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  1. 32641
    “…BACKGROUND: CPX-351 (United States: Vyxeos(®); Europe: Vyxeos(®) Liposomal), a dual-drug liposomal encapsulation of daunorubicin and cytarabine in a synergistic 1:5 molar ratio, is approved by the US FDA and the EMA for the treatment of adults with newly diagnosed therapy-related acute myeloid leukemia or acute myeloid leukemia with myelodysplasia-related changes. In a pivotal phase 3 study that evaluated 309 patients aged 60 to 75 years with newly diagnosed high-risk/secondary acute myeloid leukemia, CPX-351 significantly improved median overall survival versus conventional 7 + 3 chemotherapy (cytarabine continuous infusion for 7 days plus daunorubicin for 3 days), with a comparable safety profile. …”
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    Quality-adjusted Time Without Symptoms of disease or Toxicity (Q-TWiST) analysis of CPX-351 versus 7 + 3 in older adults with newly diagnosed high-risk/secondary AML
  2. 32642
    “…Late initiation of high-intensity treatments, particularly among those with misperceived low-risk (e.g., female subjects or those with high HDL-cholesterol), appears as pivotal factors needing to be modified to improve CVD prevention. …”
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    Improving statin treatment strategies to reduce LDL-cholesterol: factors associated with targets’ attainment in subjects with and without type 2 diabetes
  3. 32643
    “…BACKGROUND: Most older patients with acute myeloid leukemia (AML) who attain morphologic remission with intensive chemotherapy (IC) will eventually relapse and post-relapse prognosis is dismal. In the pivotal QUAZAR AML-001 trial, oral azacitidine maintenance therapy significantly prolonged overall survival by 9.9 months (P < 0.001) and relapse-free survival by 5.3 months (P < 0.001) compared with placebo in patients with AML in first remission after IC who were not candidates for transplant. …”
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    Management of adverse events in patients with acute myeloid leukemia in remission receiving oral azacitidine: experience from the phase 3 randomized QUAZAR AML-001 trial
  4. 32644
    “…BACKGROUND: Insecticide-treated nets (ITNs) access-use has been pivotal monitoring indicator for malaria prevention and control, particularly in resource limited settings. …”
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    Comparing insecticide-treated nets access-use based on universal household and population indicators vis-a-vis measures adapted to sleeping spaces in Ethiopia
  5. 32645
    “…Herein, we aimed to assess semaphorin 4C (SEMA4C), a pivotal protein involved in breast cancer progression, as a serum diagnostic biomarker. …”
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    Serum semaphorin 4C as a diagnostic biomarker in breast cancer: A multicenter retrospective study
  6. 32646
    “…The clinicians should play a pivotal role to improve antenatal care follow up, counsel, and supplement recommended diets and minimize violence and abuse during pregnancy. …”
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    Determinants of adverse birth outcomes among women delivered in public hospitals of Ethiopia, 2020
  7. 32647
    “…Formation of a stable binding interface between the Receptor Binding Domain (RBD) of SARS-CoV-2 Spike (S) protein and Angiotensin-Converting Enzyme 2 (ACE2) of host is pivotal for viral entry. RBD has been shown to mutate frequently during pandemic. …”
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    Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interaction
  8. 32648
    “…CONCLUSION: This study shows that pericyte but not astrocyte HIF-1 stabilization modulates endothelial tight junction functionality and thereby plays a pivotal role in hypoxia-induced vascular dysfunction. …”
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    Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo
  9. 32649
    “…However, patients with cancer were excluded from pivotal clinical trials. Early data suggest that vaccine response is less robust in patients with immunosuppressive conditions or treatments, while toxicity and acceptability of COVID-19 vaccines in the cancer population is unknown. …”
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    Protocol for SARS-CoV-2 post-vaccine surveillance study in Australian adults and children with cancer: an observational study of safety and serological and immunological response to SARS-CoV-2 vaccination (SerOzNET)
  10. 32650
    “…BACKGROUND: Endotheliopathy is suggested as pivotal pathophysiology of sepsis and trauma-associated organ failure, but its role in acute respiratory failure is not yet determined. …”
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    Endotheliopathy is associated with slower liberation from mechanical ventilation: a cohort study
  11. 32651
    “…CONCLUSIONS: (1) Despite the number of prescriptions was reduced because of the pandemic, the lipid control was not affected. (2) Half of the patients treated with PSCK9i is due to statins intolerance and the 86% is for secondary prevention. (2) The reduction results were similar to pivotal clinical trials. Despite this, 39% of the total of the patients and 60% of patients with dual teraphy did not reach the goal of ESC/EAS guidelines (< 55 mg/dL and/or reduction > 50%). …”
