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32561por Pardo, Laura Suarez, Hughes, Christine, Ehlers, Shawna, Dunlay, Shannon, Staab, Jeffrey“…Social Life and Routines, included the most common themes described by patients and the difficulties experienced within this category. Themes about the pivotal role of socialization and social support that were lost during the pandemic commonly emerged. …”
Publicado 2022
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32562“…Although normal operation and services in many libraries have been greatly disrupted, academic libraries in the United States were reportedly responding to challenges by pivoting to new ways to meet the users’ needs. This observational study was designed to investigate the status, services, and resources disclosed via websites of academic medical/health sciences libraries (MHSLs) in the United States and document how they adapted and continued to provide support to help fight the health crisis and the resulting “infodemic” through various means. …”
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32563por Ferreira, Bárbara Roque, Pio-Abreu, José Luís, Figueiredo, Américo, Misery, Laurent“…The etiopathogenesis of pruritus in those disorders sheds light on the link among psychopathological features, psychological stress and the subtle interface between allergic and autoimmune mechanisms, where mast cells play a pivotal role. Allergy has long been recognised as an altered reactivity to exogenous antigens (allergens), defined as an immediate hypersensitivity mediated by immunoglobulin E (IgE). …”
Publicado 2021
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32564por Estrada, Uma Maria Lal-Trehan, Meeks, Grant, Salazar-Marioni, Sergio, Scalzo, Fabien, Farooqui, Mudassir, Vivanco-Suarez, Juan, Gutierrez, Santiago Ortega, Sheth, Sunil A., Giancardo, Luca“…In stroke care, the extent of irreversible brain injury, termed infarct core, plays a key role in determining eligibility for acute treatments, such as intravenous thrombolysis and endovascular reperfusion therapies. Many of the pivotal randomized clinical trials testing those therapies used MRI Diffusion-Weighted Imaging (DWI) or CT Perfusion (CTP) to define infarct core. …”
Publicado 2022
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32565por Hameed, Ishaque, Khan, Mohammad O, Ul-Haque, Ibtehaj, Siddiqui, Omer M, Samad, Syed A, Malik, Shanza, Mahmood, Samar“…The final analysis included 11 articles, consisting of 10 observational studies and a pivotal trial. Cumulative results revealed that the TAo approach had a significantly lower incidence of vascular complications (RR = 2.30; 95% CI = 1.22 to 4.35), and the need for implantation of a permanent pacemaker (RR = 1.82; 95% CI = 1.30 to 2.54) along with a lower amount of contrast (mean difference (MD) = 27.40; 95% CI = 3.73 to 51.08) needed to be used. …”
Publicado 2022
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32566por Jee, ByulA, Seo, Eunjeong, Park, Kyunghee, Kim, Yi Rang, Byeon, Sun-ju, Lee, Sang Min, Chung, Jae Hoon, Song, Wan, Sung, Hyun Hwan, Jeon, Hwang Gyun, Jeong, Byong Chang, Seo, Seong Il, Jeon, Seong Soo, Lee, Hyun Moo, Park, Se Hoon, Park, Woong-Yang, Kang, Minyong“…Further analysis of the subtype 2 population demonstrated that GATM (glycine amidinotransferase), as a novel gene associated with PBRM1 mutation, plays a pivotal role in ccRCC by using a cell culture model, revealing tumor, suppressive-like features in reducing proliferation and migration. …”
Publicado 2022
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32567por Long, Jing, Teng, Bin, Zhang, Wei, Li, Long, Zhang, Ming, Chen, Yingqi, Yao, Zhenyu, Meng, Xiangbo, Wang, Xinluan, Qin, Ling, Lai, Yuxiao“…All these results showed that the Mg ion concentration of intraperitoneally-injected extract solutions was a determinant of mouse survival, and a high Mg ion concentration (more than 240 mM) was the pivotal factor contributing to the death of the mice, while changes in pH value showed a negligible effect. …”
Publicado 2021
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32568por Sting, Reinhard, Geiger, Claudia, Rietschel, Wolfram, Blazey, Birgit, Schwabe, Ingo, Rau, Jörg, Schneider-Bühl, Lisa“…While post-mortem examinations and isolation of the pathogen are pivotal for a proven diagnosis, serological examinations are the basis of epidemiological and monitoring studies. …”
Publicado 2022
