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  1. 40881
    “…METHODS: Two different neural differentiation paradigms were used to investigate Npas4 expression during neurodevelopment in vitro; adherent monolayer differentiation of mouse ESCs in N2B27 medium and Noggin-induced differentiation of human ESCs. …”
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    A reduction in Npas4 expression results in delayed neural differentiation of mouse embryonic stem cells
  2. 40882
    “…Resistance exercise paradigms are often divided into high volume (HV) or high intensity (HI) protocols, however, it is unknown whether these protocols differentially stimulate mTORC1 signaling. …”
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    Intramuscular anabolic signaling and endocrine response following high volume and high intensity resistance exercise protocols in trained men
  3. 40883
    “…BACKGROUND: Rheumatoid arthritis (RA) treatment paradigms have shifted over the last two decades. There has been increasing emphasis on combination disease modifying anti-rheumatic drug (DMARD) therapy, newer biologic therapies have become available and there is a greater focus on achieving remission. …”
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    Changing clinical patterns in rheumatoid arthritis management over two decades: sequential observational studies
  4. 40884
    “…In addition, variable expression paradigms and outcomes hinder systematic comparison of toxicity profiles. …”
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    Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease
  5. 40885
    “…Therefore, this study compared the BTBR and C57Bl/6 wild-type and PKU mice on PKU-relevant amino acid- and neurotransmitter-levels and at a behavioral level. The behavioral paradigms were selected from previous literature on the PKU mouse model and address four domains, namely (1) activity levels, (2) motor performance, (3) anxiety and/or depression-like behavior, and (4) learning and memory. …”
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    The Behavioral Consequence of Phenylketonuria in Mice Depends on the Genetic Background
  6. 40886
    “…CONCLUSION: M. tuberculosis PJI can be controlled with prolonged antituberculosis treatment in most cases, with or without surgical treatment.This case series and literature review suggest that the paradigms for the management of M. tuberculosis PJI may differ from PJI related to other pathogens, for which surgery is required. …”
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    779. Mycobacterium tuberculosis Prosthetic Joint Infections: A Case Series and Literature Review
  7. 40887
    “…Improvements in treatment paradigms are needed, along with efforts to reduce orthopedic surgical site infections.…”
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    Predictors of Treatment Failure for Hip and Knee Prosthetic Joint Infections in the Setting of 1- and 2-Stage Exchange Arthroplasty: A Multicenter Retrospective Cohort
  8. 40888
    “…The questions encompass setting appropriate research questions; community engagement and consultation; research leadership and governance; community protocols; intellectual and cultural property rights; the collection and management of research material; Indigenous research paradigms; a strength-based approach to research; the translation of findings into policy and practice; benefits to participants and communities involved; and capacity strengthening and two-way learning. …”
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    Assessing the quality of health research from an Indigenous perspective: the Aboriginal and Torres Strait Islander quality appraisal tool
  9. 40889
    “…Future work should consider the implications of conservative response criterion in ASD for commonly used forced-choice psychophysical paradigms.…”
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    Elevated Thresholds for Light Touch in Children With Autism Reflect More Conservative Perceptual Decision-Making Rather Than a Sensory Deficit
  10. 40890
    “…Translational collaborations where patients with clinical suspicion of LMD undergo CSF sampling, NGS/ctDNA analysis, and PDX modeling are crucial in improving our understanding of this metastatic compartment and investigating novel treatment paradigms.…”
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    LPTO-04. GENERATION AND CHARACTERIZATION OF PATIENT-DERIVED PRECLINICAL MODELS FROM TUMOR CELLS ISOLATED FROM CEREBROSPINAL FLUID
  11. 40891
    “…BACKGROUND: The risk and recovery paradigms are the dominant frameworks informing forensic mental health services and have been the focus of increasing research interest. …”
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    Perceptions of procedural justice and coercion among forensic psychiatric patients: a study protocol for a prospective, mixed-methods investigation
  12. 40892
    “…Over the past years there is increasing interest in the value of new paradigms in Magnetic Resonance Imaging (MRI) and the potential of ultra-high field strength imaging in the diagnostic work-up of PD. …”
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    The TRACK-PD study: protocol of a longitudinal ultra-high field imaging study in Parkinson’s disease
  13. 40893
    “…However, high variability in results emerged, potentially due to logistic paradigms adopted. Here, we analyze stroke code admissions, hospitalizations, and stroke belt performance for ischemic stroke patients in the metropolitan Bologna region, comparing temporal trends between 2019 and 2020 to define the impact of COVID-19 on the stroke network. …”
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    The stroke mothership model survived during COVID-19 era: an observational single-center study in Emilia-Romagna, Italy
  14. 40894
    “…BACKGROUND: Nanotoxicology is an increasingly relevant field and sound paradigms on how inhaled nanoparticles (NPs) interact with organs at the cellular level, causing harmful conditions, have yet to be established. …”
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    Cobalt oxide nanoparticles induce oxidative stress and alter electromechanical function in rat ventricular myocytes
  15. 40895
    “…CONCLUSIONS: Changing treatment paradigms and early referral might have reduced mortality in COVID-19 patients. …”
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    Characteristics and outcomes in hospitalized COVID-19 patients during the first 28 days of the spring and autumn pandemic waves in Milan: An observational prospective study
  16. 40896
    “…The model generated predictions for regional EGFR amplification status (a common and important target in GBM) to resolve the intratumoral genetic heterogeneity across each individual tumor—a key factor for future personalized therapeutic paradigms. The model used probability distributions for each sample prediction to quantify uncertainty, and used transductive learning to reduce the overall uncertainty. …”
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    Uncertainty quantification in the radiogenomics modeling of EGFR amplification in glioblastoma
  17. 40897
    “…The use of non-human primates for preclinical studies exploring new treatment paradigms in SCI results in data with more translational relevance to human SCI. …”
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    Disease modifying treatment of spinal cord injury with directly reprogrammed neural precursor cells in non-human primates
  18. 40898
    “…In this review, current paradigms and state-of-the-art in mRNA-LNP vaccine development are explored through first highlighting advantages posed by mRNA vaccines, establishing LNPs as a biocompatible delivery system, and finally exploring the use of mRNA-LNP vaccines in vivo against infectious disease towards translation to the clinic. …”
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    From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases
  19. 40899
    “…EEG was recorded during two auditory Go/NoGo paradigms assessing the P300 and contingent negative variation (CNV). fNIRS measurements were conducted during an n-back- as well as a Go/NoGo task. …”
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    A randomized-controlled neurofeedback trial in adult attention-deficit/hyperactivity disorder
  20. 40900
    “…Recently established similarities between the aetiological hypotheses of depression and cardiometabolic diseases are shifting paradigms within this field. It is believed that dietary practices could potentially reduce the incidence of depression; similar to their effects on metabolism. …”
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    Healthy diet, depression and quality of life: A narrative review of biological mechanisms and primary prevention opportunities
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