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    Impacto de la pandemia por COVID-19 en el control lipídico de pacientes que inician inhibidores de la PCSK9
  12. 32652
    “…CONCLUSION: This study provided evidence that SRH service use prevalence increased over time in Uganda and highlights the importance of studying SRH and the different disability types when examining SDH. The SDH are pivotal to the attainment of universal health coverage, including SRH services, for all people irrespective of their social identities.…”
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    Disability and sexual and reproductive health service utilisation in Uganda: an intersectional analysis of demographic and health surveys between 2006 and 2016
  13. 32653
    “…BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is a process linked to metastasis and drug resistance with non-coding RNAs (ncRNAs) playing pivotal roles. We previously showed that miR-100 and miR-125b, embedded within the third intron of the ncRNA host gene MIR100HG, confer resistance to cetuximab, an anti-epidermal growth factor receptor (EGFR) monoclonal antibody, in colorectal cancer (CRC). …”
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    Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m(6)A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression
  14. 32654
    “…We also observed a dose-dependent accumulation of polyubiquitinated proteins and loss of proteasomal function in CuO NP-exposed cells, and we could demonstrate misfolding and mitochondrial translocation of superoxide dismutase 1 (SOD1), a Cu/Zn-dependent enzyme that plays a pivotal role in the defense against oxidative stress. …”
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    Copper oxide nanoparticles trigger macrophage cell death with misfolding of Cu/Zn superoxide dismutase 1 (SOD1)
  15. 32655
    “…BACKGROUND: Advanced glycation end-products (AGEs) and their interaction with the receptor for advanced glycation end-products (RAGE) play a pivotal role in the development and progression of type 2 diabetes. …”
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    Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: a retrospective cohort study
  16. 32656
    por Gilles, Liese, Govarts, Eva, Rodriguez Martin, Laura, Andersson, Anna-Maria, Appenzeller, Brice M. R., Barbone, Fabio, Castaño, Argelia, Coertjens, Dries, Den Hond, Elly, Dzhedzheia, Vazha, Eržen, Ivan, López, Marta Esteban, Fábelová, Lucia, Fillol, Clémence, Franken, Carmen, Frederiksen, Hanne, Gabriel, Catherine, Haug, Line Småstuen, Horvat, Milena, Halldórsson, Thórhallur Ingi, Janasik, Beata, Holcer, Nataša Janev, Kakucs, Réka, Karakitsios, Spyros, Katsonouri, Andromachi, Klánová, Jana, Kold-Jensen, Tina, Kolossa-Gehring, Marike, Konstantinou, Corina, Koponen, Jani, Lignell, Sanna, Lindroos, Anna Karin, Makris, Konstantinos C., Mazej, Darja, Morrens, Bert, Murínová, Ľubica Palkovičová, Namorado, Sónia, Pedraza-Diaz, Susana, Peisker, Jasmin, Probst-Hensch, Nicole, Rambaud, Loïc, Rosolen, Valentina, Rucic, Enrico, Rüther, Maria, Sarigiannis, Dimosthenis, Tratnik, Janja Snoj, Standaert, Arnout, Stewart, Lorraine, Szigeti, Tamás, Thomsen, Cathrine, Tolonen, Hanna, Eiríksdóttir, Ása, Van Nieuwenhuyse, An, Verheyen, Veerle J., Vlaanderen, Jelle, Vogel, Nina, Wasowicz, Wojciech, Weber, Till, Zock, Jan-Paul, Sepai, Ovnair, Schoeters, Greet
    Publicado 2022
    “…Human biomonitoring has become a pivotal tool for supporting chemicals’ policies. It provides information on real-life human exposures and is increasingly used to prioritize chemicals of health concern and to evaluate the success of chemical policies. …”
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    Harmonization of Human Biomonitoring Studies in Europe: Characteristics of the HBM4EU-Aligned Studies Participants
  17. 32657
    “…Cardiac function in early sepsis is pivotal in determining survival; hyperdynamic left ventricular ejection fraction is associated with higher mortality. …”
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    Sex-specific differences in cardiac function, inflammation and injury during early polymicrobial sepsis
  18. 32658
    “…CONCLUSIONS: The descending facilitation function mediated by CX3CL1 and its downstream cascade may play a pivotal role, leading to enhanced pain sensitization and even mirror-image pain. …”
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    Neuroinflammation in the anterior cingulate cortex: the potential supraspinal mechanism underlying the mirror-image pain following motor fiber injury
  19. 32659
    por Sohn, Eun Jung
    Publicado 2022
    “…CONCLUSIONS: PIK3R3 plays a pivotal role in ovarian cancer development and is therefore a potential candidate for developing novel therapeutic approaches. …”
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    PIK3R3, a regulatory subunit of PI3K, modulates ovarian cancer stem cells and ovarian cancer development and progression by integrative analysis
  20. 32660
    “…OBJECTIVES: Tumour size measurement is pivotal for staging and stratifying patients with pancreatic ductal adenocarcinoma (PDA). …”
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    Fractal analysis improves tumour size measurement on computed tomography in pancreatic ductal adenocarcinoma: comparison with gross pathology and multi-parametric MRI
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