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  1. 40081
    “…METHODS: Two stimulation paradigms were applied: a) painful pressure stimulation at the dorsal forearm; b) verbal fluency test (VFT). …”
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    Increased cortical activation upon painful stimulation in fibromyalgia syndrome
  2. 40082
    “…The lack of a role of Hfq in the E. coli GFP-based system indicates that the CjNC1 and CjNC4 ncRNAs may mediate post-transcriptional gene regulation in ways that do not conform to the paradigms obtained from the Enterobacteriaceae.…”
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    Conservation of σ(28)-Dependent Non-Coding RNA Paralogs and Predicted σ(54)-Dependent Targets in Thermophilic Campylobacter Species
  3. 40083
    “…Methods: Twenty-eight subjects participated in adapted go/nogo paradigms, including a voluntary selection condition allowing participants to (1) freely decide whether to press the response button or (2) to decide whether they wanted to press the response button with the right index finger or the left index finger. …”
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    Increased Event-Related Potentials and Alpha-, Beta-, and Gamma-Activity Associated with Intentional Actions
  4. 40084
    “…METHODS: C57BL/6J mice with heterozygous and homozygous disruption of Cntn4 were studied through an extensive, partially longitudinal, test battery at various developmental stages, including various paradigms testing social and restricted repetitive behaviors. …”
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    Limited impact of Cntn4 mutation on autism-related traits in developing and adult C57BL/6J mice
  5. 40085
    “…Nuciferine was then tested in vivo in the head-twitch response, pre-pulse inhibition, hyperlocomotor activity, and drug discrimination paradigms. RESULTS: Nuciferine shares a receptor profile similar to aripiprazole-like antipsychotic drugs. …”
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    In Vitro and In Vivo Characterization of the Alkaloid Nuciferine
  6. 40086
    “…The default mode network (DMN) is a set of regions that is tonically engaged during the resting state and exhibits task-related deactivation that is readily reproducible across a wide range of paradigms and modalities. The DMN has been implicated in numerous disorders of cognition and, in particular, in disorders exhibiting age-related cognitive decline. …”
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    Progressive Bidirectional Age-Related Changes in Default Mode Network Effective Connectivity across Six Decades
  7. 40087
    “…We therefore combined [(18)F]fluoro-2-deoxyglucose positron-emission-tomography (FDG-PET) with PPI and resting state control paradigms in awake rats. A battery of subtractive, correlative as well as seed-based functional connectivity analyses revealed a default mode-like network (DMN) active during resting state only. …”
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    The Functional Networks of Prepulse Inhibition: Neuronal Connectivity Analysis Based on FDG-PET in Awake and Unrestrained Rats
  8. 40088
    “…We propose that the beneficiaries of palliative psychiatry are patients with severe persistent mental illness, who are at risk of therapeutic neglect and/or overly aggressive care within current paradigms. These include long-term residential care patients with severe chronic schizophrenia and insufficient quality of life, those with therapy-refractory depressions and repeated suicide attempts, and those with severe long-standing therapy-refractory anorexia nervosa. …”
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    Palliative psychiatry for severe persistent mental illness as a new approach to psychiatry? Definition, scope, benefits, and risks
  9. 40089
    “…Refractoriness of glioblastoma multiforme (GBM) to current treatment paradigms has necessitated identification of new targets to better the existing therapeutic strategies. …”
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    PPARγ regulated CIDEA affects pro-apoptotic responses in glioblastoma
  10. 40090
    “…The aim of the current study is to determine specific boundary conditions in order to consistently degrade motor memory through reconsolidation paradigms. We investigated a sequence tapping task (n = 48) with the typical three-day design and confirmed that reactivating the motor sequence briefly (10 times tapping the learned motor sequence) destabilizes the memory trace and makes it susceptible to behavioral interference. …”
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    Reconsolidation of Motor Memories Is a Time-Dependent Process
  11. 40091
    “…Healthy controls were the fastest in all paradigms and cognitively mildly impaired had higher DTC than depressed individuals. …”
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    Dual Tasking for the Differentiation between Depression and Mild Cognitive Impairment
  12. 40092
    “…We exposed BAC-transgenic D1-tomato and D2-eGFP mice to PD and dyskinesia model paradigms, enabling cell type-specific assessment of changes in synaptic physiology and morphology. …”
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    L-DOPA Oppositely Regulates Synaptic Strength and Spine Morphology in D1 and D2 Striatal Projection Neurons in Dyskinesia
  13. 40093
    “…CONCLUSION: Modified approaches or alternative paradigms to establish the ‘value for money’ conferred by interventions for URDs should be developed with high priority.…”
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    Determining the value of medical technologies to treat ultra-rare disorders: a consensus statement
  14. 40094
    “…CONCLUSIONS: By demonstrating increased false-positive diagnoses when reducing the stringency of predicting an abnormality, these data illustrate the importance of preclinical evaluation of new testing paradigms before clinical implementation.…”
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    A randomized and blinded comparison of qPCR and NGS-based detection of aneuploidy in a cell line mixture model of blastocyst biopsy mosaicism
  15. 40095
    “…The pharmacokinetic paradigms of lanthanum and aluminium are different in that lanthanum is minimally absorbed and eliminated via the hepatobiliary pathway, whereas aluminium shows appreciable absorption and is eliminated by the kidneys. …”
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    Lanthanum carbonate: safety data after 10 years
  16. 40096
    “…To attain this type of regeneration, rehabilitation paradigms that pair cortically-based intent with activation of affected circuits and positive neurofeedback appear to be required—a phenomenon which raises new and far reaching questions about the underlying relationship between conscious action and neural repair. …”
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    Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation
  17. 40097
    “…Although the patient-centered approach accentuating self-management is one of the dominant paradigms in modern medicine, our observations show several influencing determinants causing difficulties in daily practice implementation. …”
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    Barriers and facilitators influencing self-management among COPD patients: a mixed methods exploration in primary and affiliated specialist care
  18. 40098
    “…Statin add‐on therapies, such as ezetimibe and the recently approved proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors alirocumab and evolocumab, allow patients to achieve very low LDL‐C levels and are likely to impact on future treatment paradigms.…”
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    Very low LDL‐C levels may safely provide additional clinical cardiovascular benefit: the evidence to date
  19. 40099
    “…Auditory selective attention paradigms are powerful tools for elucidating the various stages of speech processing. …”
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    Intracranial Electrophysiology of Auditory Selective Attention Associated with Speech Classification Tasks
  20. 40100
    “…We will develop an analysis plan, first using traditional univariate and multivariable analytical paradigms with independent, dependent and mediating/confounding/interacting variables to test the main hypotheses. …”
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    Birth size, risk factors across life and cognition in late life: protocol of prospective longitudinal follow-up of the MYNAH (MYsore studies of Natal effects on Ageing and Health) cohort
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