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    Molecularly targeted nanoparticles: an emerging tool for evaluation of expression of the receptor for advanced glycation end products in a murine model of peripheral artery disease
  19. 32079
    por Villarreal, Alcibiades, Rangel, Giselle, Zhang, Xu, Wong, Digna, Britton, Gabrielle, Fernandez, Patricia L., Pérez, Ambar, Oviedo, Diana, Restrepo, Carlos, Carreirra, María B., Sambrano, Dilcia, Eskildsen, Gilberto A., De La Guardia, Carolina, Flores-Cuadra, Julio, Carrera, Jean-Paul, Zaldivar, Yamitzel, Franco, Danilo, López-Vergès, Sandra, Zhang, Dexi, Fan, Fangjing, Wang, Baojun, Sáez-Llorens, Xavier, DeAntonio, Rodrigo, Torres-Atencio, Ivonne, Blanco, Isabel, Subía, Fernando Diaz, Mudarra, Laiss, Benzadon, Aron, Valverde, Walter, López, Lineth, Hurtado, Nicolás, Rivas, Neyla, Jurado, Julio, Carvallo, Aixa, Rodriguez, Juan, Perez, Yaseikiry, Morris, Johanna, Luque, Odemaris, Cortez, David, Ortega-Barria, Eduardo, Kosagisharaf, Rao, Lleonart, Ricardo, Li, Chong, Goodridge, Amador
    Publicado 2021
    “…The serological detection of antibodies against the virus will play a pivotal role in complementing molecular tests to improve diagnostic accuracy, contact tracing, vaccine efficacy testing, and seroprevalence surveillance. …”
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    Performance of a Point of Care Test for Detecting IgM and IgG Antibodies Against SARS-CoV-2 and Seroprevalence in Blood Donors and Health Care Workers in Panama
  20. 32080
    “…Refugee children’s psychosocial needs and wellbeing are often overlooked, and post-migration support is of pivotal importance. METHODS: An easy accessible movement–based psychosocial intervention, called TeamUp, was developed for children aged 6–17 living in refugee reception centres. …”
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    Process evaluation of TeamUp: a movement-based psychosocial intervention for refugee children in the Netherlands
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