“…ABSTRACT: The emergence of Trop-2 as a therapeutic target has given rise to new treatment paradigms for the treatment of patients with advanced and metastatic breast cancer. …”
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“…Additionally, we focused on evaluating these extracts’ anxiolytic- and antidepressant-like effects in behavioral predictive paradigms in mice. According to direct Principal Component Analysis (PCA) by NMR, and Direct Injection Electrospray Ionization-Mass Spectrometry (DIESI-MS), methanol extracts obtained after resin treatment were free of coumarin compounds and evinced had a high content of naringin. …”
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“…The aim of this review is to explore the potential health challenges associated with space travel and how they may be overcome in order to enable new paradigms for space health, as well as the use of emerging Artificial Intelligence based (AI) technology to propel future space health research.…”
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“…We now report that these neuropeptides exhibited opposite effects in in vivo paradigms, in which ligands of the sigma type 1 receptor (σ1R) displayed positive effects. …”
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“…Many scopes under the five themes were left unexplored, such as emerging paradigms of Internet of things (IoT) and blockchain under the theme of “digitalization,” hybrid models (e.g., game theory and genetic algorithms) under the theme of “methodology and techniques,” and social responsibility under the theme of “environmental issues.”…”
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“…Our results therefore encourage the use of web-testing in the domain of cognitive psychology, even when using complex paradigms. Nevertheless, these results urge for caution regarding how researchers select web-based participant pools when conducting online research.…”
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“…We found motor imagery (MI) or motor attempt (MA) are common experimental paradigms in EEG-based BCIs trials. Imagining/attempting to grasp and extend the fingers is the most common, and there were multi-joint movements, including wrist, elbow, and shoulder. …”
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“…We provide such examples from assessing the role of risks factors. In conclusion, new paradigms and new designs schemes are needed in order to reach inferential conclusions that are meaningful and informative when dealing with data collected during emergencies like COVID-19.…”
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“…This review encompassed the following three subjects, with a focus on recently reported and ongoing clinical trials: (1) the use of neoadjuvant immunotherapy prior to surgery for locally advanced HNSCC, (2) the use of immunochemoradiotherapy for locally advanced head and neck cancers, and (3) novel uses of immunotherapy in the salvage of recurrent/metastatic HNSCC via a combined modality, including reirradiation paradigms. The results of these studies are eagerly awaited to improve patient outcomes in this challenging disease.…”
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“…In our laboratory, we have recently shown that physical exercise induces the long-lasting enhancement of subventricular (SVZ) adult neurogenesis in a p21 (negative regulator of neural progenitor proliferation)-null mice model, with a concomitant improvement of olfactory behavioral paradigms that are strictly dependent on SVZ neurogenesis. …”
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“…Experiments reveal the AI-based method which joins the multitask learning, and single agent reinforcement learning paradigms enable agents to work in local region, alleviating the time-consuming problem of SARLM, performing location task in a global scope, and improving the location accuracy of ILM, thus reflecting its effectiveness and clinical application value in the task of rapidly and accurately measuring the diameter of CSCR lesions.…”
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“…The relationship of cannabis-use disorder and trauma exposure at the level of the brain is not well-understood. Cue-reactivity paradigms have largely focused on characterizing aberrant subcortical function by averaging across the entire task. …”
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“…Aspects of glutamate neurotransmission implicated in normal and pathological conditions are often evaluated using in vivo recording paradigms in rats anesthetized with isoflurane or urethane. …”
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“…Evolution algorithms, which are derived from evolutionary mechanisms such as natural selection and genetics, have been widely employed to develop and optimize NAS because they can handle a blackbox optimization process for designing appropriate solution representations and search paradigms without explicit mathematical formulations or gradient information. …”
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“…The results break ground for possible new paradigms for genome acetylation in hESCs that could lead to new avenues for therapeutic intervention in cancer and developmental diseases.…”
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“…Although the presented results are for the resting-state, they may serve as a baseline for other paradigms.…”
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“…More recent studies yielded equivocal evidence for a stress-induced shift towards habitual responding, yet these studies used different paradigms to evaluate instrumental learning or used different stressors. …”
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“…Urea cycle disorders (UCD) are inborn errors of metabolism caused by deficiency of enzymes required to convert nitrogen from ammonia into urea. Current paradigms of treatment focus on dietary manipulations, ammonia scavenger drugs, and liver transplantation. …”
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“…Overall, we found that perceptual training can rapidly improve performance on a difficult radiology task, albeit not to a comparable level as expert performance, and that similar levels of performance were achieved across the perceptual training paradigms we compared. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s41235-023-00467-0.…”
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“…Third, analyzing which intellectual foundations are primarily cited in each current research stream unveils the dominant theoretical paradigms in the current state of research. Analyzing 570 published studies, we identified four intellectual foundations of entrepreneurship in family firms: socioemotional wealth (SEW), entrepreneurial orientation, family-embedded resources, and agency theory. …”
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