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  1. 32321
    “…BACKGROUND AND OBJECTIVES: The information technology is a pivotal source of communication between patients and healthcare providers for managing chronic diseases. …”
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    Capacity and willingness to use information technology for managing chronic diseases among patients: A cross-sectional study in Lahore, Pakistan
  2. 32322
    “…BACKGROUND: We have shown that phospholipase Cε (PLCε), an effector of Ras and Rap1 small GTPases, plays pivotal roles in inflammation and inflammation-associated carcinogenesis by augmenting proinflammatory cytokine production from epithelial cells of various organs. …”
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    Phospholipase Cε plays a crucial role in neutrophilic inflammation accompanying acute lung injury through augmentation of CXC chemokine production from alveolar epithelial cells
  3. 32323
    “…Previous studies indicated that SOX2, the key transcription factor in gastric differentiation, was downregulated during IM development while CDX2, the pivotal intestine-specific transcription factor was upregulated significantly. …”
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    SOX2 interferes with the function of CDX2 in bile acid-induced gastric intestinal metaplasia
  4. 32324
    “…By co-IP, we found that the N-terminal domain (aa 32–128) of Plin5 was pivotal for its binding with NS5A. CONCLUSIONS: Our data highlight a protective role of Plin5 against hepatic lipotoxic injuries induced by HCV NS5A, which is helpful for understanding the steatosis and injuries in liver during HCV infection.…”
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    Perilipin 5 alleviates HCV NS5A-induced lipotoxic injuries in liver
  5. 32325
    “…Therefore, our findings further highlight the pivotal predictive role of IFG for HTN development as opposed to the limited independent role of abnormal HbA1c levels. …”
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    The association between fasting plasma glucose and glycated hemoglobin in the prediabetes range and future development of hypertension
  6. 32326
    “…Thus, to effectively obtain the evolved synthetic promoter exhibiting higher strength, it is essential to develop novel strategies to construct mutant library targeting the pivotal region rather than the arbitrary region of the template promoter. …”
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    Development of a novel strategy for robust synthetic bacterial promoters based on a stepwise evolution targeting the spacer region of the core promoter in Bacillus subtilis
  7. 32327
    “…IMPORTANCE: Universal early screening for autism spectrum disorder (ASD) in primary care is becoming increasingly common and is believed to be a pivotal step toward early treatment. However, the diagnostic stability of ASD in large cohorts from the general population, particularly in those younger than 18 months, is unknown. …”
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    Evaluation of the Diagnostic Stability of the Early Autism Spectrum Disorder Phenotype in the General Population Starting at 12 Months
  8. 32328
    por Bello Segura, Manuel, Subauste, Jose
    Publicado 2019
    “…Physiological regulation and disorders of phosphate metabolism--pivotal role of fibroblast growth factor 23. Intern Med. 2008;47(5):337-43. …”
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    MON-502 It's Not Always Osteoporosis: FGF-23 Induced Osteomalacia
  9. 32329
    “…The calcium-sensing receptor (CaSR) is a homodimeric G-protein coupled receptor that plays a pivotal role in extracellular Ca(2+) (Ca(2+)(e)) homeostasis, and loss- and gain-of-function mutations of the CaSR cause familial hypocalciuric hypercalcemia type 1 (FHH1) and autosomal dominant hypocalcemia type 1 (ADH1), respectively. …”
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    SAT-036 Extracellular Domain Calcium-Sensing Receptor (CaSR) Mutations Leading to Hypercalcemic and Hypocalcemic Disorders Cluster at the Homodimeric Interface
  10. 32330
    “…The pathogenesis is incompletely understood, but the development of cellular stress, including endoplasmic reticulum (ER) stress, might play a pivotal role (1). Indeed, markers of ER stress have been observed in critical illness, both in animal models and human patients, correlating with organ dysfunction (1). …”
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    SAT-155 Temporal Activation of the Unfolded Protein Response and Concomitant Downregulation of Key Hepatic Transcription Factors in Critical Illness
  11. 32331
