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2761“…The treatment paradigm for locally advanced pancreatic cancer (LAPC) is evolving rapidly. The development of neoadjuvant therapies composed of combination therapies and the evaluation of their impact on conversion to borderline resectable (BR) status, resection, and ultimately overall survival (OS) are presently being pursued. …”
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2762“…Pancreatic cancer is a very aggressive disease with 5-year survival rates of less than 10%. …”
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2763por Abi Jaoude, Joseph, Thunshelle, Connor P., Kouzy, Ramez, Nguyen, Nicholas D., Lin, Daniel, Prakash, Laura, Bumanlag, Isabela M., Noticewala, Sonal S., Niedzielski, Joshua S., Beddar, Sam, Ludmir, Ethan B., Holliday, Emma B., Das, Prajnan, Minsky, Bruce D., Herman, Joseph M., Katz, Matthew, Koong, Albert C., Koay, Eugene J., Taniguchi, Cullen M.“…PURPOSE: Patients with pancreatic cancer often receive radiation therapy before undergoing surgical resection. …”
Publicado 2021
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2764por Sugimoto, Mitsuru, Takagi, Tadayuki, Suzuki, Rei, Konno, Naoki, Asama, Hiroyuki, Sato, Yuki, Irie, Hiroki, Okubo, Yoshinori, Nakamura, Jun, Takasumi, Mika, Hashimoto, Minami, Kato, Tsunetaka, Kobashi, Ryoichiro, Hikichi, Takuto, Ohira, Hiromasa“…BACKGROUND: The prognosis of pancreatic cancer (PC) has been improved by new chemotherapy regimens (combination of 5-fluorouracil, oxaliplatin, irinotecan, and leucovorin (FOLFIRINOX) or gemcitabine plus nab-paclitaxel (GnP)). …”
Publicado 2021
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2766“…Pancreatic cancer (PC) is one of the most lethal forms of cancer, characterized by its aggressiveness and metastatic potential. …”
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2767por Lu, Ye, Gentiluomo, Manuel, Macauda, Angelica, Gioffreda, Domenica, Gazouli, Maria, Petrone, Maria C., Kelemen, Dezső, Ginocchi, Laura, Morelli, Luca, Papiris, Konstantinos, Greenhalf, William, Izbicki, Jakob R., Kiudelis, Vytautas, Mohelníková-Duchoňová, Beatrice, Bueno-de-Mesquita, Bas, Vodicka, Pavel, Brenner, Hermann, Diener, Markus K., Pezzilli, Raffaele, Ivanauskas, Audrius, Salvia, Roberto, Szentesi, Andrea, Aoki, Mateus Nóbrega, Németh, Balázs C., Sperti, Cosimo, Jamroziak, Krzysztof, Chammas, Roger, Oliverius, Martin, Archibugi, Livia, Ermini, Stefano, Novák, János, Kupcinskas, Juozas, Strouhal, Ondřej, Souček, Pavel, Cavestro, Giulia M., Milanetto, Anna C., Vanella, Giuseppe, Neoptolemos, John P., Theodoropoulos, George E., van Laarhoven, Hanneke W. M., Mambrini, Andrea, Moz, Stefania, Kala, Zdenek, Loveček, Martin, Basso, Daniela, Uzunoglu, Faik G., Hackert, Thilo, Testoni, Sabrina G. G., Hlaváč, Viktor, Andriulli, Angelo, Lucchesi, Maurizio, Tavano, Francesca, Carrara, Silvia, Hegyi, Péter, Arcidiacono, Paolo G., Busch, Olivier R., Lawlor, Rita T., Puzzono, Marta, Boggi, Ugo, Guo, Feng, Małecka-Panas, Ewa, Capurso, Gabriele, Landi, Stefano, Talar-Wojnarowska, Renata, Strobel, Oliver, Gao, Xin, Vashist, Yogesh, Campa, Daniele, Canzian, Federico“…Although 21 pancreatic cancer susceptibility loci have been identified in individuals of European ancestry through genome-wide association studies (GWASs), much of the heritability of pancreatic cancer risk remains unidentified. …”
Publicado 2021
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2768por Huffman, Deanna L, Vusqa, Urwat T, Shankar, Karthik, Alnimer, Lynna, Samhouri, Yazan, Srinivasamaharaj, Srividya, Malayala, Srikrishna V, Monga, Dulabh“…We aim to review rates of palliative care consultation in patients with advanced pancreatic cancer at our institution, intending to improve these rates. …”
Publicado 2021
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2769“…Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) is one of the seven isoforms of NOX family, which is upregulated in pancreatic cancer cell, mouse model of pancreatic cancer and human pancreatic cancer tissue. …”
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2770“…This is particularly evident in pancreatic cancer, where limited responses to treatment underlie dismal survival rates, highlighting the urgent need for new therapeutic approaches. …”
