Biologic Drug Quality Assurance to Optimize HER2 + Breast Cancer Treatment: Insights from Development of the Trastuzumab Biosimilar SB3

por Lüftner, Diana, Lyman, Gary H., Gonçalves, João, Pivot, Xavier, Seo, Minji
Publicado 2020

S262: SAFETY AND EFFICACY OF OBECABTAGENE AUTOLEUCEL (OBE-CEL), A FAST-OFF RATE CD19 CAR IN RELAPSED/REFRACTORY ADULT B-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA:TOP LINE RESULTS OF THE PIVOTAL FELIX STUDY

por Roddie, Claire, Sandhu, Karamjeet, Tholouli, Eleni, Shaughnessy, Paul, Barba Suñol, Pere, Nuno Direito de Morais Guerreiro, Manuel, Abedi, Mehrdad, Bishop, Michael, Yared, Jean, Ghobadi, Armin, Yallop, Deborah, Logan, Aaron, Amer, Beitinjaneh, Pantin, Jeremy, Arellano, Martha L, Chaganti, Sridhar, Malladi, Ram, Menne, Tobias, Escamilla, Virginia, Hodby, Katharine, Gundabolu, Krishna, Mountjoy, Luke, Odwyer, Kristen, Abedin, Sameem, Alkhateeb, Hassan, Shah, Bijal, Basilico, Silvia, Cluxton, Deborah, Dawes, Joanna, Lao-Sirieix, Pierre, Raymond, Meera, Shang, Justin, Hu, Yanqing, Pittari, Gianfranco, Saxena, Kapil, Brugger, Wolfram, Zhang, Y, Pule, Martin, Park, Daniel, De Angelo, Daniel, Jabbour, Elias
Publicado 2023

OR25-07 A Multi-Center, Open-Label, Pivotal Phase 2 Study of Azedra® (HSA I-131-MIBG) in Patients with Unresectable, Locally Advanced or Metastatic Pheochromocytoma or Paraganglioma: Updated Long-Term Survival and Safety

por Jimenez, Camilo, Chin, Bennett B, Noto, Richard B, Dillon, Joseph Stephen, Solnes, Lilja B, DiPippo, Vincent A, Stambler, Nancy, Wong, Vivien, Pryma, Daniel A
Publicado 2020

Effect of anti–tumor necrosis factor therapy on the risk of respiratory tract infections and related symptoms in patients with psoriasis—A meta-estimate of pivotal phase 3 trials relevant to decision making during the COVID-19 pandemic

por Syed, Maha N., Shah, Mohsin, Shin, Daniel B., Wan, Marilyn T., Winthrop, Kevin L., Gelfand, Joel M.
Publicado 2021

LBA16 IMpassion130: Final OS analysis from the pivotal phase III study of atezolizumab + nab-paclitaxel vs placebo + nab-paclitaxel in previously untreated locally advanced or metastatic triple-negative breast cancer

por Emens, L.A., Adams, S., Barrios, C.H., Dieras, V.C., Iwata, H., Loi, S., Rugo, H.S., Schneeweiss, A., Winer, E.P., Patel, S., Henschel, V., Swat, A., Kaul, M., Molinero, L., Chui, S.Y., Schmid, P.
Publicado 2020

Pooled analyses of eribulin in metastatic breast cancer patients with at least one prior chemotherapy

por Pivot, X., Marmé, F., Koenigsberg, R., Guo, M., Berrak, E., Wolfer, A.
Publicado 2016

Evaluating the clinical effectiveness and safety of various HER2-targeted regimens after prior taxane/trastuzumab in patients with previously treated, unresectable, or metastatic H...

por Paracha, Noman, Reyes, Adriana, Diéras, Véronique, Krop, Ian, Pivot, Xavier, Urruticoechea, Ander
Publicado 2020

Pivotal role of human stearoyl-CoA desaturases (SCD1 and 5) in breast cancer progression: oleic acid-based effect of SCD1 on cell migration and a novel pro-cell survival role for SCD5

por Angelucci, Cristiana, D'Alessio, Alessio, Iacopino, Fortunata, Proietti, Gabriella, Di Leone, Alba, Masetti, Riccardo, Sica, Gigliola
Publicado 2018

Biochemical Tumor Marker Status and Its Role in Treatment Response in Patients Who Received High-Specific-Activity I-131 MIBG in Advanced Pheochromocytoma and Paraganglioma (PPGL): Results From a Pivotal Phase 2 Clinical Trial

por Jimenez, Camilo, Chin, Bennett B, Noto, Richard A, Noto, Richard B, Dillon, Joseph S, Solnes, Lilja, DiPippo, Vincent A, Stambler, Nancy, Pryma, Daniel A
Publicado 2021

Promouvoir la vaccination au sein des populations à risque : l’équipe pharmaceutique hospitalière s’implique !

