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  1. 40041
    “…We then examined, using ZIP, the effect of PKMζ inhibition in dorsal hippocampus (DH) and basolateral amygdala (BLA) on retention of 1-d-old information acquired in the radial arm maze, water maze, inhibitory avoidance, and contextual and cued fear conditioning paradigms. In the DH, PKMζ inhibition selectively disrupted retention of information for spatial reference, but not spatial working memory in the radial arm maze, and precise, but not coarse spatial information in the water maze. …”
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    PKMζ Maintains Spatial, Instrumental, and Classically Conditioned Long-Term Memories
  2. 40042
    “…A method of exploiting HPC systems, using R, but without recourse to mastering parallel programming paradigms is therefore necessary to analyse genomic data to its fullest. …”
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    SPRINT: A new parallel framework for R
  3. 40043
    “…However, the continuous stimulation characteristic of EA treatment presents challenges to the use of conventional functional Magnetic Resonance Imaging (fMRI) approaches for the investigation of neural mechanisms mediating treatment response because of the requirement for brief and intermittent stimuli in event related or block designed task paradigms. A relatively new analysis method, functional connectivity fMRI (fcMRI), has great potential for studying continuous treatment modalities such as EA. …”
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    Imaging the functional connectivity of the Periaqueductal Gray during genuine and sham electroacupuncture treatment
  4. 40044
    “…Our contention is that these paradigms were not well suited to dissociating processing within the two streams. …”
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    Online Artículo Texto
    “What” and “Where” in Auditory Sensory Processing: A High-Density Electrical Mapping Study of Distinct Neural Processes Underlying Sound Object Recognition and Sound Localization
  5. 40045
    “…Animals were then tested in different anxiety-related paradigms for emotional reactivity [e.g., elevated plus maze (EPM), light/dark emergence test (EMT), social interaction] and the attentional set shift task (ASST) – an adaptation of the human Wisconsin card sorting test – for cognitive abilities and behavioral flexibility. …”
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    AAV-Mediated Overexpression of the CB1 Receptor in the mPFC of Adult Rats Alters Cognitive Flexibility, Social Behavior, and Emotional Reactivity
  6. 40046
    “…In another domain of study, the analysis of rat put USVs has been conducted via paradigms that allow for better experimental control over correlated prenatal conditions that may confound findings and conclusions regarding the effects of specific prenatal experiences. …”
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    Development of Translational Methods in Spectral Analysis of Human Infant Crying and Rat Pup Ultrasonic Vocalizations for Early Neurobehavioral Assessment
  7. 40047
    “…In primary MM cells, PI-103 enhanced the anti-proliferative effects of anti-MM agents. Treatment paradigms including blockade of the PI3K/mTOR pathway should be targeted at patients with IgH translocations associated with cyclin D2 overexpression.…”
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    Inhibition of cell cycle progression by dual phosphatidylinositol-3-kinase and mTOR blockade in cyclin D2 positive multiple myeloma bearing IgH translocations
  8. 40048
    “…BACKGROUND: Centenarians are exceptional ageing paradigms, offering valuable information on achieving longevity. …”
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    Gender differences in Greek centenarians. A cross-sectional nation-wide study, examining multiple socio-demographic and personality factors and health locus of control
  9. 40049
    “…In a cross-species translational study, thirty rats were trained in impulsive choice (delayed reward task) and impulsive action (five-choice serial reaction time task) paradigms. The correlation between those measures was assessed during baseline performance and after pharmacological manipulations with the psychostimulant amphetamine and the norepinephrine reuptake inhibitor atomoxetine. …”
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    The Relationship between Impulsive Choice and Impulsive Action: A Cross-Species Translational Study
  10. 40050
    “…Taken as a whole, these results show that that the anticonvulsant effect of brainstem activation can be efficiently utilized by reactive triggering, which suggests that alternative stimulation paradigms for vagus nerve stimulation might be useful. …”
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    Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish
  11. 40051
    “…These results could shift current paradigms of antihistamine utilization from a predominantly-systemic to a topical approach.…”
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    TOPICAL ANTIHISTAMINES DISPLAY POTENT ANTI-INFLAMMATORY ACTIVITY LINKED IN PART TO ENHANCED PERMEABILITY BARRIER FUNCTION
  12. 40052
    “…Here, we re-evaluate the role of experience-dependent neuronal activity on barrel expansion in birth-enucleated rats by combining various anatomical methods and sensory deprivation paradigms. We show that barrels in birth-enucleated rats were already enlarged by the end of the first week of life and had levels of metabolic activity comparable to those in control rats at different ages. …”
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    Shifts in Developmental Timing, and Not Increased Levels of Experience-Dependent Neuronal Activity, Promote Barrel Expansion in the Primary Somatosensory Cortex of Rats Enucleated at Birth
  13. 40053
    “…BACKGROUND: In research on theory of mind (ToM), false belief paradigms are commonly used. Previous studies have reported that there is heterogeneity in the magnitude of impairment on false belief tasks. …”
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    Dissociation of understanding from applying others’ false beliefs in remitted schizophrenia: evidence from a computerized referential communication task
  14. 40054
    “…Thus, combined rTMS-ERP approaches need to be further established in order to serve as paradigms in experimental neuroscience and clinical research.…”
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    Effects of Low Frequency Prefrontal Repetitive Transcranial Magnetic Stimulation on the N2 Amplitude in a GoNogo Task
  15. 40055
    “…Here we address some of the difficulties in experimental design when investigating alternative splicing of VEGF isoforms, and discuss the use of appropriate control paradigms. We demonstrate why use of specific control experiments can prevent assumptions that VEGF-A(165)b is not present, when in fact it is. …”
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    Detection of VEGF-A(xxx)b Isoforms in Human Tissues
  16. 40056
    “…Future studies aimed at exploring fNIRS differences in various clinical stages, longitudinal changes, drug effects, and variations during different task paradigms will be needed to develop more accurate biomarkers that can be used to aid differential diagnosis, the comprehension of the present condition, the prediction of outcome, and the decision regarding treatment options in schizophrenia. …”
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    Near-Infrared Spectroscopy in Schizophrenia: A Possible Biomarker for Predicting Clinical Outcome and Treatment Response
  17. 40057
    “…The study deliberately partnered with student leaders and centralised social, cultural, and religious paradigms. Student leaders were interviewed about their experience of partnering in sensitive health research. …”
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    Researching male circumcision for HIV prevention in Papua New Guinea: a process that incorporates science, faith and culture
  18. 40058
    “…Comparative studies of fibroblasts from affected, carriers and controls, under different paradigms of metabolic demand, show that carriers display the highest capacity for activating mitochondrial biogenesis. …”
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    Efficient mitochondrial biogenesis drives incomplete penetrance in Leber’s hereditary optic neuropathy
  19. 40059
    “…BACKGROUND: The annual incidence of a small indeterminate pulmonary nodule (IPN) on computed tomography (CT) scan remains high. While traditional paradigms exist, the integration of new technologies into these diagnostic and treatment algorithms can result in alternative, potentially more efficient methods of managing these findings. …”
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    Thoracoscopic detection of occult indeterminate pulmonary nodules using bronchoscopic pleural dye marking
  20. 40060
    “…Reassessment of optimal management paradigms for patients hospitalized with CAP may be warranted.…”
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    Resource use by patients hospitalized with community-acquired pneumonia in Europe: analysis of the REACH study
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