“…As a consequence of the positive results, AstraZeneca was engaged with the Medical Research Council trials unit to discuss regulatory submission using ICON6 as the single pivotal trial. METHODS: A relatively limited level of on-site monitoring, single data entry and investigator’s local evaluation of progression were used on trial. …”
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“…Operational NH characteristics – which might reflect a general nutritional awareness of the NH – seem to be pivotal for provision of TMD, whereas neither structural nor resident-related characteristics seem to play a role in this regard.…”
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“…In the future, integrated informatics derived from multimodality monitoring will play a pivotal role in clinical decision algorithms.…”
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“…Here, we examined the pivotal relationship between the mucosal microbiome and vaccine-induced immune responses by assessing longitudinal changes in vaginal and rectal microbiome profiles after intradermal immunization with a human immunodeficiency virus type 1 (HIV-1) DNA vaccine in adult rhesus macaques that received two prior DNA primes. …”
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“…Understanding the relationship between socio-demographic, sexual risk behavior, and psychosocial factors with PrEP awareness, willingness to use, and history of use among this group is pivotal to maximizing PrEP uptake. METHODS: Between March and June 2019, 419 participants completed an interviewer-administered survey assessing PrEP awareness, willingness to use, and history of use; socio-demographics; sexual risk behavior; and psychosocial factors. …”
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“…This research highlights that dietary energy content plays a pivotal role in modulating the relationship between MUC and dietary CP concentration in dairy sheep.…”
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“…Thus, the decision regarding delivery mode is pivotal in clinical handling of these pregnancies. …”
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“…While proinflammatory cytokines proved to have a pivotal role in the development and progression of HFrEF, less attention has been paid to the cellular immunity. …”
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“…Lastly, selective blockage of CCR1/CCR5 (Met-RANTES therapy) in chronically infected ccl3(+/+) mice reversed pivotal electrical abnormalities (bradycardia, prolonged PR, and QTc interval), in correlation with reduced TNF and, mainly, CCL3 levels in the heart tissue. …”
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“…Different SERCA isoforms have been described (SERCA1, 2, and 3) with SERCA2 playing a pivotal role in Ca(2+) homeostasis in cardiovascular tissues. …”
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“…Mounting evidence is associating early trauma exposure with alterations in stress sensitive areas, like the hippocampus, and abnormal concentrations of the main stress hormone, cortisol. As hippocampus is a pivotal brain region in the hypothalamus–pituitary–adrenal (HPA) axis regulation of cortisol, better understanding the relationship between childhood trauma, hippocampus structure and cortisol concentration would help clarify how childhood trauma exposure can increase the risk of developing psychosis later on in life. …”
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“…In the setting of a long-standing continuing emergency like the present Covid-19 outbreak, the integration, interaction and team work of the “out-of-hospital” and “in-hospital” systems have a pivotal role. The present study reports how the rapid and coordinated reorganization of both might help in facing such a disaster. …”
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“…Rigid bronchoscopy and safety use of current stenting devices may have the pivotal role in the conservative management of ACs, avoiding perilous situation of surgery for AC. …”
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“…GLUT1-mediated glucose uptake is a transient and rapid process; thus, the real-time monitoring of GLUT1 trafficking is pivotal for a better understanding of GLUT1 expression and GLUT1-dependent glucose uptake. …”
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“…CONCLUSION: Cathepsin K expression and Nox4/NF-κB signaling pathway were suppressed by the elevated expression of miR-92b-3p. This inhibition was pivotal in the protective effect of RES against osteoporosis induced by estrogen deficiency in both ovaries. …”
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“…BACKGROUND: The nine-valent human papillomavirus (9vHPV) vaccine protects against infection and disease related to HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58. The pivotal 36-month Phase III immunogenicity study of 9vHPV vaccine in 9- to 15-year-old girls and boys was extended to assess long-term immunogenicity and effectiveness through approximately 10 years after vaccination. …”
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“…Since parents play a pivotal role in treatment, they are an optimal group to engage in improving the resources and support available to them. …”
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“…Responses from the focus groups clearly reflected the difficulty imposed on an already stretched, understaffed workforce in pivoting to rapidly address the expected surge in demand from patients related to the pandemic. …”
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“…Among cytokines involved in SLE pathogenesis, interferons (particularly IFN-α) and interleukin 34 play a pivotal role. Interestingly, the gene signatures of type III (IFN-λ1) and type I IFNs may overlap. …”
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“…Most known phytohormones have been implicated in regulating these defenses, with jasmonates (JAs) playing a pivotal role in complex regulatory networks of signaling interactions, often generically referred to as “cross talk.” …”
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