“…A collaborative and integrated team approach in which pharmacists can play a pivotal role should be sought when managing patients with diabetes. …”
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“…The findings presented here demonstrate a favorable benefit-risk profile and support the global pivotal trial now underway to evaluate the long-term treatment benefits and the potential of Trappsol® Cyclo™ as a disease-modifying treatment in this patient population.…”
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“…We present secondary analyses of hormone and height velocity (HV) data from the pivotal trial of the first small-volume, long-acting, subcutaneously administered gonadotropin-releasing hormone agonists (GnRHa) for CPP, with the goal of assessing if the study drug adequately suppresses hormones in overweight and obese children. …”
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“…Thus, we identified a cytoskeleton-modifying signaling pathway with multiple components that plays a pivotal role in whether the breast cancer cell responds to a-UPR activation and swelling by membrane rupture and necrotic cell death or reorganizes its cytoskeleton enabling the cancer cell to survive. …”
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“…To further elucidate the immune microenvironment landscape, consistent clustering analysis was conducted, yielding three subtypes, where the abundance of follicular helper T cells (p < 0.05) in subtype A, M2 macrophages (p < 0.01), neutrophils (p < 0.05) in subtype B and CD8+ T cells (p < 0.05), resting NK cells (p < 0.05), M2 macrophages (p < 0.05) in subtype C were significantly different from the control group. Additionally, three pivotal modules, designated as red, blue and green, were identified, each bearing a close association with differentially infiltrated immunocytes, as discerned by the weighted gene co‐expression network analysis (WGCNA). …”
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“…Rigorous phenotyping will be pivotal to determine which patients are at risk of progressive vasculopathic disease and in whom surveillance and recruitment to studies may be of benefit. …”
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“…CONCLUSIONS AND RELEVANCE: These findings suggest that increases in certain plasma AD biomarkers are associated with NP in WLWH and WLWOH and may be associated with later onset of AD, and measuring these biomarkers could be a pivotal advancement in monitoring aging brain health and development of AD among women with and without HIV.…”
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“…The study suggests that (1) religious leaders could improve their role in the fight against HIV/AIDS with education and sensitization-specifically aimed at dismantling the myths about HIV transmission, and the stereotyping of susceptible sub-populations, and (2) a consultative dialogue between PWHAs and religious leaders is pivotal to a successful faith-based HIV intervention in Trinidad.…”
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“…BACKGROUND: The epidermal growth factor receptor (EGFR) gene is the prototype member of the type I receptor tyrosine kinase (TK) family and plays a pivotal role in cell proliferation and differentiation. …”
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“…METHODS: Thirty subjects (13 normal knee function, 17 below normal knee function) with an isolated ACLR, who participated in jumping, cutting and pivoting activities ≥ 50 hrs/yr prior to their injury, were included in this study. …”
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“…Subjects were between the ages of 14 and 44 who previously had participated in level I/II pivoting/cutting sports. Subjects underwent isokinetic quadriceps and hamstrings strength assessment at 60 degrees/second (Biodex System III, Shirley, NY) prior to surgery and at 12, and 24 weeks post-operatively. …”
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“…METHODS: Athletes who participated in cutting and pivoting sports before ACLR were tested one year after ACLR; 18 with ST/G (HS) autografts, 5 with bone-patella-tendon-bone (BPTB) autografts, and 12 with allografts (Allo). …”
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“…WIDER IMPLICATIONS OF THE FINDINGS: P plays a pivotal role in endometrial function. P-action is mediated through interaction with the PR. …”
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“…Parental environment and resources are pivotal in children's cognitive development. LIMITATIONS, REASON FOR CAUTION: The sample size of the ART cohort of children is small across each time period (N = 150–180) in comparison with NC children (N = 10 496–11 955). …”
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“…Increasing evidence suggests that inflammation has a pivotal part in its pathogenesis. Interleukin-1β (IL-1β) is a primary mediator of local inflammatory processes in OA. …”
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“…Skeletal muscle and possibly also brown adipose tissue (BAT) are involved in human energy metabolism and nitric oxide (NO) is suggested to play a pivotal role in regulating mitochondrial biogenesis in both tissues. …”
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“…BACKGROUND: The development and utilization of genetic markers play a pivotal role in marker-assisted breeding of rice cultivars during pyramiding of valuable genes. …”
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“…Background: Maternal nutrition is a pivotal factor in determining long-term energy homeostasis in the offspring. …”
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“…Accumulating studies suggest that neuroinflammation characterized by microglial overactivation plays a pivotal role in the pathogenesis of Parkinson’s disease. …”
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“…BACKGROUND: ADAM is an investigational system for intracutaneous drug administration. In a pivotal Phase 2b/3 study (ZOTRIP, N = 321 in the modified intention‐to‐treat population), ADAM zolmitriptan 3.8 mg provided superior pain freedom and freedom from patients’ usual most bothersome associated symptom (MBS), compared with placebo at 2 hours post‐dose. …”
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