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  1. 40661
    “…Integrating NEE-CRF into screening paradigms and referring low-fit individuals to improve CRF could complement the public health prevention strategy against cancer.…”
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    Non-exercise estimated cardiorespiratory fitness and cancer incidence: The NIH-AARP diet and health study
  2. 40662
    “…Cross-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inhibition of nerve repair in in vitro and in vivo paradigms of axon regeneration. These effects involve the activation of the small GTPase RhoA/ROCK signaling pathways, which negatively modulate growth cone cytoskeleton, similarly to well stablished inhibitors of axon regeneration described so far. …”
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    Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies
  3. 40663
    “…The effects of allelic variations in the MC4R gene on cAMP synthesis, MC4R protein level, and activation of PKA, ERB, and CREB signaling pathways in both stimulated and unstimulated ɑ-MSH paradigms were determined for their functional implications. …”
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    Functional Characterization of Novel MC4R Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar
  4. 40664
    por Ede, Thomas, Parsons, Thomas D.
    Publicado 2023
    “…The numerous different combinations of experimental paradigms and welfare interventions reported in the literature creates challenges for a critical meta-analysis of the field especially in evaluating the efficiency of specific cognitive tasks in assessing animal welfare. …”
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    Cognitive tasks as measures of pig welfare: a systematic review
  5. 40665
    “…To validate our results, we tested APPEAR on EEG data recorded from healthy control subjects during resting-state (n = 48) and task-based (i.e. event-related-potentials (ERPs); n = 8) paradigms. The chosen gold standard is an expert manual review of the EEG database. …”
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    Automated pipeline for EEG artifact reduction (APPEAR) recorded during fMRI
  6. 40666
    por Howe, Charles L
    Publicado 2005
    “…CONCLUSION: Our model suggests that cells might utilize two distinct information transmission paradigms: 1) fast local signaling via diffusion over spatial domains on the order of less than 200 nanometers; 2) long-distance signaling via information packets associated with the cytoskeletal transport apparatus. …”
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    Modeling the signaling endosome hypothesis: Why a drive to the nucleus is better than a (random) walk
  7. 40667
    “…Hence, we developed experimental paradigms to determine the influence of prolactin on sexual behaviour and prostate organization of male rats. …”
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    Prostate response to prolactin in sexually active male rats
  8. 40668
    “…In order to develop complex and well-controlled fMRI paradigms, interfaces that can precisely control and measure output force and kinematics of the movements in human subjects are needed. …”
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    fMRI-compatible rehabilitation hand device
  9. 40669
    “…Taking advantage of the peculiar behavioral pattern of copulating male rats, we developed experimental paradigms to determine the influence of sexual behavior on the level of serum testosterone, prostate androgen receptors, and mRNA for androgen receptors in male rats displaying up to four consecutive ejaculations. …”
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    A study of the prostate, androgens and sexual activity of male rats
  10. 40670
    “…Our aim was to investigate whether working memory deficits may be detected across different paradigms using the self-ordered pointing task (SOPT) and the visual conditional associative learning task (VCALT) in patients with schizophrenia spectrum disorders and healthy controls. …”
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    Self-ordered pointing and visual conditional associative learning tasks in drug-free schizophrenia spectrum disorder patients
  11. 40671
    “…The results reveal that Ca(V)β SH3 and GK domains function codependently to tune Ca(2+) channel trafficking and gating properties, and suggest new paradigms for physiological and therapeutic regulation of Ca(2+) channel activity.…”
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    A Ca(V)β SH3/Guanylate Kinase Domain Interaction Regulates Multiple Properties of Voltage-gated Ca(2+) Channels
  12. 40672
    “…Twelve patients received vinorelbine, given as two 25 mg/m(2 )doses on day 1 and 8, and cisplatin, given as a 75 mg/m(2 )dose on day 1. Both treatment paradigms were repeated on a 21-day cycle. Tumor response was evaluated by comparing tumor size on computerized tomography scans before and after three cycles of chemotherapy. …”
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    The effect of HER2 expression on cisplatin-based chemotherapy in advanced non-small cell lung cancer patients
  13. 40673
    “…Therefore, various visualization paradigms have been established during the last years. …”
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    Visualizing post genomics data-sets on customized pathway maps by ProMeTra – aeration-dependent gene expression and metabolism of Corynebacterium glutamicum as an example
  14. 40674
    “…CONCLUSION: The complex pattern of links between diverse characteristics and the lack of a single dominant factor suggests a need for multifactorial and multidisciplinary paradigms for the research, treatment and prevention of diabetic complications.…”
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    Network of vascular diseases, death and biochemical characteristics in a set of 4,197 patients with type 1 diabetes (The FinnDiane Study)
  15. 40675
    por Na, Dokyun, Lee, Sunjae, Lee, Doheon
    Publicado 2010
    “…BACKGROUND: Within the emerging field of synthetic biology, engineering paradigms have recently been used to design biological systems with novel functionalities. …”
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    Mathematical modeling of translation initiation for the estimation of its efficiency to computationally design mRNA sequences with desired expression levels in prokaryotes
  16. 40676
    por Bremel, Robert D, Homan, E Jane
    Publicado 2010
    “…CONCLUSIONS: As opposed to the highly constrained user-interaction paradigms of web-server approaches, local computational approaches enable interactive analysis and visualization of complex multidimensional data using robust mathematical tools. …”
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    An integrated approach to epitope analysis I: Dimensional reduction, visualization and prediction of MHC binding using amino acid principal components and regression approaches
  17. 40677
    “…BACKGROUND: Stroke rehabilitation with different exercise paradigms has been investigated, but which one is more effective in facilitating motor recovery and up-regulating brain neurotrophic factor (BDNF) after brain ischemia would be interesting to clinicians and patients. …”
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    The Effects of Voluntary, Involuntary, and Forced Exercises on Brain-Derived Neurotrophic Factor and Motor Function Recovery: A Rat Brain Ischemia Model
  18. 40678
    “…The toolkit will integrate theoretical models and new measurement paradigms as well as building on social marketing approaches around consumer segmentation. …”
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    Development of strategies for effective communication of food risks and benefits across Europe: Design and conceptual framework of the FoodRisC project
  19. 40679
    “…We use a slippery surface setup to investigate the timing of leg muscles in the behaving stick insect with respect to touch-down and lift-off under different behavioral paradigms such as straight forward and curved walking in intact and reduced preparations.…”
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    Studying the Neural Basis of Adaptive Locomotor Behavior in Insects
  20. 40680
    “…The improved understanding of the disease and advances in molecular biology is changing the treatment paradigms from Chang's staging system to molecular risk stratification. …”
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    Medulloblastoma in childhood-King Edward Memorial hospital surgical experience and review: Comparative analysis of the case series of 365 patients
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