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  1. 32801
    “…Compared with those in the pivotal trial, inpatients in our cohort were older (71 ± 12 vs. 61 ± 14 years; P < 0.001); had more frequently Functional Class II (41 [41.0%] vs. 100 [22.7%]; P < 0.001), higher levels of N‐terminal pro‐B type natriuretic peptide (4044 [1630–8680] vs. 2013 [1002–4132] pg/mL; P < 0.001), better glomerular filtration rate (63.5 [51.0–80.0] vs. 58.4 [47.5–71.5] mL/min; P = 0.01), and higher systolic blood pressure (121 [110–136] vs. 118 [110–133] mmHg; P = 0.03); and received angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers more frequently (92 [92.0%] vs. 208 [52.7%]; P < 0.001). …”
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    Safety of sacubitril/valsartan initiated during hospitalization: data from a non‐selected cohort
  2. 32802
    “…METHODS AND FINDINGS: We analyzed data from three trials–RV144 (NCT00223080), HVTN 097 (NCT02109354), and HVTN 100 (NCT02404311), the latter of which was pivotal in advancing the tested pox-protein HIV vaccine regimen to the HVTN 702 Phase 2b/3 efficacy trial. …”
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    Landscapes of binding antibody and T-cell responses to pox-protein HIV vaccines in Thais and South Africans
  3. 32803
    “…Conclusion: Estrogen is pivotal for epiphyseal closure in both sexes. As demonstrated in this case, estrogen deficiency in men results in tall stature and eunuchoid habitus, while it is also associated with low bone density and metabolic syndrome. …”
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    SUN-033 A Rare Case: Bone Pain and Continued Linear Growth in a Young Adult Male Due to Aromatase Deficiency
  4. 32804
    “…BACKGROUND: Despite attempts to predict which clinical high risk (CHR) individuals will convert to schizophrenia (SCZ), current neurocognitive tests have yielded only modest results. Stress plays a pivotal role in the inception of psychotic symptoms. …”
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    S65. THE ‘STRESS-SENSITIVE SELF’ IN PSYCHOSIS: A PILOT STUDY AMONG HEALTHY INDIVIDUALS OF A CHALLENGE (STRESS) TEST OF SELF-RELATED NEUROCOGNITIVE CAPACITIES
  5. 32805
    “…The involvement of maternal antipathy and neglect in the aforementioned association highlights the pivotal role of the mother in the development of the child’s capacity to envision distinct mental states in self and others, a prerequisite for self-awareness and self-other individuation. …”
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    T106. CHILDHOOD TRAUMA IS ASSOCIATED WITH THEORY OF MIND IMPAIRMENT IN SCHIZOPHRENIA-SPECTRUM PSYCHOSIS
  6. 32806
    “…Therefore, early evaluation and monitoring of both liver and kidney functions, as well as hematologic parameters, are pivotal to forecast the progression of COVID-19. OBJECTIVES: In this study, we performed a systematic review and meta-analysis to investigate the association between several complications, including acute kidney injury (AKI), acute liver injury (ALI), and coagulopathy, with poor outcomes in COVID-19. …”
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    Multiorgan Failure With Emphasis on Acute Kidney Injury and Severity of COVID-19: Systematic Review and Meta-Analysis
  7. 32807
    “…In young patients returning to high-risk cutting and pivoting sports, graft rupture is the most feared complication of ACL reconstruction. …”
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    Graft Choice for Adolescent Athletes Returning to High-Risk Sports: A Matched Cohort Analysis of Patellar Tendon and Hamstring Autografts
  8. 32808
    “…The prolog focuses on the way, whereas the section on methanol fuel cells on the how and the post log on what is expected post-COVID-19 era in science and technology as China pivots to a post-fossil fuel economy. China's industrial growth has been through internal market reforms and supplies side economics from the Chinese markets for fossil fuels except for petroleum. …”
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    Electrocatalysts for direct methanol fuel cells to demonstrate China's renewable energy renewable portfolio standards within the framework of the 13th five-year plan
  9. 32809
    “…IMPORTANCE: In the pivotal Bevacizumab-Avastin Adjuvant (AVANT) trial, patients with high-risk stage II colon cancer (CC) had 5-year and 10-year overall survival (OS) rates of 88% and 75%, respectively, with adjuvant fluorouracil and oxaliplatin–based chemotherapy; however, the trial did not demonstrate a disease-free survival (DFS) benefit of adding bevacizumab to oxaliplatin-based chemotherapy in stage III CC and suggested a detrimental effect on OS. …”
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    Association of Bevacizumab Plus Oxaliplatin-Based Chemotherapy With Disease-Free Survival and Overall Survival in Patients With Stage II Colon Cancer: A Secondary Analysis of the AVANT Trial
