“…. • Earlier detection of active inflammation could have significant impact on treatment paradigms. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00330-017-5016-4) contains supplementary material, which is available to authorized users.…”
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“…Except for the control group, all rats were submitted to chronic unpredictable mild stress paradigms for four weeks to induce depressive behavior. …”
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“…We will discuss the fundamental mechanistic features of these transformations and delineate the underlying structural and electronic factors that contribute to the spectrum of reactivities that has been observed in nature as well as those that have been invented using these paradigms. Given the recent developments in biocatalysis for non-natural chemistries and the renaissance of radical chemistry in organic synthesis, we envision that new enzymatic and synthetic transformations will emerge based on the radical processes mediated by metalloproteins and their synthetic analogs.…”
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“…New optogenetic experimental paradigms based on spatial profiles or patterns of light stimulation offer the prospect of elucidating many aspects of single cell function, including the role of dendrites in gain control. …”
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“…PURPOSE: Current clinical perimetric test paradigms present stimuli randomly to various locations across the visual field (VF), inherently introducing spatial uncertainty, which reduces contrast sensitivity. …”
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“…Moreover, both sexes showed increased anxiety-related behavior in the elevated plus-maze (EPM) and open field (OF) paradigms. We assessed somatic pain levels, because they may influence behavioral responses. …”
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“…To do so, we employed pop-out and serial visual search paradigms, implemented using a novel smartphone application that allowed search times and self-rated levels of happiness to be recorded throughout each twenty-four-hour period for two weeks. …”
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“…More precisely, we performed three established behavioral paradigms measuring anxiety-like behavior and assessed corticosterone metabolites non-invasively via feces sampling. …”
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“…Additionally, since software and hardware provided here can be readily customized to achieve a large variety of paradigms, these solutions enable an unusually flexible design of rodent behavioral experiments.…”
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“…TMB users can fit the same model in both frequentist and Bayesian paradigms, including using NUTS to test the validity of the Laplace approximation of the marginal likelihood for arbitrary subsets of parameters. …”
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“…Male Wistar rats in two experimental groups were treated with escalating paradigms consisting of twice daily intraperitoneal injection of either 1-7 mg/kg or 1-14 mg/kg of MA over 14 days. …”
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“…RECENT FINDINGS: A number of seminal discoveries have recently been made in this area, shifting existing paradigms. The crystal structure of the ternary FGF receptor (FGFR)-1c/Klotho/FGF23 complex has been uncovered, revealing how the ligand FGF23 interacts with FGFR1c and the coreceptor Klotho at atomic resolution. …”
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“…Such stimulus sizes could potentially detect VF defects, on average, 4 years earlier than current paradigms. TRANSLATIONAL RELEVANCE: Stimulus sizes within or near Ac may be more suitable for early detection of glaucomatous VF defects. …”
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“…We then describe methods to study the complexity of the brain’s output streams or of brain state as correlates of conscious state: we review methods such as (i) probing the brain through its input streams (e.g. event-related potentials in oddball paradigms or mutual algorithmic information between world and brain), (ii) analyzing spontaneous brain state, (iii) perturbing the brain by non-invasive transcranial stimulation, and (iv) quantifying behavior (e.g. eye movements or body sway).…”
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“…Finally, the “dual intervention point” model combines both paradigms with two set points and a settling point between them. …”
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“…The glaring gaps in the delivery of TB services must be remedied, and some of these gaps will require new paradigms and ways of working which include patient-centered and higher-quality services. …”
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“…However, nowadays, sophisticated isolation technologies and deepened molecular understanding of the active ingredients of TCM are gradually bridging the gap between the two, enabling the identification of active TCM components for drug development under the western-style paradigms. Thus, studies on TCM open a new therapeutic avenue and show great potential in the combat against obesity, though challenges exist. …”
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“…Research into the neural correlates of consciousness and the theory of identity (in the philosophy of mind) are two major research paradigms that hitherto have had very little mutual contact. …”
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“…The aims of Saudi children’s overweight, obesity, and lifestyles study were to estimate the prevalence of the metabolic syndrome and to compare the different paradigms of assessing such risk among children and adolescents. …”
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“…Here, we use different 4PBA treatment paradigms to define therapeutic parameters for preventing cerebrovascular and muscular pathologies in Col4a1 mutant mice. …”
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