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  1. 32141
    “…All CFTR modulators have been licensed in the US as orphan drugs, but in the EU the orphan status for LUM/IVA was not confirmed at the time of marketing authorization as results from the pivotal trial were not considered clinically significant. …”
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    The impact of FDA and EMA regulatory decision-making process on the access to CFTR modulators for the treatment of cystic fibrosis
  2. 32142
    “…CONCLUSION: This exploratory study highlights the potential of (68)Ga-NOTA-anti-MMR Nb to image MR-positive macrophages that are known to play a pivotal role in wound healing that follows acute MI.…”
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    In vivo Visualization of M2 Macrophages in the Myocardium After Myocardial Infarction (MI) Using (68)Ga-NOTA-Anti-MMR Nb: Targeting Mannose Receptor (MR, CD206) on M2 Macrophages
  3. 32143
    “…BACKGROUND: Tumor microenvironment plays pivotal roles in carcinogenesis, cancer development and metastasis. …”
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    Online Artículo Texto
    Association of the tissue infiltrated and peripheral blood immune cell subsets with response to radiotherapy for rectal cancer
  4. 32144
    “…BACKGROUND: Erenumab is a monoclonal antibody (mAb) against the calcitonin gene related peptide (CGRP) receptor and is commonly used in migraine prophylaxis. Pivotal and open-label studies show a good safety and tolerability. …”
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    Online Artículo Texto
    Twelve-month safety, tolerability and susceptibility to adverse events of prophylactic migraine therapy with erenumab: a retrospective real-world study
  5. 32145
    “…BACKGROUND: The LH surge is a pivotal event that triggers multiple key ovarian processes including oocyte maturation, cumulus expansion, follicular wall rupture and luteinization of mural granulosa and theca cells. …”
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    Online Artículo Texto
    The granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin
  6. 32146
    “…CONCLUSIONS: The pre-treatment CD163(+)macrophages infiltration would be a pivotal biomarker for predicting prognosis and pathological response to multidisciplinary treatment among TIICs in MGC. …”
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    Online Artículo Texto
    Prognostic value of tumor-infiltrating CD163(+)macrophage in patients with metastatic gastric cancer undergoing multidisciplinary treatment
  7. 32147
    “…The implementation of a sustainable, structured and long-term IMS management programme, integrating active and passive entomological surveillance, vector control and Public Health surveillance is therefore pivotal. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13071-022-05303-w.…”
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    From a long-distance threat to the invasion front: a review of the invasive Aedes mosquito species in Belgium between 2007 and 2020
  8. 32148
    “…Cis-acting elements for their responses to light, drought, temperature (heat and cold), and hormone distributed widely in the promoters of SoBSKs, implying the pivotal roles of SoBSKs in response to diverse abiotic stresses and phytohormone stimuli. …”
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    Genome-wide identification and expression analysis reveals spinach brassinosteroid-signaling kinase (BSK) gene family functions in temperature stress response
  9. 32149
    “…The miRNAs have been found to play pivotal roles in the several regulatory functions influencing the prognosis of viral infection. …”
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    MicroRNAs in the development of potential therapeutic targets against COVID-19: A narrative review
  10. 32150
    “…BACKGROUND: Vector control is still a pivotal method for preventing malaria, and its potency is weakened by the increasing resistance of vectors to chemical insecticides. …”
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    Population genetic structure and evolutionary genetics of Anopheles sinensis based on knockdown resistance (kdr) mutations and mtDNA-COII gene in China–Laos, Thailand–Laos, and Cambodia–Laos borders
  11. 32151
    “…Ample evidence has established a pivotal role for significantly reduced mitophagy in the ageing heart. …”
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    LncRNA LOC105378097 inhibits cardiac mitophagy in natural ageing mice
  12. 32152
    “…Despite the wide acknowledgment of the pivotal role of the stromal compartment in the fibrotic response to PO, the possible effects of DDR-persistent activation in cardiac stromal cell (C-MSC) are still unknown. …”
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    Pressure Overload Activates DNA-Damage Response in Cardiac Stromal Cells: A Novel Mechanism Behind Heart Failure With Preserved Ejection Fraction?
