Production of IFN-α by Natural IFN-α Producing Cells (NIPC), induced by apoptotic cells and autoantibodies via FcγRII, could be a pivotal event in the etiopathogenesis of SLE

por Rönnblom, LR, Lövgren, T, Bsve, U, Alm, GV
Publicado 2002

Comment on: Gorboulev et al. Na(+)-D-glucose Cotransporter SGLT1 Is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion....

por Kellett, George L.
Publicado 2012

Learning from a cluster randomized controlled trial to improve healthcare workers’ access to prevention and care for tuberculosis and HIV in Free State, South Africa: the pivotal role of information systems

por Yassi, Annalee, Adu, Prince A., Nophale, Letshego, Zungu, Muzimkhulu
Publicado 2016

Bone marrow-derived macrophages distinct from tissue-resident macrophages play a pivotal role in Concanavalin A-induced murine liver injury via CCR9 axis

por Amiya, Takeru, Nakamoto, Nobuhiro, Chu, Po-sung, Teratani, Toshiaki, Nakajima, Hideaki, Fukuchi, Yumi, Taniki, Nobuhito, Yamaguchi, Akihiro, Shiba, Shunsuke, Miyake, Rei, Katayama, Tadashi, Ebinuma, Hirotoshi, Kanai, Takanori
Publicado 2016

Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades

por Adamiak, M, Abdelbaset-Ismail, A, Suszynska, M, Abdel-Latif, A, Ratajczak, J, Ratajczak, M Z
Publicado 2017

Dendritic cells, macrophages, NK and CD8(+) T lymphocytes play pivotal roles in controlling HSV-1 in the trigeminal ganglia by producing IL1-beta, iNOS and granzyme B

por Lucinda, Natália, Figueiredo, Maria Marta, Pessoa, Natália Lima, Santos, Beatriz Senra Álvares da Silva, Lima, Graciela Kunrath, Freitas, Arthur Molinari, Machado, Alexandre Magalhães Vieira, Kroon, Erna Geessien, Antonelli, Lis Ribeiro do Valle, Campos, Marco Antônio
Publicado 2017

Pooled efficacy and safety of eslicarbazepine acetate as add‐on treatment in patients with focal‐onset seizures: Data from four double‐blind placebo‐controlled pivotal phase III clinical studies

por Elger, Christian, Koepp, Mathias, Trinka, Eugen, Villanueva, Vicente, Chaves, João, Ben‐Menachen, Elinor, Kowacs, Pedro A., Gil‐Nagel, António, Moreira, Joana, Gama, Helena, Rocha, José‐Francisco, Soares‐da‐Silva, Patrício
Publicado 2017

OsCER1 Plays a Pivotal Role in Very-Long-Chain Alkane Biosynthesis and Affects Plastid Development and Programmed Cell Death of Tapetum in Rice (Oryza sativa L.)

por Ni, Erdong, Zhou, Lingyan, Li, Jing, Jiang, Dagang, Wang, Zhonghua, Zheng, Shaoyan, Qi, Hua, Zhou, Ying, Wang, Cimei, Xiao, Shi, Liu, Zhenlan, Zhou, Hai, Zhuang, Chuxiong
Publicado 2018

Riboflavin Plays a Pivotal Role in the UVA-Induced Cytotoxicity of Fibroblasts as a Key Molecule in the Production of H(2)O(2) by UVA Radiation in Collaboration with Amino Acids and Vitamins

por Yoshimoto, Satoshi, Kohara, Nana, Sato, Natsu, Ando, Hideya, Ichihashi, Masamitsu
Publicado 2020

Population Pharmacokinetic and Exposure–Response Analysis of Finerenone: Insights Based on Phase IIb Data and Simulations to Support Dose Selection for Pivotal Trials in Type 2 Diabetes with Chronic Kidney Disease

por Snelder, Nelleke, Heinig, Roland, Drenth, Henk-Jan, Joseph, Amer, Kolkhof, Peter, Lippert, Jörg, Garmann, Dirk, Ploeger, Bart, Eissing, Thomas
Publicado 2019

LreEF1A4, a Translation Elongation Factor from Lilium regale, Is Pivotal for Cucumber Mosaic Virus and Tobacco Rattle Virus Infections and Tolerance to Salt and Drought

por Sun, Daoyang, Ji, Xiaotong, Jia, Yong, Huo, Dan, Si, Shiying, Zeng, Lingling, Zhang, Yanlong, Niu, Lixin
Publicado 2020

Activation of LKB1 rescues 3T3-L1 adipocytes from senescence induced by Sirt1 knock-down: a pivotal role of LKB1 in cellular aging

por Lan, Fan, Lin, Yan, Gao, Zhenfeng, Cacicedo, Jose M., Weikel, Karen, Ido, Yasuo
Publicado 2020

