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1241“…Cutaneous involvement in pancreatic cancer represents poor survival with widespread dissemination of the disease. …”
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1242por Abu-Shawer, Osama, Abu-Shawer, Mohammad, Shurman, Abdullah, Lattouf, Ali, Haimour, Ayman, Hamdan, Omar, Mansour, Razan, Altamimi, Tamer, Al-Hussaini, Maysa“…BACKGROUND: Elevated neutrophil-lymphocyte ratio (NLR) is linked to poor overall survival (OS) in pancreatic cancer. We aim to investigate the association of the various hematologic markers, in particular NLR among others, with distant metastases, a common feature in pancreatic cancer. …”
Publicado 2020
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1243“…Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is characterized by highly hypoxic tumor microenvironment. …”
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1244por Goldstein, David, Von Hoff, Daniel D., Chiorean, E. Gabriela, Reni, Michele, Tabernero, Josep, Ramanathan, Ramesh K., Botteman, Marc, Aly, Abdalla, Margunato-Debay, Sandra, Lu, Brian, Louis, Chrystal U., McGovern, Desmond, Lee, Chee Khoon“…OBJECTIVES: This analysis investigated nomogram use to evaluate metastatic pancreatic cancer prognosis. METHODS: Thirty-four baseline factors were examined in the Metastatic Pancreatic Adenocarcinoma Clinical Trial (MPACT) (nab-paclitaxel plus gemcitabine vs gemcitabine) data set. …”
Publicado 2020
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1245
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1246por Tuli, Richard, David, John, Lobaugh, Stephanie, Zhang, Zhigang, O'Reilly, Eileen M.Enlace del recurso
Publicado 2020
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1247“…Pancreatic cancer has the worst prognosis and lowest survival rate among all types of cancers and thus, there exists a strong need for novel therapeutic strategies. …”
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1248por Dreyer, Stephan B., Pinese, Mark, Jamieson, Nigel B., Scarlett, Christopher J., Colvin, Emily K., Pajic, Marina, Johns, Amber L., Humphris, Jeremy L., Wu, Jianmin, Cowley, Mark J., Chou, Angela, Nagrial, Adnan M., Chantrill, Lorraine, Chin, Venessa T., Jones, Marc D., Moran-Jones, Kim, Carter, Christopher Ross, Dickson, Euan J., Samra, Jaswinder S., Merrett, Neil D., Gill, Anthony J., Kench, James G., Duthie, Fraser, Miller, David K., Cooke, Susanna, Aust, Daniela, Knösel, Thomas, Rümmele, Petra, Grützmann, Robert, Pilarsky, Christian, Nguyen, Nam Q., Musgrove, Elizabeth A., Bailey, Peter J., McKay, Colin J., Biankin, Andrew V., Chang, David K.“…Improving patient selection is of vital importance for the operative treatment of pancreatic cancer (pancreatic ductal adenocarcinoma). Although surgery is the only chance of long-term survival, 80% still succumb to the disease and approximately 30% die within 1 year, often sooner than those that have unresected local disease. …”
Publicado 2020
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1249“…As we expected, our model is able to simulate the pancreatic cancer growth at early stages, which is calibrated with experimental results. …”
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1250por Biederstädt, Alexander, Hassan, Zonera, Schneeweis, Christian, Schick, Markus, Schneider, Lara, Muckenhuber, Alexander, Hong, Yingfen, Siegers, Gerrit, Nilsson, Lisa, Wirth, Matthias, Dantes, Zahra, Steiger, Katja, Schunck, Kathrin, Langston, Steve, Lenhof, H-P, Coluccio, Andrea, Orben, Felix, Slawska, Jolanta, Scherger, Anna, Saur, Dieter, Müller, Stefan, Rad, Roland, Weichert, Wilko, Nilsson, Jonas, Reichert, Maximilian, Schneider, Günter, Keller, UlrichEnlace del recurso
Publicado 2020