  10. 32810
    “…METHODS: In the ZOE-50 and ZOE-70 pivotal Phase 3 efficacy studies of RZV, 29,305 participants aged 50–96 received 2 doses of RZV vs. placebo in 1:1 randomization. …”
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    5. How Does Frailty Impact the Efficacy, Reactogenicity, Immunogenicity and Safety of the Adjuvanted Recombinant Zoster Vaccine? A Secondary Analysis of the ZOE-50 and ZOE-70 Studies
  11. 32811
    “…BACKGROUND: Cabotegravir (CAB) and rilpivirine (RPV) are under development as a novel long-acting (LA) regimen for maintenance of HIV virologic suppression. Pooled data from pivotal phase III trials demonstrated noninferiority of CAB + RPV LA given as gluteal intramuscular injections vs current antiretroviral regimen (CAR) on the primary endpoint of HIV-1 ribonucleic acid (RNA) ≥50c/mL at Week 48, with high levels of adherence. …”
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    1029. Long-Term Patient Adherence and Management of Treatment Interruptions With Long-Acting Injectable Cabotegravir + Rilpivirine for Maintenance Therapy in Phase IIb/III Studies
  12. 32812
    “…FOX family protein lays a pivotal role in metabolism. ROS is involved in tumor progression and is associated with the expression of lots of transcription factors. …”
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    FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter
  13. 32813
    “…Residency, the first several years after a college education, is a pivotal time in the development of a qualified doctor. …”
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    The “Plan-Do-Check-Action” Plan Helps Improve the Quality of the “Standardized Training of Resident Physicians”: An Analysis of the Results of the First Pass Rate
  14. 32814
    “…Background: Once-weekly TransCon hGH (lonapegsomatropin) is an investigational long-acting prodrug of somatropin in development for GHD. In the pivotal 52-week phase 3 heiGHt trial, lonapegsomatropin demonstrated superior annualized height velocity (AHV) compared to the same weekly dose of daily somatropin in treatment-naïve children with GHD. …”
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    Efficacy and Safety of up to 2 Years of Treatment With TransCon hGH (Lonapegsomatropin) in Treatment-Naïve and Treatment-Experienced Children With Growth Hormone Deficiency
  15. 32815
    “…Conclusion: This study screened novel biological markers and investigated the differentiated circRNA-miRNA-mutated hub gene axis, which may play a pivotal role in the nosogenesis of PSS and RSS. Some circRNAs may be deemed new diagnostic or therapeutic targets that could be conducive to the future clinical treatment of SS.…”
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    Identification of Potential Genomic Alterations and the circRNA-miRNA-mRNA Regulatory Network in Primary and Recurrent Synovial Sarcomas
  16. 32816
    “…AIMS: Endothelial cell vascular endothelial growth factor receptor 2 (VEGFR‐2) plays a pivotal role in angiogenesis, which induces physiological cardiomyocyte hypertrophy via paracrine signalling between endothelial cells and cardiomyocytes. …”
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    Soluble vascular endothelial growth factor receptor 2 and prognosis in patients with chronic heart failure
  17. 32817
    “…Overexpression of PRKN (parkin RBR E3 ubiquitin protein ligase), which has a pivotal role in mitophagy regulation, suppresses the extracellular mitochondria release under basal and stress condition, whereas its knockdown exacerbates it. …”
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    Alternative mitochondrial quality control mediated by extracellular release
  18. 32818
    “…Our findings provide pivotal epidemiological information and indicate risk factors for IFIs in patients with SLE. …”
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    Epidemiology and risk of invasive fungal infections in systemic lupus erythematosus: a nationwide population-based cohort study
  19. 32819
    “…Registered on September 22, 2016. HVTN 702: Pivotal Phase 2b/3 ALVAC/Bivalent gp120/MF59 HIV Vaccine Prevention Safety and Efficacy Study in South Africa, NCT02968849. …”
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    Participants’ characteristics and motivations to screen for HIV vaccine and monoclonal antibody trials in KwaZulu-Natal, South Africa
  20. 32820
    “…The delayed initiation of both innate and adaptive immunity resulted in elevated SARS-CoV-2 shedding and was a pivotal cause of COVID-19 severity. Spatiotemporally, viral shedding and postviral bacterial infection evoked stronger innate immunity. …”
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    A Multicompartment Mathematical Model Based on Host Immunity for Dissecting COVID-19 Heterogeneity
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