  13. 32153
    “…Hence, training this pivotal examination can be supported by a custom designed anatomical model tailored for interactive and explorative learning.…”
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    Evaluating the value of a 3D printed model for hands-on training of gynecological pelvic examination
  14. 32154
    “…Lenadogene nolparvovec was administered by intravitreal injection (IVT) in LHON patients harboring the m.11778G > A ND4 mutation in a clinical development program including one phase 1/2 study (REVEAL), three phase 3 pivotal studies (REVERSE, RESCUE, REFLECT), and one long-term follow-up study (RESTORE, the follow-up of REVERSE and RESCUE patients). …”
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    Absence of lenadogene nolparvovec DNA in a brain tumor biopsy from a patient in the REVERSE clinical study, a case report
  15. 32155
    “…CONCLUSIONS: Our data demonstrated that inflammatory Th17 cells were pivotal in accelerating the onset and exacerbation of depressive symptoms in CRS-exposed rats. …”
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    Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain
  16. 32156
    “…In patients with decEPH, the preoperative assessment of the “true AOS” under PAT reflects a pivotal requirement for successful strabismus surgery, as 82% had dose relevant angle changes ≥ 3 pdpt. …”
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    Prism adaptation test before strabismus surgery in patients with decompensated esophoria and decompensated microesotropia
  17. 32157
    “…The cerebellum and periaqueductal gray (PAG) play pivotal roles in the neural circuits of pain conduction and analgesia in migraine. …”
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    Gamma-aminobutyric acid and glutamate/glutamine levels in the dentate nucleus and periaqueductal gray with episodic and chronic migraine: a proton magnetic resonance spectroscopy study
  18. 32158
    “…These findings suggest that intestinal bacterial leakage plays a pivotal role in SpA pathogenesis.…”
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    Oral dextran sulfate sodium administration induces peripheral spondyloarthritis features in SKG mice accompanied by intestinal bacterial translocation and systemic Th1 and Th17 cell activation
  19. 32159
    por Liu, Xiaoxue, Wang, Fang, Yu, Chuanhua, Zhou, Maigeng, Yu, Yong, Qi, Jinlei, Yin, Peng, Yu, Shicheng, Zhou, Yuchang, Lin, Lin, Liu, Yunning, Wang, Qiqi, Zhong, Wenling, Huang, Shaofen, Li, Yanxia, Liu, Li, Liu, Yuan, Ma, Fang, Zhang, Yine, Tian, Yuan, Yu, Qiuli, Zeng, Jing, Pan, Jingju, Zhou, Mengge, Kang, Weiwei, Zhou, Jin-Yi, Yu, Hao, Liu, Yuehua, Li, Shaofang, Yu, Huiting, Wang, Chunfang, Xia, Tian, Xi, Jinen, Ren, Xiaolan, Xing, Xiuya, Cheng, Qianyao, Fei, Fangrong, Wang, Dezheng, Zhang, Shuang, He, Yuling, Wen, Haoyu, Liu, Yan, Shi, Fang, Wang, Yafeng, Sun, Panglin, Bai, Jianjun, Wang, Xuyan, Shen, Hui, Ma, Yudiyang, Yang, Donghui, Mubarik, Sumaira, Cao, Jinhong, Meng, Runtang, Zhang, Yunquan, Guo, Yan, Yan, Yaqiong, Zhang, Wei, Ke, Sisi, Zhang, Runhua, Wang, Dingyi, Zhang, Tingting, Nomura, Shuhei, Hay, Simon I., Salomon, Joshua A., Haagsma, Juanita A., Murray, Christopher J.L., Vos, Theo
    Publicado 2022
    “…BACKGROUND: The disability weight (DW) quantifies the severity of health states from disease sequela and is a pivotal parameter for disease burden calculation. …”
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    Eliciting national and subnational sets of disability weights in mainland China: Findings from the Chinese disability weight measurement study
  20. 32160
    “…Thus, there is a strong rational to combine an anti-cancer hTERT vaccine and an immune checkpoint inhibitor to activate and promote antitumor T-cell immunity. This pivotal proof of concept study will evaluate the efficacy and safety of the combination of a telomerase-based T(H)1 inducing vaccine (UCPVax) and an anti–PD-L1 (atezolizumab) immunotherapy in HPV(+) cancers, as well as confirming their synergic mechanism, and settling the basis for a new combination for future clinical trials. …”
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    A Phase II Study Evaluating the Interest to Combine UCPVax, a Telomerase CD4 T(H)1-Inducer Cancer Vaccine, and Atezolizumab for the Treatment of HPV Positive Cancers: VolATIL Study
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