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40121“…Furthermore, these observations indicate that continuous paradigms such as the one we have used can push humans to make remarkably fast reaction times that impose strong constraints and challenges on models of how, where, and when visual processing occurs in the human brain.…”
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40122“…We irradiated young adult mice wild type (+/+) or knockout (−/−) of the Cdkn1a (p21) gene, and used different bromodeoxyuridine (BrdU) paradigms for cell fate mapping. The acute apoptotic response of NPCs in the subgranular zone of the dentate gyrus was independent of p21 after irradiation. …”
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40123por Alvin, Matthew D., Lubelski, Daniel, Alam, Ridwan, Williams, Seth K., Obuchowski, Nancy A., Steinmetz, Michael P., Wang, Jeffrey C., Melillo, Alfred J., Pahwa, Amit, Benzel, Edward C., Modic, Michael T., Quencer, Robert, Mroz, Thomas E.“…CONCLUSIONS: Significant variability in surgical treatment paradigms exists for different pathologies. Understanding why variability in treatment selection exists in similar clinical contexts across practices is important to ensure the most cost-effective delivery of care among spine surgeons.…”
Publicado 2017
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40124por Hummel, E. M., Hessas, E., Müller, S., Beiter, T., Fisch, M., Eibl, A., Wolf, O. T., Giebel, B., Platen, P., Kumsta, R., Moser, D. A.“…Interestingly, cell-free mitochondrial DNA showed similar increase after both stress paradigms. Furthermore, cfDNA methylation signatures—used here as a marker for diverse cellular origin—were significantly different post stress tests. …”
Publicado 2018
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40125por Rothrock, Michael J., Feye, Kristina M., Kim, Sun Ae, Park, Si Hong, Locatelli, Aude, Hiett, Kelli L., Gamble, John, Sellers, Holly, Ricke, Steven C.“…Therefore, current monitoring paradigms are not comprehensive because they fail to capture the presence of invasive pathogens within the embryonic GIT rapidly. …”
Publicado 2018
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40126por Schoberleitner, Ines, Mutti, Anna, Sah, Anupam, Wille, Alexandra, Gimeno-Valiente, Francisco, Piatti, Paolo, Kharitonova, Maria, Torres, Luis, López-Rodas, Gerardo, Liu, Jeffrey J., Singewald, Nicolas, Schwarzer, Christoph, Lusser, Alexandra“…Here we present data that implicate the highly conserved chromatin assembly and remodeling factor Chd1 in memory formation and the control of immediate early gene (IEG) response in the hippocampus. We used various paradigms to assess short-and long-term memory in mice bearing a mutated Chd1 gene that gives rise to an N-terminally truncated protein. …”
Publicado 2019
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40127por Armao, Diane, Bouldin, Thomas W., Bailey, Rachel M., Hooper, Jody E., Bharucha, Diana X., Gray, Steven J.“…Similar IF inclusion bodies in lens epithelial cells have not been reported previously in experimental animal models or human diseases. Since current paradigms in drug discovery and drug repurposing for IF-associated disorders are often hindered by lack of validated targets, our findings suggest that lens epithelial cells in the GAN KO mouse may provide a potential target, in vivo and in vitro, for evaluating drug efficacy and alternative therapeutic approaches in promoting the clearance of IF inclusions in GAN and other diseases characterized by intracellular IF accumulations. …”
Publicado 2019
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40128“…CONCLUSION: In the present research work, SNL (5, 10, and 15 mg/kg p.o.) provided notable neuroprotective effect, which was confirmed by behavioral paradigms and biochemical test. It restored the behavioral and biochemical alteration caused by 3-NP and confirmed the strong neuroprotective mechanism of SNL in 3-NP-intoxicated memory and cognitive abnormalities.…”
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40129por Steen, Richard, Hontelez, Jan A.C., Mugurungi, Owen, Mpofu, Amon, Matthijsse, Suzette M., de Vlas, Sake J., Dallabetta, Gina A., Cowan, Frances M.“…Potential biases related to changing epidemic paradigms and data sources were examined. RESULTS: Early studies describe rural poverty, male migrant labour and sex work as conditions facilitating HIV/sexually transmitted infection (STI) transmission. …”
Publicado 2019
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40130por Caron, Patrick, Ferrero y de Loma-Osorio, Gabriel, Nabarro, David, Hainzelin, Etienne, Guillou, Marion, Andersen, Inger, Arnold, Tom, Astralaga, Margarita, Beukeboom, Marcel, Bickersteth, Sam, Bwalya, Martin, Caballero, Paula, Campbell, Bruce M., Divine, Ntiokam, Fan, Shenggen, Frick, Martin, Friis, Anette, Gallagher, Martin, Halkin, Jean-Pierre, Hanson, Craig, Lasbennes, Florence, Ribera, Teresa, Rockstrom, Johan, Schuepbach, Marlen, Steer, Andrew, Tutwiler, Ann, Verburg, Gerda“…This calls for deep changes in comparison with the paradigms that prevailed when steering the agricultural change in the XXth century. …”