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1251por Garcia, Paloma E., Adoumie, Maeva, Kim, Esther C., Zhang, Yaqing, Scales, Michael K., El-Tawil, Yara S., Shaikh, Amara Z., Wen, Hui-Ju, Bednar, Filip, Allen, Ben L., Wellik, Deneen M., Crawford, Howard C., Pasca di Magliano, Marina“…BACKGROUND & AIMS: Although the healthy pancreas consists mostly of epithelial cells, pancreatic cancer and the precursor lesions known as pancreatic intraepithelial neoplasia, are characterized by an extensive accumulation of fibroinflammatory stroma that includes a substantial and heterogeneous fibroblast population. …”
Publicado 2020
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1253por Takeda, Yu, Kobayashi, Shogo, Kitakaze, Masatoshi, Yamada, Daisaku, Akita, Hirofumi, Asai, Ayumu, Konno, Masamitsu, Arai, Takahiro, Kitagawa, Toru, Ofusa, Ken, Yabumoto, Masami, Hirotsu, Takaaki, Vecchione, Andrea, Taniguchi, Masateru, Doki, Yuichiro, Eguchi, Hidetoshi, Ishii, Hideshi“…However, EXs and immune checkpoint mechanisms in pancreatic cancer are not fully understood, we provide an update on the recent advances in this field and evidence that EXs will be useful for maximizing patient benefit in precision medicine.…”
Publicado 2020
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1254“…Obesity is a known risk factor for the development of pancreatic cancer, one of the deadliest types of malignancies. …”
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1255“…Pancreatic cancer has one of the poorest prognoses of all malignancies, with little improvement in clinical outcome over the past 40 years. …”
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1256por Oni, Tobiloba E., Biffi, Giulia, Baker, Lindsey A., Hao, Yuan, Tonelli, Claudia, Somerville, Tim D.D., Deschênes, Astrid, Belleau, Pascal, Hwang, Chang-il, Sánchez-Rivera, Francisco J., Cox, Hilary, Brosnan, Erin, Doshi, Abhishek, Lumia, Rebecca P., Khaledi, Kimia, Park, Youngkyu, Trotman, Lloyd C., Lowe, Scott W., Krasnitz, Alexander, Vakoc, Christopher R., Tuveson, David A.Enlace del recurso
Publicado 2020
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1257por Dulskas, Audrius, Patasius, Ausvydas, Linkeviciute-Ulinskiene, Donata, Zabuliene, Lina, Smailyte, Giedre“…Background: We assessed the association between the use of metformin and other antihyperglycemic medications on overall survival in diabetic patients with pancreatic cancer. Methods: Patients with pancreatic cancer and diabetes between 2000 and 2015 were identified from the Lithuanian Cancer Registry and the National Health Insurance Fund database. …”
Publicado 2020
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1258por Boas, F. Edward, Nurili, Fuad, Bendet, Achiude, Cheleuitte-Nieves, Christopher, Basturk, Olca, Askan, Gokce, Michel, Adam O., Monette, Sebastien, Ziv, Etay, Sofocleous, Constantinos T., Maxwell, Aaron W. P., Schook, Lawrence B., Solomon, Stephen B., Kelsen, David P., Scherz, Avigdor, Yarmohammadi, Hooman“…BACKGROUND: Preclinical testing of new locoregional therapies for pancreatic cancer has been challenging, due to the lack of a suitable large animal model. …”
Publicado 2020
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1259por Martin-Perez, E., Domínguez-Muñoz, J. E., Botella-Romero, F., Cerezo, L., Matute Teresa, F., Serrano, T., Vera, R.“…Pancreatic cancer (PC) remains one of the most aggressive tumors with an increasing incidence rate and reduced survival. …”
Publicado 2020
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1260“…The aggressive and therapy-resistant nature of pancreatic cancer warrants the need for novel treatment options for pancreatic cancer management. …”
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