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  1. 32861
    “…These procedures are inconvenient in rural health systems of disease-endemic countries. A pivotal study established fexinidazole as the first oral monotherapy to be effective against non-severe stage 2 g-HAT. …”
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    Oral fexinidazole for stage 1 or early stage 2 African Trypanosoma brucei gambiense trypanosomiasis: a prospective, multicentre, open-label, cohort study
  2. 32862
    “…Given these challenges, the NMDP as well as other donor registries pivoted to providing cryopreserved products. We sought to evaluate the effect of cryopreservation on the infusion of allogeneic products, analyzing all allogeneic products collected from March 17, 2020 through June 30, 2021. …”
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    Neither COVID-19, Nor Cryopreservation, Prevented Allogeneic Product Infusion: A Report from the National Marrow Donor Program
  3. 32863
    “…This information will prove a pivotal role in directing further studies on the function of the LchiWRKY gene family in abiotic stress response and provides a theoretical basis for popularizing afforestation in different regions of China. …”
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    Genome-wide identification of the Liriodendron chinense WRKY gene family and its diverse roles in response to multiple abiotic stress
  4. 32864
    por Cao, Jing, Yuan, Lei
    Publicado 2022
    “…Three differentially expressed pivotal lncRNAs (LA16c-312E8.2, RP5-1160K1.3, and MIR22HG) in the co-expression network may serve as biomarkers and intervention targets for the diagnosis and treatment of HCM.…”
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    Identification of key genes for hypertrophic cardiomyopathy using integrated network analysis of differential lncRNA and gene expression
  5. 32865
    “…Moreover, the harvest of vessels prolongs the surgical procedure and it may lead to the morbidity of donor site in elder patients: therefore, it seems that the use of tissue-engineered vessels would be an attractive and less invasive substitute for autologous vascular grafts. Apelin-13 plays a pivotal role in cell proliferation, survival, and attachment; therefore, covalent attachment of apelin-13 to the acellular scaffolds might be a favorable approach for improving recellularization efficacy. …”
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    An efficient strategy to recellularization of a rat aorta scaffold: an optimized decellularization, detergent removal, and Apelin-13 immobilization
  6. 32866
    por Rabie, Amgad M., Eltayb, Wafa A.
    Publicado 2023
    “…To cut it short, the present pivotal findings of this comprehensive work disclosed the promising repositioning potentials of the three 2-aminothiadiazoles, CoViTris2022, Taroxaz-26, and ChloViD2022, to successfully interfere with the crucial biological interactions of the coronaviral-2 polymerase/exoribonuclease with the four principal RNA nucleotides, and, as a result, cure COVID-19 infection, encouraging us to rapidly start the three drugs’ broad preclinical/clinical anti-COVID-19 evaluations. …”
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    Potent Dual Polymerase/Exonuclease Inhibitory Activities of Antioxidant Aminothiadiazoles Against the COVID-19 Omicron Virus: A Promising In Silico/In Vitro Repositioning Research Study
  7. 32867
    “…METHODS: Fifty-four participants between the ages of 10 and 25 years and within 5 to 15 months of ACL reconstruction who were planning to return to at least 50 hours per year of cutting and pivoting activities were included. Patients with a previous history of surgery to either knee or concomitant posterior cruciate ligament reconstruction were excluded from the study. …”
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    Poster 323: Factors Impacting Return to Sport Timing Following ACL Reconstruction
  8. 32868
    “…Given the increasing use of ART to alleviate infertility in women of AMA, it is pivotal to develop ART–AMA models addressing the effects of maternal aging on offspring health. …”
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    Advanced maternal age causes adverse programming of mouse blastocysts leading to altered growth and impaired cardiometabolic health in post-natal life
  9. 32869
    por Ali, Saadia Sasha, Mahto, Arti
    Publicado 2020
    “…Empathy, effective communication, and multi-disciplinary team working remain pivotal to our speciality.…”
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    EP34 Ovarian cancer presenting as primary Sjögren’s syndrome: a rare but important mimic
  10. 32870
    “…Preclinical studies have demonstrated that NK cells play a pivotal role in reducing IAV-induced pulmonary infection; however, little is known about the therapeutic potential of adoptively transferred NK cells for IAV infections. …”
