Mostrando 241 - 260 Resultados de 15,611 Para Buscar '"pancreatic cancer"', tiempo de consulta: 8.21s Limitar resultados
  1. 241
  2. 242
    por Arlt, A, Schäfer, H, Kalthoff, H
    Publicado 2012
    “…Recently, three transcription factors—nuclear factor-κB (NF-κB), nuclear factor of activated T cells (NFAT) and nuclear factor-E2-related factor-2 (Nrf2)—have been shown to be crucial for tumor development and chemoresistance in pancreatic cancer. These transcription factors are key regulators of a variety of genes involved in nearly all aspects of tumorigenesis and resistance against chemotherapeutics and death receptor ligands. …”
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    “…BACKGROUND: This retrospective study aimed to evaluate clinicopathological findings of remnant pancreatic cancers in survivors of invasive ductal adenocarcinomas of the pancreas (PDAC). …”
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  6. 246
    “…BACKGROUND: MicroRNA-34a (miR-34a) is a transcriptional target of p53 and is down-regulated in pancreatic cancer. This study aimed to investigate the functional significance of miR-34a in pancreatic cancer progression through its epigenetic restoration with chromatin modulators, demethylating agent 5-Aza-2′-deoxycytidine (5-Aza-dC) and HDAC inhibitor Vorinostat (SAHA). …”
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  7. 247
    “…However, there is little published information regarding the underlying clinical significance and mechanisms of transcription factor Nanog in pancreatic cancer. In this study, our results indicated that Nanog is overexpressed in human pancreatic cancer stem cells and downregulated by QYHJ, which may contribute to explain the clinical effectiveness of QYHJ and provide advanced pancreatic cancer patients with a new therapeutic option, supporting our hypothesis that the degradation pathway is another mechanism by which QYHJ affects Nanog expression.…”
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  13. 253
    por Lin, Xiao, Cui, Chunmei, Cui, Qinghua
    Publicado 2023
    “…With overall five-year survival rate less than 10%, pancreatic cancer (PC) represents the most lethal one in all human cancers. …”
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  14. 254
    “…SIMPLE SUMMARY: The poor prognosis of pancreatic cancer (PC) is associated with several factors, such as diagnosis at an advanced stage, early distant metastases, and remarkable resistance to most conventional treatment options. …”
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    “…SIMPLE SUMMARY: Pancreatic cancer has one of the worst prognoses among all the malignancies. …”
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    “…Pancreatic cancer is a malignant disease characterized by low survival and high recurrence rate, whose patients are mostly at the stage of locally advanced or metastatic disease when first diagnosed. …”
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  19. 259
    “…Pancreatic cancer is fast becoming a global menace and it is projected to be the second leading cause of cancer-related death by 2030. …”
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  20. 260
    “…SIMPLE SUMMARY: Pancreatic cancer is associated with poor outcomes for several reasons, including diagnosis at an advanced stage, the absence of effective screening for the diagnosis, and resistance to treatments. …”
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