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  1. 3861
    “…Pancreatic cancer is one of the most aggressive forms of cancer and is the seventh leading cause of cancer deaths worldwide. …”
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    Multifaceted Effects of Kinase Inhibitors on Pancreatic Cancer Cells Reveals Pivotal Entities with Therapeutic Implications
  2. 3862
    “…Oncogenic KRAS activation, inflammation and p53 mutation are key drivers of pancreatic cancer (PC) development. Here we report iASPP, an inhibitor of p53, as a paradoxical suppressor of inflammation and oncogenic KRAS(G12D)-driven PC tumorigenesis. iASPP suppresses PC onset driven by KRAS(G12D) alone or KRAS(G12D) in combination with mutant p53(R172H). iASPP deletion limits acinar-to-ductal metaplasia (ADM) in vitro but accelerates inflammation and KRAS(G12D)-induced ADM, pancreatitis and PC tumorigenesis in vivo. …”
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    p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer
  3. 3863
    “…BACKGROUND: In the United States, the incidence and prevalence of pancreatic cancer are well-established relative to the factors of gender and race. …”
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    Gender and racial disparities in the incidence and mortality of pancreatic cancer in Mississippi State from 2003 to 2019
  4. 3864
    “…SIMPLE SUMMARY: Pancreatic cancer remains a major therapeutic challenge despite medical advances. …”
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    State-of-the-Art and Upcoming Innovations in Pancreatic Cancer Care: A Step Forward to Precision Medicine
  5. 3865
    “…Pancreatic cancer is an aggressive malignant cancer that shows the lowest survival rates. …”
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    Clinical features and prognostic factors of spinal metastatic pancreatic cancer: A retrospective observational study
  6. 3866
    “…Pancreatic cancer is a leading cause of cancer death due to its early metastasis and limited response to the current therapies. …”
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    High-throughput functional screen identifies YWHAZ as a key regulator of pancreatic cancer metastasis
  7. 3867
    “…The ability of CAR-T to kill pancreatic cancer cells is tested in vitro and in vivo, and the safety is evaluated in mice and nonhuman primate. …”
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    GAS6-based CAR-T cells exhibit potent antitumor activity against pancreatic cancer
  8. 3868
    “…We aimed to investigate the effects of plasma lipids on the prognosis of patients with pancreatic cancer and the infiltration of CD8+ T lymphocytes in tumour tissue. …”
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    Plasma lipid levels are associated with the CD8+ T‐cell infiltration and prognosis of patients with pancreatic cancer
  9. 3869
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    Induction of cancer neoantigens facilitates development of clinically relevant models for the study of pancreatic cancer immunobiology
  10. 3870
    “…Here, we report that phosphodiesterase 4D (PDE4D) promotes pancreatic cancer tumor growth by increasing mTORC1 signaling. …”
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    Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth
  11. 3871
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    Semaphorin 3 C enhances putative cancer stemness and accelerates peritoneal dissemination in pancreatic cancer
  12. 3872
    “…Employing ns-APPJ powered by 9 kV, 200 ns pulses at 2 kHz and 60-nsPEF of 50 kV/cm at 1 Hz, the synergistic effects on pancreatic cancer cells (Pan02) in vitro were evaluated on cell viability and transcellular electrical resistance (TER). …”
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    Synergistic effects of nanosecond pulsed plasma and electric field on inactivation of pancreatic cancer cells in vitro
  13. 3873
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    Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression
  14. 3874
    “…To study the biological function of IL-1Ra in tumors, we generated a set of mouse pancreatic cancer cell lines with a knockout (KO) of the Il1rn gene, encoding IL-1Ra, and compared the tumor growth rates in immune-competent and immune-deficient mice. …”
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    Tumor-derived interleukin-1 receptor antagonist exhibits immunosuppressive functions and promotes pancreatic cancer
  15. 3875
    “…RESULTS: It revealed that umbelliprenin inhibited pancreatic cancer cell proliferation in vitro and pancreatic cancer tumor growth in vivo. …”
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    Umbelliprenin induces autophagy and apoptosis while inhibits cancer cell stemness in pancreatic cancer cells
  16. 3876
    por Sun, Hang, Wang, Yan, Yang, Huayu
    Publicado 2023
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    Revolutionizing preclinical research for pancreatic cancer: the potential of 3D bioprinting technology for personalized therapy
  17. 3877
    por Posta, Máté, Győrffy, Balázs
    Publicado 2023
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    Analysis of a large cohort of pancreatic cancer transcriptomic profiles to reveal the strongest prognostic factors
  18. 3878
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    Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis
  19. 3879
    “…METHODS: Computed tomography images of 304 patients undergoing elective pancreatic cancer resection were analysed. 2D radiomics features were extracted from skeletal muscle and subcutaneous and visceral adipose tissue (SAT and VAT) compartments from a single slice at the third lumbar vertebra. …”
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    Identifying radiomics signatures in body composition imaging for the prediction of outcome following pancreatic cancer resection
  20. 3880
    “…BACKGROUND: Pancreatic cancer is the 4th leading cause of cancer-related death with poor survival even after curative resection. …”
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    RAB27B expression in pancreatic cancer is predictive of poor survival but good response to chemotherapy
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