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32569por Ma, Zhi, Yang, Huixia, Kessler, Mirjana, Sperandio, Markus, Mahner, Sven, Jeschke, Udo, von Schönfeldt, Viktoria“…BACKGROUND: Carbohydrate Lewis antigens including sialyl Lewis A (sLeA), sialyl Lewis X (sLeX), Lewis X (LeX), and Lewis Y (LeY) are the commonest cell surface glycoconjugates that play pivotal roles in multiple biological processes, including cell adhesion and cell communication events during embryogenesis. …”
Publicado 2022
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32570por Michaeli, Daniel Tobias, Mills, Mackenzie, Michaeli, Thomas, Miracolo, Aurelio, Kanavos, Panos“…Initial indications’ pivotal trials tended to be shorter (AOR per month: 0.96, 95%CI [0.93–0.99], p < 0.05), of lower phase design (AOR per clinical phase: 0.28, 95%CI [0.09–0.85], p < 0.05), and enroll more patients (AOR per 100 patients: 1.19, 95%CI [1.01–1.39], p < 0.05). …”
Publicado 2022
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32571“…Alpha‐ketoglutarate (Alpha‐KG), a precursor of glutamine, is known as a crucial intermediate of the TCA cycle and plays a pivotal role in multiple metabolic processes. As a precursor of glutamate and glutamine, AKG acts as an antioxidant agent as it directly reacts with hydrogen peroxide with formation of succinate, water, and carbon dioxide; meanwhile, it discharges plenty of ATP by oxidative decarboxylation. …”
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32572por Yun, Ke, Zhang, Shuang, Yang, Xiaotao, Man, Dongliang, Yao, Jialiang, Wang, Wei, Han, Xiaoxu“…BACKGROUND: Dyslipidemia is a significant threat to global public health due to its pivotal role as a cardiovascular disease (CVD) risk factor. …”
Publicado 2022
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32573por Cidade, José Pedro, Coelho, LM, Costa, Vasco, Morais, Rui, Moniz, Patrícia, Morais, Luís, Fidalgo, Pedro, Tralhão, António, Paulino, Carolina, Nora, David, Valério, Bernardino, Mendes, Vítor, Tapadinhas, Camila, Povoa, Pedro“…Therefore, clear clinical criteria are pivotal for early recognition of patients more likely to need prompt organ support. …”
Publicado 2022
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32574por Li, Xin-Wei, Zhang, Ming-Yuan, Li, Zhi-Jun, Ai, Li-Zhe, Jin, Meng-Di, Jia, Ning-Ning, Xie, Meng-Tong, Yang, Yu-Qing, Li, Wei-Zhen, Dong, Lin, Yu, Qiong“…Meanwhile, maternal nutrition during pregnancy is a pivotal environmental factor in the development of SCZ. …”
Publicado 2022
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32575por Clark, Kenneth, Brunst, Caroline, Dibartola, Alex, Cavendish, Parker, Milliron, Eric, Kaeding, Christopher, Duerr, Robert, Magnussen, Robert, Flanigan, David, Swinehart, Steven“…Strength symmetry is a RTP criteria when considering return to cutting and pivoting sports. Isokinetic dynamometry testing is often done for ACL reconstruction recovery but there is currently little literature on its use in meniscal repair protocols for RTP. …”
Publicado 2022
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32576“…However, data from an internet search engine (eg, Google) is less studied, although they can provide pivotal real-time surveillance information. The internet data can be employed to improve forecasting performance and provide early warning, especially during the epidemic. …”
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32577“…Nevertheless, predicting immunotherapy responses in BC is still essential. LncRNAs play pivotal roles in cancer development through diverse oncogenic signal pathways. …”
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32578por Naumann-Winter, Frauke, Wolter, Franziska, Hermes, Ulrike, Malikova, Eva, Lilienthal, Nils, Meier, Tania, Kalland, Maria Elisabeth, Magrelli, Armando“…Furthermore, external data were considered pivotal for marketing authorization only exceptionally and only for active substances already in use within the specific therapeutic indication. …”
Publicado 2022
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32579por Evsevieva, Maria, Sergeeva, Oksana, Mazurakova, Alena, Koklesova, Lenka, Prokhorenko-Kolomoytseva, Irina, Shchetinin, Evgenij, Birkenbihl, Colin, Costigliola, Vincenzo, Kubatka, Peter, Golubnitschaja, Olga“…Pre-pregnancy check-up focused on sub-optimal health and utilising here described phenotypes is pivotal for advanced health policy. PLAIN ENGLISH ABSTRACT: Cardiovascular health is decisive for reproductive function and healthy pregnancy. …”
Publicado 2022
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32580“…ABSTRACT: Ferroptosis is a new type of programmed cell death that plays a pivotal role in a variety of tumors. Moreover, immunity is closely related to ferroptosis. …”
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