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  1. 39921
    “…The aim of this study was to explore which of these treatment paradigms is the superior technique in cervical treatment, taking clinical outcomes and treatment efficiency from published findings into consideration. …”
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    Dosimetric comparison of volumetric-modulated arc therapy and intensity-modulated radiation therapy in patients with cervical cancer: a meta-analysis
  2. 39922
    “…In the current experiments, we used two different voluntary running paradigms to examine how exercise impacts adult neurogenesis in the dorsal and ventral hippocampal dentate gyrus (DG) of Fmr1 KO mice. …”
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    Effects of Voluntary Exercise on Cell Proliferation and Neurogenesis in the Dentate Gyrus of Adult FMR1 Knockout Mice
  3. 39923
    “…Therefore, our aims were to define the types of synapses formed by AVP+ fibers with LC neurons using immunohistochemistry together with confocal and transmission electron microscopy (TEM), the origins of such inputs, using retrograde tracers, and the plasticity of the LC AVP system in response to stress and spatial learning, using the maternal separation (MS) and Morris water maze (MWM) paradigms, respectively, in rat. Confocal microscopy revealed that AVP+ fibers contacting tyrosine hydroxylase (TH)+ LC neurons were also immunopositive for vesicular glutamate transporter 2, a marker of presynaptic glutamatergic axons. …”
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    A Synaptically Connected Hypothalamic Magnocellular Vasopressin-Locus Coeruleus Neuronal Circuit and Its Plasticity in Response to Emotional and Physiological Stress
  4. 39924
    “…Increasing availability of transgenic rat models, and the range of established behavioural paradigms, necessitates development of a chronic preparation for the rat. …”
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    Refinement of a chronic cranial window implant in the rat for longitudinal in vivo two–photon fluorescence microscopy of neurovascular function
  5. 39925
    “…Therapeutic modulation of cosignaling pathways may shift paradigms from surgical prevention of recurrence to oncological intervention. …”
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    Harnessing immunotherapy for liver recipients with hepatocellular carcinoma: a review from a transplant oncology perspective
  6. 39926
    “…Although significantly higher quadriceps muscle mass following homotopic nerve grafting was measured, we did not observe differences in gait analysis, and electrophysiological parameters between treatment paradigms. Our study provides evidence for phenotypic commitment of autologous nerve grafts after injury and gives a conclusive overview of temporal expression of several important regeneration-associated genes after repair with sensory or motor graft.…”
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    Spatiotemporal Differences in Gene Expression Between Motor and Sensory Autografts and Their Effect on Femoral Nerve Regeneration in the Rat
  7. 39927
    “…To gain knowledge on the mechanistic interplay between local inflammation and synapse changes, we compared two diverse inflammatory paradigms, a cytokine cocktail (CKs; IL-1β, TNF-α, and GM-CSF) and LPS, and their ability to tune GABAergic current duration in spinal cord cultured circuits. …”
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    Cytokine inflammatory threat, but not LPS one, shortens GABAergic synaptic currents in the mouse spinal cord organotypic cultures
  8. 39928
    “…As predicted by classical community ecology paradigms, and as observed in similar environments, a single species is expected to dominate the phytoplanktonic communities. …”
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    Very Low Phytoplankton Diversity in a Tropical Saline-Alkaline Lake, with Co-dominance of Arthrospira fusiformis (Cyanobacteria) and Picocystis salinarum (Chlorophyta)
  9. 39929
    “…We determined surrogate parameters of pain and general well-being after subarachnoid hemorrhage (SAH), as well as the potential for improvement by different systemic analgesia paradigms. Brain injury was induced by filament perforation to mimic SAH. …”
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    Analgesic treatment limits surrogate parameters for early stress and pain response after experimental subarachnoid hemorrhage
  10. 39930
    “…Research in neuroscience, based on naturalistic paradigms, has shown that abilities to mentalize and to empathize are associated with the activation of different neuro-cognitive circuits. …”
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    Intersections and Divergences Between Empathizing and Mentalizing: Development, Recent Advancements by Neuroimaging and the Future of Animal Modeling
