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  1. 32681
    “…Background: Inflammation plays a pivotal role in the pathophysiology of asthma. Free light chains (FLC) can cause inflammation by mast cell antigen-activation. …”
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    Elevated serum polyclonal immunoglobulin free light chains in patients with severe asthma
  2. 32682
    “…IgA antibodies play a pivotal role in neutralising, eliminating, and regulating potential pathogens and microorganisms in the gut.…”
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    Elevated levels of enteric IgA in an unimmunised mouse model of Hyper IgM syndrome derived from gut-associated secondary lymph organs even in the absence of germinal centres
  3. 32683
    “…Exposure–response analyses based on data from the ALTA (ALK in Lung Cancer Trial of AP26113) and ALTA-1L pivotal trials of brigatinib confirm the favorable benefit versus risk profile of the approved titration dosing regimen of 180 mg once daily (after a 7-day lead-in at 90 mg once daily).…”
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    Clinical Pharmacology of Brigatinib: A Next-Generation Anaplastic Lymphoma Kinase Inhibitor
  4. 32684
    “…IRAK-4 is a serine/threonine kinase with a pivotal role in innate immune signaling from toll-like receptors and production of pro-inflammatory cytokines. …”
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    Neuroinflammation, autoinflammation, splenomegaly and anemia caused by bi-allelic mutations in IRAK4
  5. 32685
    “…In our previous study, we have reported that BMP-6 upregulates the adrenocortical steroidogenesis via the IP3 and MAPK signaling in H295R cells, suggesting that orexin may have a pivotal role as a functional modulator of BMP-6. Collectively, it was revealed that orexin enhances adrenocortical steroidogenesis by regulating BMP signaling with a feedback system in human adrenocortical cells. …”
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    SAT269 Orexin Activates Adrenocortical Steroidogenesis With Upregulation Of BMP Signaling By Human H295R Cells
  6. 32686
    “…In summary, these clinical and cellular studies highlight a pivotal role for GH in promoting mammary cellular metabolism at the onset of lactation. …”
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    THU052 Serum Growth Hormone Increases At The Onset Of Lactation And Promotes Mitochondrial Activity In Human Mammary Cells
  7. 32687
    “…Background Calcium plays a pivotal role in the pathogenesis of viral infections by contributing to virus development, gene expression, maturation, and release. …”
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    THU401 Impact Of Hypercalcemia On Outcomes Among Patients Admitted With COVID-19
  8. 32688
    “…The complex interplay of hydrographic conditions, ocean currents, and ecological factors emerges as pivotal in shaping the evolutionary landscape of these flatfishes. …”
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    Insights into the Mitochondrial Genetic Makeup and Miocene Colonization of Primitive Flatfishes (Pleuronectiformes: Psettodidae) in the East Atlantic and Indo-West Pacific Ocean
  9. 32689
    “…Introduction Microorganisms are pivotal contributors to pulp and periapical pathology, often culminating in endodontic treatment failures. …”
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    Efficacy of Triple Antibiotic Paste and Bromelain Paste As Intracanal Medicament Against Enterococcus faecalis: An In-Vivo Study
  10. 32690
    por Koonin, Eugene V
    Publicado 2007
    “…The cases in point include the origin of complex RNA molecules and protein folds; major groups of viruses; archaea and bacteria, and the principal lineages within each of these prokaryotic domains; eukaryotic supergroups; and animal phyla. In each of these pivotal nexuses in life's history, the principal "types" seem to appear rapidly and fully equipped with the signature features of the respective new level of biological organization. …”
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    The Biological Big Bang model for the major transitions in evolution
  11. 32691
    “…As most national policies plan to strengthen malaria control to reach the elimination of this disease, anti-malarial drugs such as the artesunate + amodiaquine fixed-dose ACT will play a pivotal role in this process. TRIAL REGISTRATION: The protocol was registered with the www.clinicaltrials.gov open clinical trial registry under the identifier number NCT00316329.…”
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    Randomized, multicentre assessment of the efficacy and safety of ASAQ – a fixed-dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria
  12. 32692
    “…We have recently established that the proteasome is a pivotal regulator of inflammation, which modulates the induction of inflammatory mediators such as TNF-α, IL-1, IL-6, and nitric oxide (NO) in response to a variety of stimuli. …”
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    Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models
  13. 32693
    “…OBJECTIVE: To examine disease surveillance in the context of a new national framework for public health quality and to solicit input from practitioners, researchers, and other stakeholders to identify potential metrics, pivotal research questions, and actions for achieving synergy between surveillance practice and public health quality. …”
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    Disease Surveillance and Achieving Synergy In Public Health Quality Improvement
  14. 32694
    “…BACKGROUND AND AIMS: The virus/host interplay mediates liver pathology in chronic HBV infection. MiRNAs play a pivotal role in virus/host interactions and are detected in both serum and HBsAg-particles, but studies of their dynamics during chronic infection and antiviral therapy are missing. …”
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    A Serum MicroRNA Signature Is Associated with the Immune Control of Chronic Hepatitis B Virus Infection
  15. 32695
    “…Patients who were involved in jumping/pivoting sports when they injured the ACL reconstructed knee and had the desire to return to the same sport at the same competitive level were included in the study. …”
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    Return to Sports and Subsequent ACL Injury Rates after Revision ACL reconstruction with Patellar Tendon Autograft
  16. 32696
    “…METHODS: Seventy-eight subjects who underwent ACLR and were ready to return to a pivoting/cutting sport (RTS) and 47 controls were prospectively enrolled. …”
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    Incidence of Second Anterior Cruciate Ligament (ACL) Injury 2 Years after Primary ACL Reconstruction and Return to Sport
  17. 32697
    “…Inflammatory factors were assessed, and the results showed that the DSS + HRW group exhibited significantly reduced levels of TNF-α, IL-6 and IL-1β compared with the DSS group (P < 0.05). In addition, the pivotal proteins involved in endoplasmic reticulum (ER) stress, including p-eIF2α, ATF4, XBP1s and CHOP, were dramatically reduced after HRW treatment in contrast to the control group (P < 0.05). …”
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    Hydrogen-rich water protects against inflammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression
  18. 32698
    “…Behavioral theories posit that information about HIV is a pivotal construct in individual risk reduction. However, measurements of knowledge have traditionally focused on ever hearing about HIV and being aware of the most common routes of spread. …”
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    Detailed Knowledge About HIV Epidemiology and Transmission Dynamics and Their Associations With Preventive and Risk Behaviors Among Gay, Bisexual, and Other Men Who Have Sex With Men in the United States
  19. 32699
    “…Therefore, the EMBLEM trial was designed to investigate whether empagliflozin treatment can improve endothelial function, which plays a pivotal role in the pathogenesis of atherosclerosis, in patients with T2DM and established CVD. …”
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    Rationale and design of a multicenter placebo-controlled double-blind randomized trial to evaluate the effect of empagliflozin on endothelial function: the EMBLEM trial
  20. 32700
    “…With the development of novel RNA in situ Hybridization method, quantitatively localization and visualization of the virus RNA molecular in cultured cell or tissue section becomes very important tool to address these pivotal pathogenic questions. In this study, we established ViewRNA ISH method to reveal the dynamic distribution of CSFV RNA in PK15 cells. …”
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    A novel ViewRNA in situ hybridization method for the detection of the dynamic distribution of Classical Swine Fever Virus RNA in PK15 cells
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