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  1. 1481
    “…All VM formulations contained PADRE and CpG as adjuvants and ISA51 as the hydrophobic component of the water-in-oil emulsion. …”
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    Rejection of large HPV-16 expressing tumors in aged mice by a single immunization of VacciMax(® )encapsulated CTL/T helper peptides
  2. 1482
    “…METHODS/PRINCIPAL FINDINGS: We have constructed two structural analogues of HER-2 glyco-lipopeptide (HER-GLP) by synthesizing a chimeric peptide made of one universal CD4(+) epitope (PADRE) and one HER-2 CD8(+) T-cell epitope (HER(420–429)). …”
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    Linear and Branched Glyco-Lipopeptide Vaccines Follow Distinct Cross-Presentation Pathways and Generate Different Magnitudes of Antitumor Immunity
  3. 1483
    “…METHODOLOGY/PRINCIPAL FINDINGS: To establish the basis for a SAPN-based vaccine, B- and CD8(+) T-cell epitopes from the P. falciparum circumsporozoite protein (PfCSP) and the universal CD4 T-helper epitope PADRE were engineered into a versatile small protein (∼125 amino acids) that self-assembles into a spherical nanoparticle repetitively displaying the selected epitopes. …”
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    Protective Antibody and CD8(+) T-Cell Responses to the Plasmodium falciparum Circumsporozoite Protein Induced by a Nanoparticle Vaccine
  4. 1484
    “…Most infestations were reported in the districts of Dom José (36.2%), Padre Palhano (24.7%), and Alto do Cristo (10.6%). …”
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    Community-Based Entomological Surveillance Reveals Urban Foci of Chagas Disease Vectors in Sobral, State of Ceará, Northeastern Brazil
  5. 1485
    “…Turtles were outfitted with satellite transmitters after nesting at Padre Island National Seashore, Texas, USA, from 1998 through 2013 (n = 60); Rancho Nuevo, Tamaulipas, Mexico, during 2010 and 2011 (n = 11); and Tecolutla, Veracruz, Mexico, during 2012 and 2013 (n = 11). …”
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    Inter-nesting movements and habitat-use of adult female Kemp’s ridley turtles in the Gulf of Mexico
  6. 1486
    “…Given the involvement of DNA methylation in the development of lymphocytes, tumorigenicity and tumor progression, we aimed to analyze pre-vaccination DNA methylation profiles of peripheral blood mononuclear cells (PBMCs) from breast cancer subjects vaccinated with a novel peptide-based vaccine referred to as P10s-PADRE. This pilot study was performed to evaluate whether signatures of differentially methylated (DM) loci can be developed as potential predictive biomarkers for prescreening subjects with cancer who will most likely generate an immune response to the vaccine. …”
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    Association of DNA-Methylation Profiles With Immune Responses Elicited in Breast Cancer Patients Immunized With a Carbohydrate-Mimicking Peptide: A Pilot Study
  7. 1487
    “…METHODS: Herein, we designed and synthesized Hantaan virus (HTNV) linear multi-epitope peptide consisting of HLA-A*02-restricted HTNV cytotoxic T cell (CTL) epitope and pan HLA-DR-binding epitope (PADRE), and evaluated the immunogenicity, as well as effectiveness, of multi-epitope peptides in HLA-A2.1/K(b) transgenic mice with interferon (IFN)-γ enzyme-linked immunospot assay, cytotoxic mediator detection, proliferation assay and HTNV-challenge test. …”
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    Protective CD8(+) T-cell response against Hantaan virus infection induced by immunization with designed linear multi-epitope peptides in HLA-A2.1/K(b) transgenic mice
  8. 1488
    “…Recently, we developed a recombinant COVID-19 vaccine (V-01) containing fusion protein (IFN-PADRE-RBD-Fc dimer) as antigen verified to induce protective immunity against SARS-CoV-2 challenge in pre-clinical study, which supported progression to Phase I clinical trials in humans. …”
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    Safety and immunogenicity of a recombinant interferon-armed RBD dimer vaccine (V-01) for COVID-19 in healthy adults: a randomized, double-blind, placebo-controlled, Phase I trial
  9. 1489
    “…Five B-cells and six cytotoxic T-lymphocytes (CTL) epitopes were mapped and finalized from G1 and G2 and were fused with suitable linkers (EAAAK, GGGS, AAY, and GPGPG), a PADRE sequence (13 aa), and an adjuvant (50S ribosomal protein L7/L12) to formulate a chimeric vaccine construct. …”
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    An Immunoinformatics Approach to Design a Potent Multi-Epitope Vaccine against Asia-1 Genotype of Crimean–Congo Haemorrhagic Fever Virus Using the Structural Glycoproteins as a Target
  10. 1490
    Publicado 1966
    Tabla de Contenidos: “…Eclesiastés. -- Sabiduría de los Padres. -- Cien parabolas y apologos del Talmud.…”
    Libro
    Sabiduría de Israel ; tres obras de la cultura judía
  11. 1491
    por Martínez Assad, Carlos R.
