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  1. 32621
    “…We further probed mitophagy's pivotal role in PS-NP-induced mitochondrial damage and examined melatonin's ameliorative potential in vitro. …”
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    Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo
  2. 32622
    “…CONCLUSION: This study provides class III evidence of effectiveness and tolerability of galcanezumab in patients with HFEM and CM with comorbidities that would result in exclusion of the pivotal RCTs. Nonetheless, the clinical results over a 12-month period were similar to the efficacy observed in randomized controlled trials. …”
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    Long-term effectiveness and tolerability of galcanezumab in patients with migraine excluded from clinical trials: real world evidence of 1055 patients with 1 year follow-up from the Galca-Only registry
  3. 32623
    “…CONCLUSIONS: The m(6)A regulators exerted a pivotal impact on hepatic IRI. The m(6)A patterns that found in this study might provide novel targets and strategies for the alleviation/treatment of hepatic IRI in the future. …”
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    Key m(6)A regulators mediated methylation modification pattern and immune infiltration characterization in hepatic ischemia-reperfusion injury
  4. 32624
    “…The myxovirus resistance (Mx) proteins belong to interferon-induced dynamin GTPase and play pivotal role in the inhibition of replication of numerous viruses. …”
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    Molecular cloning, GTP recognition mechanism and tissue-specific expression profiling of myxovirus resistance (Mx) protein in Labeo rohita (Hamilton) after Poly I:C induction
  5. 32625
    “…These plasma biomarker results are in good agreement with prior neuropathology studies and indicate that the third and fourth decades (i.e., 20 to 40 years of age) of life are pivotal periods during which AD processes manifest in DS. …”
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    Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase
  6. 32626
    “…CONCLUSIONS: Our results disclose SH3BGRL as a novel posttranslational modulator of HER2 hyperactivation, which can lead to the intrinsic resistance to HER2-targeted therapy. SH3BGRL would be a pivotal therapy target and a diagnostic marker to HER2-positve patients. …”
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    SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane
  7. 32627
    “…Of these women, 1285 were assessed after January 20, 2020, when the coronavirus epidemic was publicly declared and 2839 were assessed before this pivotal time point. The internationally recommended Edinburgh Postnatal Depression Scale was used to assess maternal depression and anxiety symptoms. …”
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    Perinatal depressive and anxiety symptoms of pregnant women during the coronavirus disease 2019 outbreak in China
  8. 32628
    “…CONCLUSION: RIPK1 plays a pivotal role in TLR3 ligand, Poly(I:C)-induced cell death when cIAPs activity was inhibited and loss of RIPK1 enhanced Poly(I:C)-induced invasion which was partially reversed by Smac mimetic. …”
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    Receptor-interacting protein kinase 1 is a key mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3 ligand-promoted invasion in cholangiocarcinoma
  9. 32629
    “…BACKGROUND: MiRNAs act as pivotal post-transcriptional gene mediators in the regulation of diverse biological processes, including proliferation, development and apoptosis. …”
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    Effects of miR-101-3p on goat granulosa cells in vitro and ovarian development in vivo via STC1
  10. 32630
    “…METHODS: Data from the pivotal trial assessing cladribine tablets vs placebo (CLARITY) were propensity score matched to data from the Italian multicenter database i-MuST. …”
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    Cladribine vs other drugs in MS: Merging randomized trial with real-life data
  11. 32631
    “…Therefore, we recommend employers to ensure that workplace health and safety programs account for workers’ level of education and work experience. It is also pivotal to provide workers witha suitable PPE and instructions on its use, and to arrange safety communication in the local languages at the relevant workplaces. …”
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    Low levels of knowledge and practice of occupational hazards among flower farm workers in southwest Shewa zone, Ethiopia: a cross-sectional analysis
  12. 32632
    “…INTRODUCTION: Following pivotal trials, real-world evidence is important to assess the impact of new drugs in everyday clinical practice. …”
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    Comparative Effectiveness of Switching From First-Generation Basal Insulin to Glargine 300 U/ml or Degludec 100 U/ml in Type 1 Diabetes: The RESTORE-1 Study
  13. 32633
    “…BACKGROUND: Parents play a pivotal role in adolescent sexual health and Human Papillomavirus (HPV) vaccination. …”
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    Effects of a randomized controlled trial of a brief, student-nurse led, parent-based sexual health intervention on parental protective factors and HPV vaccination uptake
  14. 32634
    “…Frontline epidemic prevention workers play a pivotal role against COVID-19. They must face high-risk infection conditions, insufficient anti-epidemic material supplies, mental pressure, and so on. …”
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    The willingness for dietary and behavioral changes in frontline epidemic prevention workers after experiencing the outbreak of COVID-19 in China: a cross-sectional study
  15. 32635
    “…Community-level involvement with pivotal role played by community health workers has been one of the major reasons for the success of many ongoing policies. …”
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    Pro-poor policies and improvements in maternal health outcomes in India
  16. 32636
    “…BACKGROUND: Hepatic stellate cell (HSC) activation plays a pivotal role in hepatic inflammation and liver fibrosis. …”
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    Involvement of TLR4 signaling regulated-COX2/PGE2 axis in liver fibrosis induced by Schistosoma japonicum infection
  17. 32637
    “…Appropriate perioperative fluid management is pivotal in this context; however, the most effective perioperative fluid management is still unclear. …”
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    Perioperative liberal versus restrictive fluid strategies and postoperative outcomes: a systematic review and metanalysis on randomised-controlled trials in major abdominal elective surgery
  18. 32638
    “…In this paper, we used 2-hydroxpropyl-β-cyclodextrin (HBC) as a solubilizing agent in a study of the KSTDs steady-state kinetics and demonstrated that substrate bioavailability has a pivotal impact on enzyme specificity. RESULTS: Molecular dynamics simulations on KSTD1 from Rhodococcus erythropolis indicated no difference in ΔG(bind) between the native substrate, androst-4-en-3,17-dione (AD; − 8.02 kcal/mol), and more complex steroids such as cholest-4-en-3-one (− 8.40 kcal/mol) or diosgenone (− 6.17 kcal/mol). …”
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    Universal capability of 3-ketosteroid Δ(1)-dehydrogenases to catalyze Δ(1)-dehydrogenation of C17-substituted steroids
  19. 32639
    “…BACKGROUND: Recent studies indicate that complement plays pivotal roles in promoting or suppressing cancer progression. …”
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    C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer
  20. 32640
    “…CONCLUSIONS: These results demonstrated that FMNL2 promoted cell proliferation partially by reducing p27 nuclear localization and p27 protein stability in human breast cancer cells, suggesting the pivotal role of FMNL2 in breast cancer progression. …”
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    Formin-like protein 2 promotes cell proliferation by a p27-related mechanism in human breast cancer cells
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