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2771“…Pancreatic cancer is associated with highly malignant tumors and poor prognosis due to strong therapeutic resistance. …”
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2772por Carrato, A., Cerezo, L., Feliu, J., Macarulla, T., Martín-Pérez, E., Vera, R., Álvarez, J., Botella-Carretero, J. I.“…PURPOSE: Malnutrition is a common problem among pancreatic cancer (PC) patients that negatively impacts on their quality of life (QoL) and clinical outcomes. …”
Publicado 2021
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2773por Pratt, Hillary G., Steinberger, Kayla J., Mihalik, Nicole E., Ott, Sascha, Whalley, Thomas, Szomolay, Barbara, Boone, Brian A., Eubank, Timothy D.“…Uncovering innovative therapeutic modalities to target the resistance mechanisms that make pancreatic cancer largely incurable are urgently needed. …”
Publicado 2021
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2774por Zhang, Xiaofei, Mao, Tiebo, Zhang, Bei, Xu, Haiyan, Cui, Jiujie, Jiao, Feng, Chen, Dongqin, Wang, Yu, Hu, Jiong, Xia, Qing, Li, Shumin, Yue, Ming, Ma, Jingyu, Yao, Jiayu, Wang, Yongchao, Zhang, Xiao, Chen, Shiqing, Bai, Yuezong, Wang, Yuexiang, Zhang, Xuebin, Liu, Qiang, Sun, Yongwei, Fu, Deliang, Liu, Yingbin, Xiong, Lei, Wang, LiweiEnlace del recurso
Publicado 2021
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2775por De Sanctis, Francesco, Lamolinara, Alessia, Boschi, Federico, Musiu, Chiara, Caligola, Simone, Trovato, Rosalinda, Fiore, Alessandra, Frusteri, Cristina, Anselmi, Cristina, Poffe, Ornella, Cestari, Tiziana, Canè, Stefania, Sartoris, Silvia, Giugno, Rosalba, Del Rosario, Giulia, Zappacosta, Barbara, Del Pizzo, Francesco, Fassan, Matteo, Dugnani, Erica, Piemonti, Lorenzo, Bottani, Emanuela, Decimo, Ilaria, Paiella, Salvatore, Salvia, Roberto, Lawlor, Rita Teresa, Corbo, Vincenzo, Park, Youngkyu, Tuveson, David A, Bassi, Claudio, Scarpa, Aldo, Iezzi, Manuela, Ugel, Stefano, Bronte, Vincenzo“…We examined the impact of pharmacological RNS interference on overcoming the recruitment and immunosuppressive activity of tumor-expanded myeloid cells, which render pancreatic cancers resistant to immunotherapy. RESULTS: PDAC progression is marked by a stepwise infiltration of myeloid cells, which enforces a highly immunosuppressive microenvironment through the uncontrolled metabolism of L-arginine by arginase 1 and inducible nitric oxide synthase activity, resulting in the production of large amounts of reactive oxygen and nitrogen species. …”
Publicado 2022
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2776“…Pancreatic cancer is one of the most common malignancies. …”
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2777por Wang, Dandan, Liu, Ruifeng, Zhang, Qiuning, Luo, Hongtao, Chen, Junru, Dong, Meng, Wang, Yuhang, Ou, Yuhong, Liu, Zhiqiang, Sun, Shilong, Yang, Kehu, Tian, Jinhui, Li, Zheng, Wang, Xiaohu“…PURPOSE: Given the higher precision accompanied by optimized sparing of normal tissue, charged particle therapy was thought of as a promising treatment for pancreatic cancer. However, systematic preclinical studies were scarce. …”
Publicado 2022
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2778“…Dense fibrotic stroma, known as desmoplasia, is a characteristic feature of pancreatic cancer, and develops through the interactions between pancreatic cancer cells and stromal cells, including pancreatic stellate cells. …”
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2779por Laface, Carmelo, Laforgia, Mariarita, Molinari, Pasquale, Foti, Caterina, Ambrogio, Francesca, Gadaleta, Cosmo Damiano, Ranieri, Girolamo“…SIMPLE SUMMARY: Pancreatic cancer has a very poor prognosis. The few available therapeutic options are characterized by low efficacy and high toxicity due to the intrinsic chemoresistance of this tumor type. …”
Publicado 2022
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2780por Gdowski, Andrew, Hayatshahi, Hamed, Fudala, Rafal, Joshi, Rohan, Liu, Jin, Vishwanatha, Jamboor K., Jeyarajah, Rohan, Guzik, Paul, Ranjan, Amalendu P.Enlace del recurso
Publicado 2022
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