por Laloi, L., Delmas, M., Morfin, F., Pivot, C., Paillet, C., Janoly Dumenil, A.
Publicado 2022

The TIR-domain-containing adapter inducing interferon-β-dependent signaling cascade plays a crucial role in ischemia–reperfusion-induced retinal injury, whereas the contribution of the myeloid differentiation primary response 88-dependent signaling cascade is not as pivotal

por Dvoriantchikova, Galina, Santos, Andrea Rachelle C, Danek, Dagmara, Dvoriantchikova, Xenia, Ivanov, Dmitry
Publicado 2014

An mRNA-specific tRNA(i) carrier eIF2A plays a pivotal role in cell proliferation under stress conditions: stress-resistant translation of c-Src mRNA is mediated by eIF2A

por Kwon, Oh Sung, An, Sihyeon, Kim, Eunah, Yu, Jinbae, Hong, Ka Young, Lee, Jae Seung, Jang, Sung Key
Publicado 2017

SAT-100 Trial-in-Progress: ZEPHYR, a Pivotal Phase 2b/3 Randomized, Placebo-Controlled Study of Livoletide, a Novel Unacylated Ghrelin Analog, for the Treatment of Hyperphagia and Food-Related Behaviors in Patients with Prader-Willi Syndrome

por Allas, Soraya, Mohideen, Pharis, Delale, Thomas, Lin, Vivian, Tremel, Nadege, Yeh, Michael, Tauber, Maithe
Publicado 2019

Neuroprotective Effect of Mesenchymal Stromal Cell-Derived Extracellular Vesicles Against Cerebral Ischemia-Reperfusion-Induced Neural Functional Injury: A Pivotal Role for AMPK and JAK2/STAT3/NF-κB Signaling Pathway Modulation

por Han, Min, Cao, Ying, Xue, Hao, Chu, Xili, Li, Tingting, Xin, Danqing, Yuan, Lin, Ke, Hongfei, Li, Gang, Wang, Zhen
Publicado 2020

Study protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with sepsis-associated acute kidney injury

por Pickkers, Peter, Angus, Derek C, Arend, Jacques, Bellomo, Rinaldo, van den Berg, Erik, Bernholz, Juliane, Bestle, Morten, Broglio, Kristine, Carlsen, Jan, Doig, Christopher J, Ferrer, Ricard, Joannidis, Michael, Francois, Bruno, Doi, Kent, Kellum, John A, Laterre, Pierre-François, Liu, Kathleen, Mehta, Ravindra L, Murray, Patrick T, Ostermann, Marlies, Pettilä, Ville, Richards, Sharon, Young, Paul, Zarbock, Alexander, Kjølbye, Anne Louise
Publicado 2023

MAINTENANCE HORMONAL TREATMENT IMPROVES PROGRESSION FREE SURVIVAL AFTER A FIRST LINE CHEMOTHERAPY IN PATIENTS WITH METASTATIC BREAST CANCER

por Dufresne, Armelle, Pivot, Xavier, Tournigand, Christophe, Facchini, Thomas, Alweeg, Thierry, Chaigneau, Loic, De Gramont, Aimery
Publicado 2008

Organizing medical oncology care at a regional level and its subsequent impact on the quality of early breast cancer management: a before-after study

por Voidey, Aline, Pivot, Xavier, Woronoff, Anne-Sophie, Nallet, Gilles, Cals, Laurent, Schwetterle, Francis, Limat, Samuel
Publicado 2014

A time and motion study of subcutaneous versus intravenous trastuzumab in patients with HER2‐positive early breast cancer

por De Cock, Erwin, Pivot, Xavier, Hauser, Nik, Verma, Sunil, Kritikou, Persefoni, Millar, Douglas, Knoop, Ann
Publicado 2016

Ring‐Expanded N‐Heterocyclic Carbenes for Copper‐Mediated Azide–Alkyne Click Cycloaddition Reactions

por Sebest, Filip, Dunsford, Jay J., Adams, Matthew, Pivot, Jeremy, Newman, Paul D., Díez‐González, Silvia
Publicado 2018

Rationale and design of two randomized sham-controlled trials of catheter-based renal denervation in subjects with uncontrolled hypertension in the absence (SPYRAL HTN-OFF MED Pivotal) and presence (SPYRAL HTN-ON MED Expansion) of antihypertensive medications: a novel approach using Bayesian design

por Böhm, Michael, Townsend, Raymond R., Kario, Kazuomi, Kandzari, David, Mahfoud, Felix, Weber, Michael A., Schmieder, Roland E., Tsioufis, Konstantinos, Hickey, Graeme L., Fahy, Martin, DeBruin, Vanessa, Brar, Sandeep, Pocock, Stuart
Publicado 2020