The Pivotal Role of Viruses in the Pathogeny of Chronic Lymphocytic Leukemia: Monoclonal (Type 1) IgG K Cryoglobulinemia and Chronic Lymphocytic Leukemia Diagnosis in the Course of a Human Metapneumovirus Infection

por Barben, Jérémy, Putot, Alain, Mihai, Anca-Maria, Vovelle, Jérémie, Manckoundia, Patrick
Publicado 2021

Association of Ligamentous Laxity, Male Sex, Chronicity, Meniscal Injury, and Posterior Tibial Slope With a High-Grade Preoperative Pivot Shift: A Post Hoc Analysis of the STABILITY Study

por Batty, Lachlan M., Firth, Andrew, Moatshe, Gilbert, Bryant, Dianne M., Heard, Mark, McCormack, Robert G., Rezansoff, Alex, Peterson, Devin C., Bardana, Davide, MacDonald, Peter B., Verdonk, Peter C.M., Spalding, Tim, Getgood, Alan M.J., Willits, Kevin, Birmingham, Trevor, Hewison, Chris, Wanlin, Stacey, Firth, Andrew, Pinto, Ryan, Martindale, Ashley, O’Neill, Lindsey, Jennings, Morgan, Daniluk, Michal, Boyer, Dory, Zomar, Mauri, Moon, Karyn, Pritchett, Raely, Payne, Krystan, Fan, Brenda, Mohan, Bindu, Buchko, Gregory M., Hiemstra, Laurie A., Kerslake, Sarah, Tynedal, Jeremy, Stranges, Greg, Mcrae, Sheila, Gullett, LeeAnne, Brown, Holly, Legary, Alexandra, Longo, Alison, Christian, Mat, Ferguson, Celeste, Mohtadi, Nick, Barber, Rhamona, Chan, Denise, Campbell, Caitlin, Garven, Alexandra, Pulsifer, Karen, Mayer, Michelle, Simunovic, Nicole, Duong, Andrew, Robinson, David, Levy, David, Skelly, Matt, Shanmugaraj, Ajaykumar, Howells, Fiona, Tough, Murray, Thompson, Pete, Metcalfe, Andrew, Asplin, Laura, Dube, Alisen, Clarkson, Louise, Brown, Jaclyn, Bolsover, Alison, Bradshaw, Carolyn, Belgrove, Larissa, Millan, Francis, Turner, Sylvia, Verdugo, Sarah, Lowe, Janet, Dunne, Debra, McGowan, Kerri, Suddens, Charlie-Marie, Declercq, Geert, Vuylsteke, Kristien, Van Haver, Mieke
Publicado 2021

Quantifying the heterogeneity of cognitive functioning in Alzheimer’s disease to extend the placebo-treatment dichotomy: Latent class analysis of individual-participant data from five pivotal randomized clinical trials of donepezil

por Levine, Stephen Z., Goldberg, Yair, Yoshida, Kazufumi, Samara, Myrto, Cipriani, Andrea, Iwatsubo, Takeshi, Leucht, Stefan, Furawaka, Toshiaki A.
Publicado 2021

Functional glycomics and evidence for gain- and loss-of-functions of target proteins for glycosyltransferases involved in N-glycan biosynthesis: their pivotal roles in growth and development, cancer metastasis and antibody therapy against cancer

por Taniguchi, Naoyuki, Gu, Jianguo, Takahashi, Motoko, Miyoshi, Eiji
Publicado 2004

MALAT1: A Pivotal lncRNA in the Phenotypic Switch of Gastric Smooth Muscle Cells via the Targeting of the miR-449a/DLL1 Axis in Diabetic Gastroparesis

por Wang, Yanjuan, Wang, Yan, Zhu, Boqian, Zhu, Ying, Jiang, Ya, Xiong, Wenjie, Lin, Lin, Gong, Yaoyao
Publicado 2021

Restoration of Sarco/Endoplasmic Reticulum Ca(2+)-ATPase Activity Functions as a Pivotal Therapeutic Target of Anti-Glutamate-Induced Excitotoxicity to Attenuate Endoplasmic Reticulum Ca(2+) Depletion

por Zhang, Wen, Ye, Fanghua, Pang, Nan, Kessi, Miriam, Xiong, Juan, Chen, Shimeng, Peng, Jing, Yang, Li, Yin, Fei
Publicado 2022

Pain, balance, and mobility in people 1 year after total knee arthroplasty: a non-randomized cross-sectional pilot study contrasting posterior-stabilized and medial-pivot designs

por Lo, Cathy W. T., Brodie, Matthew A., Tsang, William W. N., Lord, Stephen R., Yan, Chun-Hoi, Wong, Arnold Y. L.
Publicado 2022

PB2196: EQUATOR: A PIVOTAL PHASE 3 DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED STUDY OF ITOLIZUMAB IN COMBINATION WITH CORTICOSTEROIDS FOR THE INITIAL TREATMENT OF ACUTE GRAFT-VERSUS-HOST DISEASE

por Koreth, J., Kean, L., Chinn, L., Acevedo, L. M., Bandman, O., Rothman, J., Connelly, S., Thomas, D., Cutler, C.
Publicado 2022