“…By highlighting new paradigms in the role of the stromal compartment in PDAC therapy, we hope to stimulate new concepts aimed at improving patient outcomes.…”
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“…Furthermore, we justify our customized CNN model by extensively comparing it with widely adopted CNN architectures in the literature, namely ResNet, Inception-ResNet v2, and DenseNet that represent depth-based, multi-path-based, and hybrid CNN paradigms. The encouragingly high classification accuracy of our proposal implies that it can efficiently automate COVID-19 detection from radiograph images to provide a fast and reliable evidence of COVID-19 infection in the lung that can complement existing COVID-19 diagnostics modalities.…”
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“…The second analytical method involved in-depth human coding of a subset of positive education abstracts (n=2,805) by a team of five researchers to identify trends pertaining to how positive education research has been conducted in terms of paradigms, designs, methods, tools, samples, and settings from 1950 to 2016. …”
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“…Our results show the limitations of current paradigms recommended by the international nutrition community. …”
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“…To elucidate mechanisms underlying the role of the PSD95-nNOS-NO pathway in conditioned fear, here we use rodent behavioral paradigms, pharmacological treatment with a small molecular PSD95-nNOS inhibitor, co-immunoprecipitation, Western blotting, and RNA-sequencing. …”
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“…To elucidate mechanisms underlying the role of the PSD95-nNOS-NO pathway in conditioned fear, here we use rodent behavioral paradigms, pharmacological treatment with a small molecule PSD95-nNOS inhibitor, RNA-sequencing, and an AAV-mediated knockdown of the nNOS gene in the BLA. …”
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“…Currently, age and diagnosis determine referral to pediatric or adult oncology, with differing treatment paradigms and service utilization patterns, contributing to suboptimal improvements in outcomes. …”
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“…The tropical diseases caused by protozoan parasites lack combinatorial drug targets as effective paradigms. Targeting signaling mechanisms operative in these pathogens can provide greater molecules in combatting their infections.…”
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“…The obtained results illustrate the feasibility of combining multiple techniques for multimodal monitoring and thereby provide, for the first time, a direct comparison between the changes in KF network organization at the single filament level and local force distribution in defined paradigms.…”
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“…Future translational research evaluating therapeutic benefits should consider in vitro studies, active vs. passive stretching, shorter-term vs. longer-term interventions, systemic vs. local effects of stretching, animal models resembling human anatomy, control and estimation of non-specific stresses, development of in vivo self-stretching paradigms targeting myofascial tissues, and in vivo models accounting for gross musculoskeletal posture.…”
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“…The model does not account for disruptions in care or other commonly used treatment paradigms, which may lead to differences in estimated economic return. …”
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“…In the past 2 decades, zebrafish has been used to study the complex effects of ethanol on the vertebrate brain and behavior in both acute, chronic and developmental exposure paradigms. Sex differences in the neurobehavioral response to ethanol are well documented for humans and rodents, yet no consensus has been reached for zebrafish. …”
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“…Interventional clinical trials in glioblastoma (GBM) have been consistently disappointing, attributable to various factors such as ineffective therapies, inadequate trial designs including lack of control arms, or enrollment criteria that do not represent real-world practice. Novel paradigms for clinical trial design(s) in GBM are desperately needed to produce clinically useful patient outcomes. …”
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“…Since the encoding of hand movements in pointing paradigms is side-dependent, the choice of right vs. left hand for pointing during R-PA may influence the visuomotor adaptation process and hence the reshaping of the attentional system. …”
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“…Three significant areas for future research on post stroke fall risk assessment have been identified: 1) further exploration the efficacy of quantitative detailed motion analysis; 2) implementation of inertial measurement units as a cost-effective and accessible tool in clinics and beyond; and 3) investigation of the capability of cognitive-motor dual-task paradigms and their association with FRFs.…”
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“…We aimed to determine differences between the DS and DC paradigms after EVT of acute stroke patients with large-vessel-occlusion (LVO) in the database of the German Stroke Registry (GSR). …”
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“…Initial treatments informed by patient‐reported data could lead to more successful outcomes by changes in treatment paradigms.…”
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“…Here, we tested the hypothesis that changes in maternal behavior in mice would be contingent on the type of ELA experienced, directly comparing predictability of care in the limited bedding and nesting (LBN) and maternal separation (MS) paradigms. We then tested whether the predictability of the ELA environment altered the expression of corticotropin-releasing hormone (Crh), a sexually-dimorphic neuropeptide that regulates threat-related learning, in the amygdala of male and female mice. …”
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“…BACKGROUND: Current paradigms for predicting weight loss in response to energy restriction have general validity but a subset of individuals fail to respond adequately despite documented diet adherence. …”
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“…In recent years, many paradigms have been developed to manipulate and empirically investigate the object of consciousness. …”
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