  11. 39931
    “…Contrary to current paradigms on CO oxidation, the enzyme did not support chemolithoautotrophic growth and was dispensable for CO detoxification. …”
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    Atmospheric carbon monoxide oxidation is a widespread mechanism supporting microbial survival
  12. 39932
    “…Remarkably, the cluster pattern identified in the EEG response is very similar to that commonly found in the classic old/new memory retrieval paradigms, suggesting that the recognition of brief, randomly presented, music snippets, draws on similar processes.…”
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    Rapid Brain Responses to Familiar vs. Unfamiliar Music – an EEG and Pupillometry study
  13. 39933
    “…This protocol aims to (1) identify core concepts in the area of screen time and digital media use in children and adolescents (2) map existing research paradigms and screening/measurement tools that serve to underpin and operationalise core concepts and (3) provide an initial step in integrating these findings into a consolidated screening toolkit. …”
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    From ‘screen time’ to the digital level of analysis: protocol for a scoping review of digital media use in children and adolescents
  14. 39934
    “…In emotional Go/No-Go paradigms, we manipulated the intertrial interval and ratios of Go/No-Go trials to account for motor (Experiment 1, N = 31) and cognitive (Experiment 2, N = 29) response inhibition processes. …”
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    Task-irrelevant odours affect both response inhibition and response readiness in fast-paced Go/No-Go task: the case of valence
  15. 39935
    “…Our results demonstrated that gradual estrogen depletion rather than elevation following the stable period of estrogen substitution in OVX rats alleviated OVX-induced mechanical hyperalgesia in a dose-independent manner, and the opposite estrogen increase or decrease paradigms differently regulate the expression of spinal ERs. …”
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    Estrogen modulation of pain perception with a novel 17β-estradiol pretreatment regime in ovariectomized rats
  16. 39936
    “…In view of diverse stroke models and food restriction paradigms, the consequences of undernutrition are poorly understood. …”
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    Neuroprotection Induced by Energy and Protein-Energy Undernutrition Is Phase-Dependent After Focal Cerebral Ischemia in Mice
  17. 39937
    por Kim, Jean, Naclerio, Robert
    Publicado 2020
    “…Questions arise as to the best use of dupilumab in the context of current treatment paradigms, and for which sub-population of the varied heterogeneous endotypes of CRSwNP patients. …”
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    Therapeutic Potential of Dupilumab in the Treatment of Chronic Rhinosinusitis with Nasal Polyps: Evidence to Date
  18. 39938
    por Nichols, Anthony C., Lang, Pencilla, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, de Almeida, John R., Bayley, Andrew, Goldstein, David P., Eskander, Antoine, Husain, Zain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, MacNeil, S. Danielle, Mendez, Adrian, Winquist, Eric, Read, Nancy, Venkatesan, Varagur, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Rajaraman, Murali, Johnson-Obaseki, Stephanie, Eapen, Libni, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, Matthews, T. Wayne, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, Palma, David A.
    Publicado 2020
    “…These two treatment paradigms have different spectrums of toxicity. The goals of this study are to assess the OS of two de-escalation approaches (primary radiotherapy and primary TOS) compared to historical control, and to compare survival, toxicity and quality of life (QOL) profiles between the two approaches. …”
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    Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial
  19. 39939
    “…Greater increases of plasma BDNF were associated with greater cognitive training gains on trained task paradigms, but only when such increases preceded cognitive training (ß = 0.14, 95% CI [0.04, 0.25]). …”
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    Acute increases in brain-derived neurotrophic factor in plasma following physical exercise relates to subsequent learning in older adults
  20. 39940
    “…Cost concerns make it likely that pathogen inactivation will be contemplated by blood operators through the lens of health economics and risk-based decision making, rather than in zero-risk paradigms previously embraced for transfusable products. …”
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    Blood-Borne Pathogens: A Canadian Blood Services Centre for Innovation Symposium
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