    Publicado 2010
    Tabla de Contenidos: “…Entre la ficción y la realidad. El padre Macario. Borrar el pasado -- X. La nueva era. …”
    Libro
    Tabasco : historia breve
  12. 1492
    Tabla de Contenidos: “…Arquitectura y servicio -- El "programa" arquitectónico -- El concepto (de nuevo) -- El padre y la madre -- El "genius locci" -- La inspiración y el trabajo -- El buen ocio -- La "asociación libre" -- Tercera sesión. …”
    Libro
    Arquitectura : pensamiento y creación /
  13. 1493
    “…The E7 peptide but not control peptide (PADRE) induced up-regulation of NFKB1A gene only in HLA-A2 positive iDCs and not in HLA-A2 negative iDCs. …”
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    Molecular Characterization of Antigen-Peptide Pulsed Dendritic Cells: Immature Dendritic Cells Develop a Distinct Molecular Profile when Pulsed with Antigen Peptide
  14. 1494
    “…Also, a CD4 + T-helper epitope, PADRE, was used at the C-terminal of the vaccine by GPGPG and A(EAAAK)2A linkers to form the final vaccine construct. …”
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    Exploring the out of sight antigens of SARS-CoV-2 to design a candidate multi-epitope vaccine by utilizing immunoinformatics approaches
  15. 1495
    “…B cell and T cell epitopes were predicted in silico and mapped with linkers to avoid junctional immunogenicity and to ensure the efficient presentation of exposed epitopes through HLA. β-defensin and PADRE were adjusted at the N-terminal end of the final vaccine as adjuvants. …”
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    An immunoinformatics approach for the design of a multi-epitope vaccine targeting super antigen TSST-1 of Staphylococcus aureus
  16. 1496
    “…The selected peptides were used to design 4 multi-epitope vaccines constructs (SMV1, SMV2, SMV3 and SMV4) with immune-modulating adjuvants, PADRE sequence, and linkers. Peptide cleavage analysis showed that antigen vaccines are processed and presented via of MHC class molecule. …”
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    A Systematic Immuno-Informatic Approach to Design a Multiepitope-Based Vaccine Against Emerging Multiple Drug Resistant Serratia marcescens
  17. 1497
    “…These were subsequently paired with RS09 and flagellin adjuvants, as well as a pan HLA DR-binding epitope (PADRE) sequence to create a vaccine candidate that elicited both cell-mediated and humoral immune responses. …”
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    Design of a multi-epitope vaccine against the pathogenic fungi Candida tropicalis using an in silico approach
  18. 1498
    “…The finalized epitopes were merged with the aid of suitable linkers, an adjuvant (Resuscitation-promoting factor), a PADRE sequence (13 aa), and an HIV TAT sequence (11 aa) to formulate a multivalent epitope vaccine. …”
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    Immunoinformatics design of multivalent epitope vaccine against monkeypox virus and its variants using membrane-bound, enveloped, and extracellular proteins as targets
  19. 1499
    Publicado 1956
    Tabla de Contenidos: “…La silueta de humo / por Julio Jiménez Rueda. Padre mercader Carlos Díaz Dufóo -- v. 2. Proteo / por Francisco Monterde. …”
    Libro
    Teatro mexicano del siglo XX
  20. 1500
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    La línea de sombra
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