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  1. 32461
    “…BMP ligands and receptors are expressed in a cell-dependent manner in the ovary and have a pivotal role in female fertility. Throughout folliculogenesis, BMPs commonly inhibit follicle-stimulating hormone (FSH)-induced progesterone production, and oocyte-derived factors BMP-6 and BMP-15 are known to act on GCs through BMP receptors and suppress FSH-induced progesterone synthesis. …”
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    FRI392 Functional Interrelationship Between Oxytocin And Bone Morphogenetic Proteins In Ovarian Steroidogenesis By Granulosa Cells
  2. 32462
    “…These results support TransCon CNP at 100 μg CNP/kg/week in the ongoing pivotal trial. FUNDING: Ascendis Pharma, A/S.…”
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    Once-weekly TransCon CNP (navepegritide) in children with achondroplasia (ACcomplisH): a phase 2, multicentre, randomised, double-blind, placebo-controlled, dose-escalation trial
  3. 32463
    “…Conclusions FASD closure emerges as a pivotal alternative for intricate scenarios involving secundum ASD coupled with concurrent comorbidities, offering individualized tailored solutions. …”
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    Fenestration: Integrating Wings Into the Atrial Septal Occluder for Navigating a Challenging Terrain
  4. 32464
    “…CONCLUSION: Tucatinib treatment in the real-world setting was associated with a similar median rwTTD, rwTTNT, and rwOS as in the pivotal HER2CLIMB trial, with particular effectiveness in patients in the 2L/3L setting. …”
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    Real-world patient characteristics, treatment patterns, and clinical outcomes associated with tucatinib therapy in HER2-positive metastatic breast cancer
  5. 32465
    “…ABSTRACT: Background: Astragaloside IV (AS-IV) is a pivotal contributor to anti-tumour effects and has garnered extensive attention in research. …”
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    Astragaloside IV Attenuates Programmed Death-Ligand 1-Mediated Immunosuppression during Liver Cancer Development via the miR-135b-5p/CNDP1 Axis
  6. 32466
    “…Thus, comprehending the biological mechanisms by which viruses infect hosts is pivotal for disease control and prevention. Currently, the molecular mechanisms of the cell signaling pathways affected by BVDV infection remain unclear. …”
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    Integrative Transcriptomics and Proteomics Analysis Reveals Immune Response Process in Bovine Viral Diarrhea Virus-1-Infected Peripheral Blood Mononuclear Cells
  7. 32467
    “…Bioinformatics analysis and further functional experiments verified that the tdDPC-EV-regulated KLF4/VEGFA axis is pivotal in accelerating wound healing. CONCLUSIONS: 3D cultivation can be utilized as an innovative optimization strategy to effectively develop DPC-derived EVs for the treatment of skin wounds. tdDPC-EVs significantly enhance wound healing via KLF4/VEGFA-driven angiogenesis.…”
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    Extracellular vesicles from 3D cultured dermal papilla cells improve wound healing via Krüppel-like factor 4/vascular endothelial growth factor A -driven angiogenesis
  8. 32468
    “…Even though hop tests are not used in isolation to evaluate readiness to RTS, their interpretation needs consideration in the decision-making process of returning to pivoting sports. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40798-023-00656-7.…”
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    Are We Jumping to the Wrong Conclusions? Longer Jumps and More Hops in Female Football Players Who Went on to Sustain a Primary or Secondary ACL Injury Compared to Those Who Did Not
  9. 32469
    por Koonin, Eugene V
    Publicado 2006
    “…Perhaps, most importantly, I argue that the intron invasion triggered other pivotal events of eukaryogenesis, including the emergence of the spliceosome, the nucleus, the linear chromosomes, the telomerase, and the ubiquitin signaling system. …”
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    The origin of introns and their role in eukaryogenesis: a compromise solution to the introns-early versus introns-late debate?
  10. 32470
    “…The placenta produces pivotal hormones and cytokines for communication between cotyledonary villi and the maternal caruncle. …”
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    Global gene expression analysis and regulation of the principal genes expressed in bovine placenta in relation to the transcription factor AP-2 family
  11. 32471
    por John, Swen Malte
    Publicado 2008
    “…Concepts underpinning these initiatives include multidisciplinary skin protection teaching programs for various high-risk professions, which turned out to be pivotal for the success of these projects. A corollary of this work is a nationwide multi-step intervention approach currently implemented by the public statutory insurance system. …”
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    Occupational skin diseases: options for multidisciplinary networking in preventive medicine
  12. 32472
    “…Conversely, factors secreted by the VE play pivotal roles that cannot be attributed to the DE in early axis formation, heart formation and the patterning of the anterior nervous system. …”
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    A Comparative Analysis of Extra-Embryonic Endoderm Cell Lines
  13. 32473
    “…The investigation of the isotopic signatures of Pinus sylvestris L. emphasizes the pivotal role of the intra-seasonal dynamics in carbon metabolism through the transport of assimilates from autotrophic (needles) to heterotrophic (twigs) organs of the studied trees. …”
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    Intra-seasonal dynamics in metabolic processes of (13)C/(12)C and (18)O/(16)O in components of Scots pine twigs from southern Siberia interpreted with a conceptual framework based on the Carbon Metabolism Oscillatory Model
  14. 32474
    “…On the other hand, micro RNAs (miRNAs) are short ribonucleic acids which have also been found to play a pivotal role in cancer pathogenesis. The role of miRNA in progestin-induced breast cancer is poorly explored. …”
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    Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development
  15. 32475
    “…BACKGROUND: Calcium (Ca2+) handling proteins are known to play a pivotal role in the pathophysiology of cardiomyopathy. …”
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    Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data
  16. 32476
    “…Rheumatoid arthritis (RA) is characterized by auto-antibodies overproduction such as rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody, suggesting a pivotal role of Tfh cell and B cell in the pathogenesis of RA. …”
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    A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis
  17. 32477
    “…Antioxidants such as vitamin E have been postulated to be pivotal in this process, as vitamin E is able to protect the growing brain from oxidative stress. …”
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    The effects of prenatal and early postnatal tocotrienol-rich fraction supplementation on cognitive function development in male offspring rats
  18. 32478
    por Root, Robin, Whiteside, Alan
    Publicado 2013
    “…CONCLUSIONS: PLWHA reports of care supporter practices that enabled ART adherence demonstrated the pivotal role that CHBC plays in many PLWHA lives, especially in hard to reach areas. …”
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    A qualitative study of community home-based care and antiretroviral adherence in Swaziland
  19. 32479
    “…The release of other ADAM17 substrates, TGFα and sMet, are also regulated this way, pointing to a general impact on the release of ADAM17 substrates, which are pivotal for liver regeneration and function. In parallel, UDCA upregulates TIMP-1 that in turn inhibits matrix metalloproteinases, which destroy the hepatic ECM in diseased liver. …”
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    Liver protective effect of ursodeoxycholic acid includes regulation of ADAM17 activity
  20. 32480
    “…DISCUSSION: The BASIC-HHD study is designed to assemble pivotal information on dialysis modality choice and uptake, investigating users, care-givers and care delivery processes and study their variation in a multi-layered analytical approach within a single health care system. …”
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    Barriers to successful implementation of care in home haemodialysis (BASIC-HHD):1. Study design, methods and rationale
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