“…Several recent reviews have highlighted the fact that all longevity treatment paradigms to mitigate progression of aging-related pathologies converge in induction of autophagy, activation of AMP kinase (AMPK) and Sirtuin pathway, and inhibition of mechanistic target of rapamycin (mTOR). …”
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“…In a similar manner to other learning paradigms, intact muscarinic acetylcholine receptor (mAChR) neurotransmission or protein synthesis regulation in the anterior insular cortex (aIC) is necessary for appetitive taste learning. …”
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“…The effectiveness of the delivery platforms largely depends on their physicochemical nature, intracellular barriers, and biodistribution of the drugs, pharmacokinetics and pharmacodynamic paradigms. Most subcellular organelles possess some peculiar characteristics by which membranous and subcellular targeting can be manipulated, such as negative transmembrane potential in mitochondria, intraluminal delta pH in a lysosome, and many others. …”
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“…It has technological basis very close to the paradigms of Industry 4.0 (Ind-4.0), so that it is also often referred to as Agriculture 4.0. …”
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“…There is need for mouse paradigms to understand these contradictory effects. …”
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“…This outlook shows that although current ultrasonic systems do have some limitations in delivering the acoustic energy, further advance of this technique may lead to novel treatment paradigms. Furthermore, it highlights that new data streams from multipurpose electrodes and wireless transmission of intracranial recordings will become available soon once some critical developments will be achieved such as electrode fidelity, data processing and storage, heat conduction as well as rechargeable technology. …”
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“…Accordingly, we predicted three possible seed dispersal paradigms for animal‐dispersed pines: the first, as represented by Chinese white pine and Dabieshan white pine, relies upon small forest rodents for seed dispersal; the second, represented by Korean pine, relies primarily on birds and squirrels to disperse the seeds; and the third, represented by Siberian dwarf pine, relies primarily on birds for seed dispersal. …”
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“…Several hubness reduction methods based on different paradigms have previously been developed. Local and global scaling as well as shared neighbors approaches aim at repairing asymmetric neighborhood relations. …”
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“…Compared to conventional dose rate (CONV) irradiation, FLASH-RT was found to ameliorate radiation-induced cognitive dysfunction in multiple independent behavioral paradigms, preserve developing and mature neurons, minimize microgliosis and limit the reduction of the plasmatic level of growth hormone. …”
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“…However, collecting enough repeated trials is often impractical and even impossible in some paradigms, while analyses on existing data sets may be hampered when these do not contain such repeated trials. …”
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“…The article proposes a methodology for prediction of mental health disorders induced by the pandemic, which includes: Phase 1) objective assessment of the intensity of HCWs’ stressor exposure, based on information retrieved from hospital archives and clinical records; Phase 2) subjective self-report assessment of stress during the COVID-19 pandemic experienced by HCWs and their relevant psychological traits; Phase 3) design and development of appropriate multimodal stimulation paradigms to optimally elicit specific neuro-physiological reactions; Phase 4) objective measurement and computation of relevant neuro-physiological predictor features based on HCWs’ reactions; and Phase 5) statistical and machine learning analysis of highly heterogeneous data sets obtained in previous phases. …”
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“…Altruistic punishment—to punish someone who violates group norms even if it foresees a personal cost—is one of the most useful and fruitful paradigms; it allows to maintain a cooperation system within social groups. …”
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“…In this study we adapted prior testing paradigms to examine 5-year-olds’ understanding of balance and compared children’s learning about balance from evidence presented through primary sources (a guided activity) or secondary sources (picture books). …”
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“…Eventually, high temporal resolution fNIRS can be a promising tool for monitoring functional brain activation under the cognitive paradigms in neurological research and psychotherapy applications.…”
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“…This review will provide an overview of the current paradigms with an emphasis on the roles of immunometabolism and ROS in the context of IAV infection and secondary complications due to bacterial infection such as Streptococcus pneumoniae. …”
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“…This information could have implications for the design of visually guided tasks involving human body parts in both research and application or training-related paradigms.…”
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“…In this study, we examined variation in 5 urinary markers of oxidative damage and protection under 5 validation paradigms for 37 wild, chimpanzees living in the Kibale National Park, Uganda. …”
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“…These so‐called telehealth concepts or services help to implement closed‐loop healthcare paradigms and to establish collaborative care networks involving all stakeholders relevant to optimising the overall medication therapy. …”
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“…The innovation here lies in applying system dynamics modelling and simulation paradigms when designing the theoretical model of capability development, which forms the core of the expert system. …”
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“…Immune checkpoint inhibitors (ICIs) have recently changed therapeutic paradigms for patients across multiple cancer types. …”
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