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1061por Kwon, Jason J., Nabinger, Sarah C., Vega, Zachary, Sahu, Smiti Snigdha, Alluri, Ravi K., Abdul-Sater, Zahi, Yu, Zhangsheng, Gore, Jesse, Nalepa, Grzegorz, Saxena, Romil, Korc, Murray, Kota, Janaiah“…Dense fibrotic stroma associated with pancreatic ductal adenocarcinoma (PDAC) is a major obstacle for drug delivery to the tumor bed and plays a crucial role in pancreatic cancer progression. Current, anti-stromal therapies have failed to improve tumor response to chemotherapy and patient survival. …”
Publicado 2015
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1062por Wu, Meng-Yao, Liang, Rong-Rui, Chen, Kai, Shen, Meng, Tian, Ya-Li, Li, Dao-Ming, Duan, Wei-Ming, Gui, Qi, Gong, Fei-Ran, Lian, Lian, Li, Wei, Tao, Min“…We investigated the inhibitory effect of FH535 on the metastasis and growth of pancreatic cancer cells. Western blotting and luciferase reporter gene assay indicated that FH535 markedly inhibited Wnt/β-catenin pathway viability in pancreatic cancer cells. …”
Publicado 2015
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1063por Nath, Sritama, Roy, Lopamudra Das, Grover, Priyanka, Rao, Shanti, Mukherjee, PinkuEnlace del recurso
Publicado 2015
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1064“…Pancreatic cancer is a complex and heterogeneous disease that often lacks disease-specific symptoms in early stages. …”
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1065por Chang, Aeson, Kim-Fuchs, Corina, Le, Caroline P., Hollande, Frédéric, Sloan, Erica K.“…They also provide evidence to support the use of β-blockers as a novel therapeutic intervention to complement current clinical strategies to improve cancer outcome in patients with pancreatic cancer.…”
Publicado 2015
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1066por Beltrame, Valentina, Gruppo, Mario, Pedrazzoli, Sergio, Merigliano, Stefano, Pastorelli, Davide, Sperti, Cosimo“…Between January 1998 and December 2012, 241 patients with pancreatic cancer underwent pancreatic resection: in 64 patients, surgery included venous resection for macroscopic invasion of mesenteric-portal vein axis. …”
Publicado 2015
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1067por Zhang, Qiang, Sun, Xiaotian, Yang, Jingxuan, Ding, Hao, LeBrun, Drake, Ding, Kai, Houchen, Courtney W., Postier, Russell G., Ambrose, Catherine G., Li, Zhaoshen, Bi, Xiaohong, Li, Min“…Metabolic bone disorders are associated with several types of human cancers. Pancreatic cancer patients usually suffer from severe nutrition deficiency, muscle wasting, and loss of bone mass. …”
Publicado 2015
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1068“…BACKGROUND: Studies document that magnesium is inversely associated with the risk of diabetes, which is a risk factor of pancreatic cancer. However, studies on the direct association of magnesium with pancreatic cancer are few and findings are inconclusive. …”
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1069por Tsang, Yiu Huen, Dogruluk, Turgut, Tedeschi, Philip M., Wardwell-Ozgo, Joanna, Lu, Hengyu, Espitia, Maribel, Nair, Nikitha, Minelli, Rosalba, Chong, Zechen, Chen, Fengju, Chang, Qing Edward, Dennison, Jennifer B., Dogruluk, Armel, Li, Min, Ying, Haoqiang, Bertino, Joseph R., Gingras, Marie-Claude, Ittmann, Michael, Kerrigan, John, Chen, Ken, Creighton, Chad J., Eterovic, Karina, Mills, Gordon B., Scott, Kenneth L.Enlace del recurso
Publicado 2016
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1071“…Of interest, gastrin is expressed in the embryologic pancreas but not in the adult pancreas; however, gastrin becomes re-expressed in pancreatic cancer where it stimulates growth of this malignancy by an autocrine mechanism. …”
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1074por Park, Hee ChulEnlace del recurso
Publicado 2016
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1075por Bimonte, Sabrina, Barbieri, Antonio, Leongito, Maddalena, Palma, Giuseppe, del Vecchio, Vitale, Falco, Michela, Palaia, Raffaele, Albino, Vittorio, Piccirillo, Mauro, Amore, Alfonso, Petrillo, Antonella, Granata, Vincenza, Izzo, Francesco“…Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. …”
Publicado 2016
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1076“…We will summarize the state-of-the-art for each direction, focusing on efforts directed toward the development of therapeutics for pancreatic cancer patients with mutated KRAS.…”
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1077“…Herein, we found that mogroside V possesses tumor growth inhibitory activity in in vitro and in vivo models of pancreatic cancer by promoting apoptosis and cell cycle arrest of pancreatic cancer cells (PANC-1 cells), which may in part be mediated through regulating the STAT3 signaling pathway. …”
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1078por Zheng, Xiaofeng, Carstens, Julienne L., Kim, Jiha, Scheible, Matthew, Kaye, Judith, Sugimoto, Hikaru, Wu, Chia-Chin, LeBleu, Valerie S., Kalluri, RaghuEnlace del recurso
Publicado 2015
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1079por Lee, Hee Seung, Lee, Sang Hoon, Lee, Hyun Jik, Chung, Moon Jae, Park, Jeong Youp, Park, Seung Woo, Song, Si Young, Bang, Seungmin“…We investigated whether statins used after pancreatic cancer diagnosis are associated with longer survival in pancreatic cancer patients. …”
Publicado 2016
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1080por Wang, Xiaoyun, Chow, Christina R., Ebine, Kazumi, Lee, Jiyoung, Rosner, Marsha R., Pan, Tao, Munshi, Hidayatullah G.“…Overall, our findings demonstrate the interaction of tRNA with MEK2 in pancreatic cancer cells and suggest that tRNA may impact MEK2 activity in cancer cells.…”
Publicado 2016
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