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  1. 661
    “…2013 marks a milestone year for plasmid DNA vaccine development as a first-in-class cytomegalovirus (CMV) DNA vaccine enters pivotal phase 3 testing. This vaccine consists of two plasmids expressing CMV antigens glycoprotein B (gB) and phosphoprotein 65 (pp65) formulated with a CRL1005 poloxamer and benzalkonium chloride (BAK) delivery system designed to enhance plasmid expression. …”
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    Clinical Development of a Cytomegalovirus DNA Vaccine: From Product Concept to Pivotal Phase 3 Trial
  2. 662
    “…The top disease associations included cancers and diseases and disorders of the nervous system, with Schizophrenia, HD, and pancreatic ductal carcinoma among the top five, suggesting that aberrant palmitoylation may play a pivotal role in the balance of cell death and survival. …”
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    Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers
  3. 663
    “…In the present study, we analyzed microRNA (miRNA) and gene expression profiles using 499 papillary thyroid carcinoma (PTC) samples and 58 normal thyroid tissues obtained from The Cancer Genome Atlas database. A pivotal regulatory network of 18 miRNA and 16 targets was identified. …”
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    Expression profiles of pivotal microRNAs and targets in thyroid papillary carcinoma: an analysis of The Cancer Genome Atlas
  4. 664
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    Proteomics identifies Bacillus cereus EntD as a pivotal protein for the production of numerous virulence factors
  5. 665
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    NMFBFS: A NMF-Based Feature Selection Method in Identifying Pivotal Clinical Symptoms of Hepatocellular Carcinoma
  6. 666
    por Homedes, Núria, Ugalde, Antonio
    Publicado 2015
    “…FDA medical reviews indicated the countries where pivotal clinical trials had been conducted. The registration status of the products was obtained from pharmaceutical registers; pharmaceutical companies confirmed their availability in national markets and local pricing observatories provided the price of medicines in retail pharmacies. …”
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    Availability and affordability of new medicines in Latin American countries where pivotal clinical trials were conducted
  7. 667
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    Bilaterally enlarged parotids and sicca symptoms as a presentation of sarcoidosis: Pivotal role of aspiration cytology in diagnosis
  8. 668
    “…RESULTS: A single mutation of large effect (S117N) serves as a pivot point for evolution to high resistance regions of the landscape. …”
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    A pivot mutation impedes reverse evolution across an adaptive landscape for drug resistance in Plasmodium vivax
  9. 669
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    Emphasizing the pivotal role of fine-needle aspiration cytology in a case of recurrent malignant chondroid syringoma
  10. 670
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    Corrigendum: Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I
  11. 671
    “…The addition of adjuvant trastuzumab therapy for 1 year to standard chemotherapy significantly improved disease-free survival and overall survival versus chemotherapy alone in a number of pivotal early breast cancer studies. Here we review long-term follow-up data on the efficacy, cardiac safety, and general safety of trastuzumab in these pivotal studies. …”
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    Long-term Follow-up Data from Pivotal Studies of Adjuvant Trastuzumab in Early Breast Cancer
  12. 672
    “…A., Clarke, K. On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.…”
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    On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury
  13. 673
    “…This study unambiguously uses triplex DNA forming as the pivot to integrate nucleic acid amplification and DNAzymes for producing a highly sensitive signal with low background.…”
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    Ultrasensitive colorimetric detection of circulating tumor DNA using hybridization chain reaction and the pivot of triplex DNA
  14. 674
    por Golish, S. Raymond
    Publicado 2017
    “…BACKGROUND: The United States Food and Drug Administration (FDA) reviews class III orthopedic devices submitted for premarket approval with pivotal clinical trials. The purpose of this study was to determine the types of orthopedic devices reviewed, the design of their pivotal clinical trials, and the subjective factors affecting the interpretation of clinical trial data. …”
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    Pivotal trials of orthopedic surgical devices in the United States: predominance of two-arm non-inferiority designs
  15. 675
    “…The data report details the baseline characteristics and observed outcomes among patients included in a large US administrative claims database (Optum Labs Data Warehouse) and those enrolled in the pivotal phase III clinical trials examining apixaban, dabigratan, edoxaban and rivaroxaban versus warfarin for the prevention of cardio embolism (Granger et al., 2011; Cannolly et al., 2009; Patel et al., 2011; Giugliano et al., 2013) [1], [2], [3], [4]. …”
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    Baseline characteristics and event rates among anticoagulated patients with atrial fibrillation in practice and pivotal NOAC trials
  16. 676
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    Elimination of the Pivot-Shift Sign After Repair of an Occult Anterolateral Ligament Injury in an ACL-Deficient Knee
  17. 677
    por Schmid, Otmar, Cassee, Flemming R.
    Publicado 2017
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    On the pivotal role of dose for particle toxicology and risk assessment: exposure is a poor surrogate for delivered dose
  18. 678
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    Pivotal role of Acitretin nanovesicular gel for effective treatment of psoriasis: ex vivo–in vivo evaluation study
  19. 679
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    mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development
  20. 680
    “…PATIENTS AND METHODS: This is a study of a subset of patients recruited into a prospective randomised study of a single radius design versus a medial pivot design, with a minimum follow-up of one year. …”
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    A functional comparison of medial pivot and condylar knee designs based on patient outcomes and parameters of gait
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