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  1. 32201
    “…Together, our data suggest that cofilin inhibition provides a neuroprotective effect in in vitro and in vivo TBI mice models by inhibiting oxidative stress and inflammatory responses, the pivotal mechanisms involved in TBI-induced brain damage.…”
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    Cofilin Inhibitor Protects against Traumatic Brain Injury-Induced Oxidative Stress and Neuroinflammation
  2. 32202
    “…KEY MESSAGE: Our study used RNA sequencing (RNA-seq) to identify pivotal factors in coding and non-coding transcripts which differentiate between patients at risk for recurrent anal cancer after treatment. …”
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    RNA-seq analysis identifies transcriptomic profiles associated with anal cancer recurrence among people living with HIV
  3. 32203
    “…BACKGROUND: Cancer-associated fibroblasts (CAFs) play a pivotal role in cancer progression and are known to mediate endocrine and chemotherapy resistance through paracrine signaling. …”
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    Identification of prognostic cancer-associated fibroblast markers in luminal breast cancer using weighted gene co-expression network analysis
  4. 32204
    “…BACKGROUND: Ginsenoside Rh2 (G‐Rh2) exerts anti‐tumor activity in non‐small cell lung cancer (NSCLC). microRNAs (miRNAs, miRs) play pivotal roles in NSCLC. We aimed to investigate whether G‐Rh2 inhibited NSCLC progression by targeting miRNA. …”
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    Ginsenoside Rh2 attenuates the progression of non‐small cell lung cancer by sponging miR‐28‐5p/STK4 axis and inactivating Wnt/β‐catenin signaling
  5. 32205
    “…Changes in BMI, blood pressure, cholesterol level, experience of acute and chronic obesity-related complications, costs, and quality-adjusted life years (QALYs) were simulated over 30 years based on pivotal trials of the AOMs and other relevant literature. …”
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    Cost-effectiveness analysis of semaglutide 2.4 mg for the treatment of adult patients with overweight and obesity in the United States
  6. 32206
    “…In May 2019, regulatory approval of tafamidis provided the first pharmacologic treatment of ATTR-CM. In the pivotal phase 3 Transthyretin Amyloidosis Cardiomyopathy Clinical Trial (ATTR-ACT), 97.2% of patients were classified as adherent (defined as taking ≥ 80% of scheduled doses). …”
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    Baseline characteristics and secondary medication adherence among Medicare patients diagnosed with transthyretin amyloid cardiomyopathy and/or receiving tafamidis prescriptions: A retrospective analysis of a Medicare cohort
  7. 32207
    “…The safety profile in the second-line setting was consistent with the results shown in pivotal studies. PFS rates of patients were similar, regardless of TKI type. …”
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    Beyond atezolizumab plus bevacizumab in patients with advanced hepatocellular carcinoma: overall efficacy and safety of tyrosine kinase inhibitors in a real-world setting
  8. 32208
    “…The early identification and use of antiviral treatment with nucleos(t)ide analogues is a pivotal strategy to promote hepatic recompensation, which has the potential to significantly reduce mortality rates in patients with chronic HBV infection and ultimately aid in the elimination of hepatitis.…”
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    Baveno VII criteria for recompensation predict transplant-free survival in patients with hepatitis B-related decompensated cirrhosis
  9. 32209
    “…CONCLUSION: The movement of the trunk plays a pivotal role in determining the propulsion speed of wheelchair racing T54 athletes. …”
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    The effects of trunk kinematics and EMG activity of wheelchair racing T54 athletes on wheelchair propulsion speeds
  10. 32210
    “…OBJECTIVES: To (1) assess the prevalence and distribution of on-label telithromycin utilization before and after the revisions of the product label and (2) assess the association of pivotal events in the life cycle of telithromycin with its use as reflected in pharmacy and medical claims. …”
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    Telithromycin: The Perils of Hasty Adoption and Persistence of Off-Label Prescribing
  11. 32211
    “…Cervical sagittal balance plays a pivotal role in spine surgeries as it has a significant impact on the clinical outcomes in cervical spine surgery. …”
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    Effect of T1 Slope on Disappearance of Cervical Lordosis after Posterior Cervical Double-Door Laminoplasty Based on Medical Informatics
  12. 32212
    “…ABSTRACT: Glioma grading plays a pivotal role in guiding treatment decisions, predicting patient outcomes, facilitating clinical trial participation and research, and tailoring treatment strategies. …”
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    GradWise: A Novel Application of a Rank-Based Weighted Hybrid Filter and Embedded Feature Selection Method for Glioma Grading with Clinical and Molecular Characteristics
  13. 32213
    “…Heating drinking water during cold seasons plays a pivotal role in modulating internal energy processes. …”
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    Effects of Heated Drinking Water during the Cold Season on Serum Biochemistry, Ruminal Fermentation, Bacterial Community, and Metabolome of Beef Cattle
  14. 32214
    “…Consequently, targeting the GR signaling pathway might be pivotal and should be investigated in clinical studies.…”
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    Discovery of a glucocorticoid receptor (GR) activity signature correlates with immune cell infiltration in adrenocortical carcinoma
  15. 32215
    “…Aggressive wound care and analgesia are pivotal to treatment, in addition to addressing underlying precipitating conditions. …”
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    SAT214 A Rare Case Of Biopsy-proven Non-uremic Calciphylaxis In A Patient With Secondary Hyperparathyroidism
  16. 32216
    “…Black DM, Delmas PD, et al. HORIZON Pivotal Fracture Trial. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. …”
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    THU444 A Case Of Zoledronic-Acid Induced Acute Anterior Uveitis, Episcleritis, And Synovitis
  17. 32217
    “…This is especially important because pulsatile LH is pivotal to reproductive health in males and females. …”
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    SAT606 Comparison Of Psychosocial And Immune/Inflammatory Stress On Luteinizing Hormone Pulsatile Secretion
  18. 32218
    “…Conventional serological markers play a pivotal role in diagnosing and prognosticating CHB, but atypical serological profiles deviating from established norms pose challenges. …”
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    Unraveling the Complexity of Atypical Serological Profiles in Chronic Hepatitis B: Insights Into Disease Dynamics and Clinical Implications
  19. 32219
    “…INTRODUCTION: The neurotrophin system plays a pivotal role in the development, morphology, and survival of the nervous system, and its dysregulation has been manifested in numerous neurodegenerative and neuroinflammatory diseases. …”
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    A quest for the stereo-electronic requirements for selective agonism for the neurotrophin receptors TrkA and TrkB in 17-spirocyclic-dehydroepiandrosterone derivatives
  20. 32220
    “…The study underscores the pivotal importance of adhering rigorously to established protocols and guidelines for antibiotic prophylaxis. …”
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    Antibiotic Utilization and Prophylaxis in Paediatric Cardiac Surgery: A Retrospective Observational Study at a Rural Tertiary Care Hospital in India
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