Publicado 2018
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40131por King, Regan, Kirton, Adam, Zewdie, Ephrem, Seeger, Trevor A., Ciechanski, Patrick, Barlow, Karen M.“…Cortical excitability was measured using TMS paradigms at 1 and 2 months post injury. The primary outcome was the cortical silent period (cSP). …”
Publicado 2019
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40132por Berger, Alisa, Horst, Fabian, Müller, Sophia, Steinberg, Fabian, Doppelmayr, Michael“…Based on comparable studies using fused EEG-fNIRS integrations either for guiding non-invasive brain stimulation or as part of brain-machine interface paradigms, the potential of this methodologically combined approach in RAGT is discussed. …”
Publicado 2019
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40133por Dyson, Jessica K., Wong, Lin Lee, Bigirumurame, Theophile, Hirschfield, Gideon M., Kendrick, Stuart, Oo, Ye H., Lohse, Ansgar W, Heneghan, Michael A., Jones, David E. J.“…BACKGROUND: Treatment paradigms in autoimmune hepatitis (AIH) have remained largely unchanged for decades. …”
Publicado 2018
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40134por Sartirana, Marco“…BACKGROUND: The involvement of doctors in managerial roles seems to be the solution to reducing the friction between traditional professionalism and modern organizational paradigms. However, these “hybrid” professionals responded in different ways to these conflicting demands, and we need to better understand the contextual factors that explain such variation. …”
Publicado 2019
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40135por Etter, Meghan, Goose, Annie, Nossal, Margot, Chishom‐Nelson, Jessica, Heck, Carly, Joober, Ridha, Boksa, Patricia, Lal, Shalini, Shah, Jai L., Andersson, Neil, Iyer, Srividya N., Malla, Ashok“…CONCLUSIONS: Information from service providers, youth and other community members demonstrates attuning of the ACCESS OM framework to Inuit paradigms in Ulukhaktok. It could prove to be a sustainable prototype for delivering youth mental health services in other communities in the Inuvialuit Settlement Region and possibly across the entire Inuit Nunangat. …”
Publicado 2019
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40136por Marwari, Subhi, Poulsen, Anders, Shih, Norrapat, Lakshminarayanan, Rajamani, Kini, R. Manjunatha, Johannes, Charles William, Dymock, Brian William, Dawe, Gavin Stewart“…Further, intranasal administration of the lead i,i+7 stapled peptide exerted anxiolytic and antidepressant‐like activity in anxiety‐ and depression‐related behaviour paradigms. CONCLUSIONS AND IMPLICATIONS: Our preclinical findings demonstrate that targeting the relaxin‐3/RXFP3 receptor system via intranasal delivery of an i,i+7 stapled relaxin‐3 mimetic may represent an effective treatment approach for depression, anxiety, and related neuropsychiatric disorders.…”
Publicado 2019
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40137“…Motor abilities of the animals were examined using open-field, rotarod running, and beam-walking behavioral paradigms. Vital molecules of Wnt signaling were detected, and the involvement of such molecules was verified using in vitro culture of OPCs. …”
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40138por Trimmel, Karin, van Graan, Louis A., Gonzálvez, Gloria G., Haag, Anja, Caciagli, Lorenzo, Vos, Sjoerd B., Bonelli, Silvia, Sidhu, Meneka, Thompson, Pamela J., Koepp, Matthias J., Duncan, John S.“…METHODS: Forty‐six patients with TLE (25 left) and 19 controls underwent two overt fMRI paradigms (auditory naming and picture naming, both with active baseline conditions) and one covert task (verbal fluency). …”
Publicado 2019
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40139por Mansouri, Farrokh, Shanbour, Alaa, Mazza, Frank, Fettes, Peter, Zariffa, José, Downar, Jonathan“…While stimulation effects were not apparent in this study, the nominal performance of the phase-locking algorithm offers a technical foundation for further research in determining effective stimulation paradigms and conditions. Specifically, future work should investigate stronger stimulation and true task-specific stimulation of SN nodes responsible for the task as well as their recording. …”
Publicado 2019
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40140por Assiri, Mohammed A., Ali, Hadi R., Marentette, John O., Yun, Youngho, Liu, Juan, Hirschey, Matthew D., Saba, Laura M., Harris, Peter S., Fritz, Kristofer S.“…Overall, our data suggest further research is needed to fully characterize treatment paradigms and biochemical implications of NAD(+)-based interventions.…”
Publicado 2019
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