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    Human Placental Hematopoietic Stem Cell Derived Natural Killer Cells (CYNK-001) Mediate Protection Against Influenza A Viral Infection
  11. 32871
    “…Here, a consolidated, complete immune reconstitution in allogeneic HSCT recipients, as well as age and a still active disease in the autologous setting, could have played opposite pivotal roles. [Figure: see text] DISCLOSURES: Delia:  Gilead: Consultancy; Amgen: Consultancy; abbvie: Consultancy; Jazz pharmaceuticals: Consultancy.…”
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    Serological Response Following BNT162b2 Anti-Sars-Cov-2 mRNA Vaccination in Hematopoietic Stem Cell Transplantation Patients
  12. 32872
    “…CASE REPORT - DISCUSSION: We report the challenges in diagnosing a mimicker of JIA, where awareness of the rare syndrome and high index of suspicion plays a pivotal role in the diagnosis of the condition, especially in the absence of genetic testing due to resource-poor settings. …”
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    O18 When joints vanish
  13. 32873
    “…METHODS: 25 healthy females (age 13.8 ± 1.4 years, mass 52.4 ± 9.3 kg, height 161.7 ± 6.0 cm) who regularly participated in cutting or pivoting sports were included. A repeated measures study design was used. …”
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    The Reliability of Two Dimensional Kinematic Assessment of a 45-Degree Side Step Cut
  14. 32874
    “…In bioinformatic analysis, we identified EGFR, HSP90AA1, APP, TP53, PTEN, UBC, FN1, ELAVL1 and CALM1 as regulatory genes which could play a pivotal role in COVID-19 related thrombosis. We also found miR-16-5p, miR-27a-3p, let-7b-5p and miR-155-5p as regulators in the coagulation and thrombosis process. …”
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    Thrombosis-related circulating miR-16-5p is associated with disease severity in patients hospitalised for COVID-19
  15. 32875
    “…Sites with more recovery could indicate successful strategies to mitigate service interruption, such as pivoting to telehealth approaches for evaluation. PUBLIC HEALTH ACTION: From 2016 through February of 2020, ASD evaluation and identification among the cohort of children aged 4 years was outpacing ASD evaluation and identification 4 years earlier (from 2012 until March 2016) among the cohort of children aged 8 years in 2020 . …”
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    Early Identification of Autism Spectrum Disorder Among Children Aged 4 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2020
  16. 32876
    “…Studies were graded with the highest level of evidence (1++), if they met the criteria of European Medicines Agency (EMA)-Guidance: Points to consider on applications with 1. meta-analyses; 2. one pivotal study. Results: For the medical section, the age of the study participants ranges from 6 months to 17 years. …”
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    Vaccination of children with a live-attenuated, intranasal influenza vaccine – analysis and evaluation through a Health Technology Assessment
  17. 32877
    por Ghuman, Hira, Samaranayaka, Muditha
    Publicado 2019
    “…In atypical presentations, with limited feasibility for histological studies, radiological imaging of arterial morphology has proven pivotal in reaching a diagnosis of LVV. A key finding for GCA on ultrasound is the ‘halo’ sign’. …”
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    49. Giant cell arteritis and Takayasu arteritis: two sides of the same coin in an elderly female?
  18. 32878
    “…Given the lack of preventative or therapeutic agents and the emerging evidence of the pivotal protective role of SARS-CoV-2-specific CD4+ and CD8+ T cells, we sought to explore the feasibility of developing a banked, SARS-CoV-2-specific VST product to treat those at highest risk of severe COVID-19 disease (i.e. …”
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    Using Allogeneic, Off-the-Shelf, Sars-Cov-2-Specific T Cells to Treat High Risk Patients with COVID-19
  19. 32879
    “…All too often GPs are not given enough credit for the pivotal role they play in unifying the care a patient may receive from specialties that may otherwise work independently of one another. …”
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    P31 Cogan's syndrome—a neglected autoimmune vasculitis
  20. 32880
    “…This has fostered an atmosphere of success among young physician-scientists and is one of the reasons that we endorse recommendation #9 from the PSWR, suggesting that Clinical and Translational Science Award (CTSA) Institutes play pivotal roles in monitoring and enhancing the success of the physician-scientist workforce. …”
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    2237 From bedside to benchmarks: A physician-scientist workforce dashboard for biomedical research institutions
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