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  1. 39961
    “…Thus, CarcSeq is a promising approach to advance cancer risk assessment and carcinogenicity testing practices. Paradigms that should be investigated to advance this strategy for carcinogenicity testing are proposed.…”
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    Quantification of cancer driver mutations in human breast and lung DNA using targeted, error‐corrected CarcSeq
  2. 39962
    “…Genetic modifiers could be implicated, but the study paradigms to successfully address the impact of each single mutation need to be developed.…”
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    Genotype-phenotype correlations in patients with de novo KCNQ2 pathogenic variants
  3. 39963
    “…Routine cell counts, and albumin, immunoglobulin G and neurofilament light chain concentrations in CSF remained unchanged in both paradigms, while several inflammatory proteins became upregulated after acute exercise. …”
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    Differential effects on blood and cerebrospinal fluid immune protein markers and kynurenine pathway metabolites from aerobic physical exercise in healthy subjects
  4. 39964
    “…Wistar Kyoto (WKY) rats are a valuable model of many of the characteristics of MDD and their resistance to selective serotonin reuptake inhibitors (SSRIs) in several behavioral paradigms emulates treatment resistance in clinical populations. …”
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    The Antidepressant-Like Effects of a Clinically Relevant Dose of Ketamine Are Accompanied by Biphasic Alterations in Working Memory in the Wistar Kyoto Rat Model of Depression
  5. 39965
    “…Tracking of eye movements is an established measurement for many types of experimental paradigms. More complex and more prolonged visual stimuli have made algorithmic approaches to eye-movement event classification the most pragmatic option. …”
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    REMoDNaV: robust eye-movement classification for dynamic stimulation
  6. 39966
    “…Conclusion: Overall, the TARGET‐HCC cohort allows for the assessment of patient characteristics and investigation of new treatment paradigms and sequencing with existing agents as well as novel regimens for HCC.…”
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    A Real‐World Observational Cohort of Patients with Hepatocellular Carcinoma: Design and Rationale for TARGET‐HCC
  7. 39967
    “…Here we discuss refinement of pain-PD paradigms in order that future studies may enhance confidence in the validity of observed effect sizes while also aiding comparability through standardisation. …”
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    Towards optimising experimental quantification of persistent pain in Parkinson’s disease using psychophysical testing
  8. 39968
    “…The aim of the present study was to investigate whether the facial expression of pain is sensitive enough to capture endogenous pain inhibition as elicited during CPM paradigms. PATIENTS AND METHODS: In total, 26 female participants took part in this study. …”
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    Conditioned Pain Modulation (CPM) Effects Captured in Facial Expressions
  9. 39969
    “…Combined with machine learning (ML), this MALDI-TOF-MS approach could overcome logistical barriers encountered by current testing paradigms. We evaluated the analytical performance of an ML-enhanced MALDI-TOF-MS method for screening COVID-19. …”
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    Novel application of automated machine learning with MALDI-TOF-MS for rapid high-throughput screening of COVID-19: a proof of concept
  10. 39970
    “…We argue that these inconsistent findings could be driven by a lack of control over the error frequency in traditional EL and TEL paradigms. AIM: This study employed a spatial learning task to study EL and TEL and to determine the impact of error frequency on memory recall in healthy older adults (OA; N = 68) and young adults (YA; N = 60). …”
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    Prevention is better than cure: effects of errors on memory performance during spatial learning in healthy aging
  11. 39971
    “…This reality brings about the need to change paradigms to consistently and systematically boost cardiovascular prevention as the most cost-effective medium- to long-term strategy to reduce their prevalence in medium- and low-resource countries, not only in Latin America but also in other global regions. …”
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    Considerations and Guidance for the Structure, Organisation, and Operation of Cardiometabolic Prevention Units: A Consensus Statement of the Inter-American Society of Cardiology
  12. 39972
    “…It has been shown that VLPF neurons can show visual responses during paradigms requiring to associate arbitrary visual cues to behavioral reactions. …”
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    Visual response of ventrolateral prefrontal neurons and their behavior-related modulation
  13. 39973
    “…Disease stability over time and response to neoadjuvant therapy may be the best predictors for successful patient outcomes and can be easily incorporated in our treatment paradigms. Current data evaluating liver transplantation for expanded oncologic indications such as: expanded criteria hepatocellular carcinoma, intrahepatic cholangiocarcinoma, mixed tumors, and liver limited metastatic colorectal carcinomas, incorporate multi-modal therapies and evaluation of tumor treatment response. …”
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    Expanding indications for liver transplantation in the era of liver transplant oncology
  14. 39974
    “…Radical new paradigms are needed to equip non-professionals and leverage community faith-based infrastructure to address the individual and communal wounds of war- and conflict-related trauma. …”
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    Reaching the Unreached: Bridging Islam and Science to Treat the Mental Wounds of War
  15. 39975
    “…We developed a novel task in which participants were required to search static and moving displays for an orientation change thus capturing components of visual search, multiple object tracking and change detection paradigms. In Experiment 1, we found that the addition of moving distractors slowed participants’ response time to detect an orientation changes in a moving target, showing that the motion of distractors disrupts the rapid detection of orientation changes in a moving target. …”
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    Motion disrupts dynamic visual search for an orientation change
  16. 39976
    “…This hypothesis will require future testing through a range of experimental paradigms, and if upheld, complement and coagulation pathways or specific proteins could be useful diagnostic or prognostic tools and targets for early intervention and preventive strategies.…”
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    Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis
  17. 39977
    por Das, William, Khanna, Shubh
    Publicado 2021
    “…This study is the first to apply machine learning based methods for the detection of ADHD using solely pupillometrics, and highlights its strength as a potential discriminative biomarker, paving the path for the development of novel diagnostic applications to aid in the detection of ADHD using oculometric paradigms and machine learning.…”
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    A Robust Machine Learning Based Framework for the Automated Detection of ADHD Using Pupillometric Biomarkers and Time Series Analysis
  18. 39978
    “…Acute and repeated nicotine vapor exposure did not alter body weight, and both exposure paradigms produced pharmacologically significant serum nicotine and cotinine levels in the 120 mg/ml nicotine group compared with PG/VG controls. …”
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    Electronic Nicotine Vapor Exposure Produces Differential Changes in Central Amygdala Neuronal Activity, Thermoregulation and Locomotor Behavior in Male Mice
  19. 39979
    “…We aimed to analyze the effect of the diurnal variations in traffic rates at weekdays and weekends on the catchment area size of three transportation paradigms, i.e. mothership, drip-and-ship (DS) and drip-and-drive (DD). …”
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    Modeling the Optimal Transportation for Acute Stroke Treatment: Impact of Diurnal Variations in Traffic Rate
  20. 39980
    por Manna, Raffaele, Rigante, Donato
    Publicado 2021
    “…The description focuses inflammasomopathies as paradigms of interleukinopathies, nuclear factor-κB -related disorders and interferonopathies. …”
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    The everchanging framework of autoinflammation
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