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121“…Pancreatic cancer is a deadly disease with an extremely poor 5-year survival rate due to treatment resistance and late-stage detection. …”
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122“…About 80% of pancreatic cancer patients have glucose intolerance or frank diabetes. …”
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123por Korc, M“…Recent studies indicate that suppression of VEGF expression attenuates pancreatic cancer cell tumorigenicity in a nude mouse model, and that VEGF can exert direct mitogenic effects on some pancreatic cancer cells. …”
Publicado 2003
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124“…Pancreatic cancer is a largely chemo-resistant disease with a poor prognosis. …”
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125“…This article reviews the evidence supporting EGFR inhibition and the use of erlotinib in advanced pancreatic cancer as well as future implications of targeted therapy in this challenging malignancy.…”
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127“…Pancreatic cancer is a devastating disease with the worst mortality rate and an overall 5-year survival rate lower than 5%. …”
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128“…Is depression in patients suffering from pancreatic cancer just due to the confrontation with a life threatening disease and its somatic symptoms or is depression in this particular group of patients a feature of pancreatic cancer per se? …”
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129por Sherman, Simon, Shats, Oleg, Ketcham, Marsha A., Anderson, Michelle A., Whitcomb, David C., Lynch, Henry T., Ghiorzo, Paola, Rubinstein, Wendy S., Sasson, Aaron R., Grizzle, William E., Haynatzki, Gleb, Feng, Jianmin, Sherman, Alexander, Kinarsky, Leo, Brand, Randall E.“…The Pancreatic Cancer Collaborative Registry (PCCR) is a multi-institutional web-based system aimed to collect a variety of data on pancreatic cancer patients and high-risk subjects in a standard and efficient way. …”
Publicado 2011
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130por Koido, Shigeo, Homma, Sadamu, Takahara, Akitaka, Namiki, Yoshihisa, Tsukinaga, Shintaro, Mitobe, Jimi, Odahara, Shunichi, Yukawa, Toyokazu, Matsudaira, Hiroshi, Nagatsuma, Keisuke, Uchiyama, Kan, Satoh, Kenichi, Ito, Masaki, Komita, Hideo, Arakawa, Hiroshi, Ohkusa, Toshifumi, Gong, Jianlin, Tajiri, Hisao“…Pancreatic cancer is a highly aggressive and notoriously difficult to treat. …”
Publicado 2011
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131por Saito, Yoshimasa, Suzuki, Hidekazu, Matsuura, Misa, Sato, Ayami, Kasai, Yusuke, Yamada, Kana, Saito, Hidetsugu, Hibi, Toshifumi“…In this review, we summarize current knowledge about the roles of important tumor suppressor microRNAs and oncogenic microRNAs in hepatobiliary and pancreatic cancers.…”
Publicado 2011
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132por Hammami, Mohamed, Noomen, Faouzi, Toumi, Omar, Harzallah, Olfa, Mahmoudi, Ammar, Kallel, Wassim, Zouari, Khadija, Hamdi, AbdelazizEnlace del recurso
Publicado 2011
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133“…Pancreatic cancer (PC) represents an unresolved therapeutic challenge, due to the poor prognosis and the reduced response to currently available treatments. …”
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134por Samm, Nicole, Werner, Kristin, Rückert, Felix, Saeger, Hans Detlev, Grützmann, Robert, Pilarsky, Christian“…Pancreatic cancer is a disease with high resistance to most common therapies and therefore has a poor prognosis, which is partly due to a lack of reaction to apoptotic stimuli. …”
Publicado 2010
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135“…Although it is still controversial whether this association exists for pancreatic cancer, biochemical evidence clearly indicates pancreatic cancer cells are responsive to the inhibitory effect of vitamin D and its analogs. …”
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136por Fulda, Simone“…The ability to escape apoptosis or programmed cell death is a hallmark of human cancers, for example pancreatic cancer. This can promote tumorigenesis, since too little cell death by apoptosis disturbs tissue homeostasis. …”
Publicado 2011
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137por Bao, Qi, Zhao, Yue, Renner, Andrea, Niess, Hanno, Seeliger, Hendrik, Jauch, Karl-Walter, Bruns, Christiane J.“…Increasing evidence indicates that pancreatic cancer is initiated and propagated by cancer stem cells (CSCs). …”
Publicado 2010
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138por Rustgi, Anil K.“…This review elaborates on the known genetic syndromes that underlie familial pancreatic cancer, where there are opportunities for genetic counseling and testing as well as clinical monitoring of at-risk patients. …”
Publicado 2014
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139por Weiss, Frank U.“…The long-lasting inflammation however generates a tumor promoting environment and represents a major risk factor for tumor development This review will reflect our knowledge concerning the specific risk of HP patients to develop pancreatic cancer.…”
Publicado 2014
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140por Nagpal, Gandharva, Sharma, Minakshi, Kumar, Shailesh, Chaudhary, Kumardeep, Gupta, Sudheer, Gautam, Ankur, Raghava, Gajendra P. S.“…Pancreatic cancer is the fifth most aggressive malignancy and urgently requires new biomarkers to facilitate early detection. …”
Publicado 2014
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