    “…[Introduction] Primary hyperparathyroidism (PHPT) occasionally presents a hyperparathyroid crisis which provides a pivotal cue for its diagnosis. However, the perioperative risk for exacerbation of hypercalcemia has been unknown in PHPT. …”
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    SUN-496 A Perioperative Risk For Exacerbation of Hypercalcemia in Primary Hyperparathyroidism
  12. 32332
    “…An integration of the small RNA profiling data presented here and previous transcriptomic information suggests that sRNA-mediated regulation of auxin pathways is pivotal in promoting apomixis. These results will underlie future functional characterization of the molecular components mediating the switch from sexuality to apomixis. …”
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    Small RNA-seq reveals novel regulatory components for apomixis in Paspalum notatum
  13. 32333
    “…Overexpression of APE1, a pivotal enzyme of the BER pathway, as well as the expression of NPM1, a functional regulator of APE1, are associated with poor outcome and resistance to Pt-based therapies. …”
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    APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC
  14. 32334
    “…Information and communications technology (ICT), particularly robotics and domotics, could play a pivotal role in aging, especially in contemporary society, where relatives are not always able to accurately and constantly assist the older person. …”
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    How Prefrail Older People Living Alone Perceive Information and Communications Technology and What They Would Ask a Robot for: Qualitative Study
  15. 32335
    “…These findings highlight the shared prenatal impacts among allergic diseases, and studies are warranted to address the pivotal pathway in allergic diseases.…”
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    Shared prenatal impacts among childhood asthma, allergic rhinitis and atopic dermatitis: a population-based study
  16. 32336
    “…Subcutaneous C1-inhibitor (C1-INH [SC], HAEGARDA(®), CSL Behring) at the FDA-approved dose of 60 IU/kg is indicated as routine prophylaxis to prevent attacks in patients with HAE. In the pivotal phase III COMPACT trial, the median reduction in attack rate relative to placebo was 95% with twice-weekly C1-INH (SC) 60 IU/kg, and the median reduction in on-demand medication use was >99%. …”
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    Patterns of on-demand medication use in patients with hereditary angioedema treated long-term with prophylactic subcutaneous C1-inhibitor
  17. 32337
    “…RESULTS: The theoretically informed analysis pivots around the following factors connected to transparency: effectiveness; trust; accountability; autonomy and control; confidentiality, privacy, and anonymity; fairness; and legitimacy. …”
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    A Theoretical Twist on the Transparency of Open Notes: Qualitative Analysis of Health Care Professionals’ Free-Text Answers
  18. 32338
    “…Collectively, these novel findings suggest that CLCN3 may be a novel direct target of miR-205-5p and this CLCN3/miR-205-5p interaction may serve a pivotal role in regulating breast cancer cellular proliferation under physiological conditions.…”
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    MicroRNA-205-5p inhibits three-dimensional spheroid proliferation of ErbB2-overexpressing breast epithelial cells through direct targeting of CLCN3
  19. 32339
    “…Infection led to detectable TSST-1 in soft tissues, and TSST-1 was detected in draining lymph nodes, events which may be pivotal to TSS pathogenesis. The reduction in TSST-1 production and lesion size after a single dose of clindamycin underscores a potential role for adjunctive clindamycin at the start of treatment of patients suspected of having TSS to alter disease progression. …”
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    Toxic Shock Syndrome Toxin 1 Evaluation and Antibiotic Impact in a Transgenic Model of Staphylococcal Soft Tissue Infection
  20. 32340
    por Ying, Jian, Redd, Andrew, Greene, Tom
    Publicado 2018
    “…OBJECTIVES/SPECIFIC AIMS: The objective of this research is to determine under what conditions endpoints based on estimated glomerular filtration rate (eGFR) slope or on relatively small declines in eGFR provide valid and useful surrogate endpoints for pivotal clinical trials in chronic kidney disease (CKD) patients. …”
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    2091: Evaluating the validity and utility of surrogate endpoints in clinical trials of chronic kidney disease (CKD)
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