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  1. 32421
    “…The cytokinin (CK) response regulator (RR) gene family plays a pivotal role in regulating the developmental and environmental responses of plants. …”
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    Genome-Wide Identification and Expression Analysis of Cytokinin Response Regulator (RR) Genes in the Woody Plant Jatropha curcas and Functional Analysis of JcRR12 in Arabidopsis
  2. 32422
    “…The treatment seems safe and moderate-mild stage AD should be target population of pivotal clinical trial with 120% RMT rTMS.…”
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    Randomized, sham-controlled, clinical trial of repetitive transcranial magnetic stimulation for patients with Alzheimer’s dementia in Japan
  3. 32423
    por Zhu, Yan, Hu, Xiche
    Publicado 2022
    “…Protein kinases are key enzymes that catalyze the covalent phosphorylation of substrates via the transfer of the γ-phosphate of ATP, playing a crucial role in cellular proliferation, differentiation, and various cell regulatory processes. Due to their pivotal cellular role, the aberrant function of kinases has been associated with cancers and many other diseases. …”
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    Molecular Recognition of FDA-Approved Small Molecule Protein Kinase Drugs in Protein Kinases
  4. 32424
    “…Synovial inflammation has recently been recognized as a pivotal factor in the pathogenesis of OA. However, there is a lack of data on synovial profiles after ACL or meniscus injuries, which may contribute to PTOA. …”
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    Construction and analysis of a lncRNA–miRNA–mRNA competing endogenous RNA network from inflamed and normal synovial tissues after anterior cruciate ligament and/or meniscus injuries
  5. 32425
    “…As small non-coding RNAs, microRNAs (miRs) have pivotal roles in cancer biology. The current study aimed to systematically review the current knowledge about the significance of PD-L1-inhibiting miRs in NSCLC inhibition and their underlying mechanisms. …”
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    A scoping review on the significance of programmed death-ligand 1-inhibiting microRNAs in non-small cell lung treatment: A single-cell RNA sequencing-based study
  6. 32426
    “…Stability of grain yield is a pivotal purpose of plant breeders to improve wheat production and ensure global food security especially under abrupt climate change. …”
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    Assessing performance and stability of yellow rust resistance, heat tolerance, and agronomic performance in diverse bread wheat genotypes for enhancing resilience to climate change under Egyptian conditions
  7. 32427
    “…Background: Inflammation plays a pivotal role in the etiopathology of Major Depressive Disorder (MDD), at least in a subset of patients. …”
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    Cardiolipin Antibody: A Potential Biomarker for Depression
  8. 32428
    “…The results of molecular docking showed that the active components of B. striata have good binding activities to the pivotal targets epidermal growth factor receptor (EGFR) and PIK3CA. …”
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    The potential mechanism of Bletilla striata in the treatment of ulcerative colitis determined through network pharmacology, molecular docking, and in vivo experimental verification
  9. 32429
    “…Good postoperative pain control is pivotal for unremarkable recovery and shorter hospital stays. …”
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    An Observational Study to Assess Postoperative Pain Control and Formulate a Comprehensive Approach to the Implementation of Policy Change for Pain Control in Postoperative Units
  10. 32430
    “…MAPK-associated lncRNAs may play pivotal roles in malignant phenotypes of pancreatic cancer, and as such might represent both potentially valid therapeutic targets and diagnostic biomarkers.…”
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    Long Non-Coding RNAs Associated with Mitogen-Activated Protein Kinase in Human Pancreatic Cancer
  11. 32431
    “…SIMPLE SUMMARY: The TSSK1B gene has been demonstrated to play pivotal roles during spermatogenesis and is associated with male fertility. …”
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    The Biological Characteristics and Differential Expression Patterns of TSSK1B Gene in Yak and Its Infertile Hybrid Offspring
  12. 32432
    “…CONCLUSIONS: Health coaches’ support in delivery of key components of the program seems to be pivotal. To improve the understanding and use of BCTs in digital interventions, it is important to consider routes of delivery that offer additional interactive human support. …”
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    How the Behavior Change Content of a Nationally Implemented Digital Diabetes Prevention Program Is Understood and Used by Participants: Qualitative Study of Fidelity of Receipt and Enactment
  13. 32433
    “…Numerous studies have shown that miRNAs have pivotal roles in the occurrence and development of myocardial fibrosis (MF). …”
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    Bioinformatics prediction and experimental verification of a novel microRNA for myocardial fibrosis after myocardial infarction in rats
  14. 32434
    “…Since an early treatment could beneficially influence hearing outcome, understanding the possible etiology plays a pivotal role in orienting the most appropriate treatment. …”
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    Vestibular assessment in sudden sensorineural hearing loss: Role in the prediction of hearing outcome and in the early detection of vascular and hydropic pathomechanisms
  15. 32435
    “…Voltage-gated sodium (Na(V)) channels play a pivotal role in initiation and propagation of the neuronal action potential and Na(V)1.1, Na(V)1.2, Na(V)1.6 and Na(V)1.7 are associated with the intractable epilepsies and pain conditions. …”
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    Beyond CBD: Inhibitory effects of lesser studied phytocannabinoids on human voltage-gated sodium channels
  16. 32436
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    Spectroscopy of short-lived radioactive molecules
  17. 32437
    “…The goals set in European legislation have been pivotal drivers in enhancing waste management and stimulating innovation in recycling. …”
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    The Impact of Biotechnologically Produced Lactobionic Acid in the Diet of Lactating Dairy Cows on Their Performance and Quality Traits of Milk
  18. 32438
    “…BACKGROUND: The presence of antiphospholipid antibodies (aPLs) plays a pivotal role in the pathogenesis of antiphospholipid antibody syndrome (APS). …”
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    Prevalence and diagnostic value of non-criteria antiphospholipid antibodies for antiphospholipid syndrome in Chinese patients
  19. 32439
    por Bai, Yan-Ming, Liang, Shuang, Zhou, Bo
    Publicado 2023
    “…BACKGROUND: The occurrence and progression of hepatic fibrosis (HF) is accompanied by inflammatory damage. Immune genes play a pivotal role in fibrogenesis and inflammatory damage in HF by regulating immune cell infiltration. …”
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    Revealing immune infiltrate characteristics and potential immune-related genes in hepatic fibrosis: based on bioinformatics, transcriptomics and q-PCR experiments
  20. 32440
    “…BACKGROUND: Cancer-related cognitive decline is a serious problem in long-term survival but no pivotal study has investigated whether checkpoint inhibitors (ICI) may be associated with cognitive adverse events. …”
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    Cognitive adverse events in patients with lung cancer treated with checkpoint inhibitor monotherapy: a propensity score-matched analysis
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