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  1. 41141
    “…CONCLUSIONS: Our findings show that it is possible to obtain and analyze data from independent veterinary clinics in the US, an approach that could be useful for studies of comparative epidemiology under the One Health and One Welfare paradigms. We also show that the lifespan effects of gonadectomy are not identical between the sexes and should be investigated separately by sex in future analyses. …”
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    Lifespan of companion dogs seen in three independent primary care veterinary clinics in the United States
  2. 41142
    “…ETHNOPHARMACOLOGICAL RELEVANCE: Traditional pharmacopeias have been developed by multiple cultures and evaluated for efficacy and safety through both historical/empirical iteration and more recently through controlled studies using Western scientific paradigms and an increasing emphasis on data science methodologies for network pharmacology. …”
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    Medicine in motion: Opportunities, challenges and data analytics-based solutions for traditional medicine integration into western medical practice
  3. 41143
    “…This tool will be of benefit to services when reviewing practices internally, for mandatory external reviewing bodies and for future clinical research paradigms. SUPPLEMENTARY INFORMATION: Supplementary information accompanies this paper at 10.1186/s12888-020-02912-6.…”
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    A tool to evaluate proportionality and necessity in the use of restrictive practices in forensic mental health settings: the DRILL tool (Dundrum restriction, intrusion and liberty ladders)
  4. 41144
    “…Isologous seeding, where the sequence of the PrP in the seed matches that of the host, is generally much more efficient than when there is a sequence mis-match. Here, we used paradigms in which mutant SOD1 seeding homogenates were injected intraspinally in newborn mice or into the sciatic nerve of adult mice, to assess the influence of SOD1 primary sequence on seeding efficiency. …”
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    Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence
  5. 41145
    “…Different behavioral paradigms were used to evaluate long-term memory performance. …”
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    Selectively increasing GHS-R1a expression in dCA1 excitatory/inhibitory neurons have opposite effects on memory encoding
  6. 41146
    “…CONCLUSION: Individuals with EIB(alone) or EIB(asthma) demonstrate considerable morbidity. New treatment paradigms may be needed to optimize outcomes for both patient groups.…”
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    Demographics, Treatment Patterns, and Morbidity in Patients with Exercise-Induced Bronchoconstriction: An Administrative Claims Data Analysis
  7. 41147
    por Vogel, Felix, Schwenck, Christina
    Publicado 2021
    “…METHODS: We assessed in a total of N = 96 children [8–12 years, SM: n = 31, SAD: n = 32, typical development (TD): n = 33] resting baseline arousal in absence of social threat and the course of physiological fear response in two social stress paradigms, differing in terms of whether the children are expected to speak (verbal task) or not (nonverbal task). …”
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    Psychophysiological mechanisms underlying the failure to speak: a comparison between children with selective mutism and social anxiety disorder on autonomic arousal
  8. 41148
    por Ge, Tian, Irvin, Marguerite R., Patki, Amit, Srinivasasainagendra, Vinodh, Lin, Yen-Feng, Tiwari, Hemant K., Armstrong, Nicole D., Benoit, Barbara, Chen, Chia-Yen, Choi, Karmel W., Cimino, James J., Davis, Brittney H., Dikilitas, Ozan, Etheridge, Bethany, Feng, Yen-Chen Anne, Gainer, Vivian, Huang, Hailiang, Jarvik, Gail P., Kachulis, Christopher, Kenny, Eimear E., Khan, Atlas, Kiryluk, Krzysztof, Kottyan, Leah, Kullo, Iftikhar J., Lange, Christoph, Lennon, Niall, Leong, Aaron, Malolepsza, Edyta, Miles, Ayme D., Murphy, Shawn, Namjou, Bahram, Narayan, Renuka, O’Connor, Mark J., Pacheco, Jennifer A., Perez, Emma, Rasmussen-Torvik, Laura J., Rosenthal, Elisabeth A., Schaid, Daniel, Stamou, Maria, Udler, Miriam S., Wei, Wei-Qi, Weiss, Scott T., Ng, Maggie C. Y., Smoller, Jordan W., Lebo, Matthew S., Meigs, James B., Limdi, Nita A., Karlson, Elizabeth W.
    Publicado 2022
    “…Leveraging existing large-scale genome-wide association studies (GWAS), polygenic risk scores (PRS) have shown promise to complement established clinical risk factors and intervention paradigms, and improve early diagnosis and prevention of T2D. …”
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    Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations
  9. 41149
    “…Future HIV cure research paradigms should equitably include considerations from these groups. …”
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    “It comes altogether as one:” perceptions of analytical treatment interruptions and partner protections among racial, ethnic, sex and gender diverse HIV serodifferent couples in the United States
  10. 41150
    “…We will map the neural fingerprint for each participant using the following MRI modalities: T1‐weighted, diffusion-weighted, resting-state functional MRI, and multiple functional-MRI paradigms. With respect to the functional MRI measures, half of the sample will learn grammatical features and half will learn words of a new language. …”
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    Study protocol: a comprehensive multi-method neuroimaging approach to disentangle developmental effects and individual differences in second language learning
  11. 41151
    “…BACKGROUND: Integrated movement and cognitive load paradigms are used to expose impairments associated with concussion and musculoskeletal injury. …”
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    Changes in dual-task cognitive performance elicited by physical exertion vary with motor task
  12. 41152
    por HEKIMIAN, Stéphanie
    Publicado 2021
    “…Seulement, comme dans beaucoup d’institutions, les moyens de réaliser ces projets étaient limités et, en plein changement de paradigme, les bonnes pratiques de numérisation manquaient encore de recul. …”
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    L’évolution de contenus numérisés : le cas de la revalorisation des Yellow Reports du CERN
  13. 41153
    “…Participants were assessed at baseline and after 6 and 12 weeks using clinical and physical evaluations, self-rating questionnaires, and functional magnetic resonance imaging (fMRI) together with paradigms that tested attention, impulsivity and emotion regulation. …”
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    Feasibility and tolerability of moderate intensity regular physical exercise as treatment for core symptoms of attention deficit hyperactivity disorder: a randomized pilot study
  14. 41154
    “…Despite their precarious behavioral classification (histopathologically benign (low-grade), behaviorally malignant), great strides have been taken to improve prognostication and treatment paradigms for patients with skull base chordoma. However, due to the rarity of this tumor, prior investigations remain limited to small retrospective series. …”
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    SDPS-05 ASSESSING SURVIVAL OUTCOMES AND COMPLICATION PROFILES FOLLOWING SURGICAL EXCISION OF SKULL BASE CHORDOMA: A COMPREHENSIVE SYSTEMATIC REVIEW AND META-ANALYSIS
  15. 41155
    “…The characteristic radiological traits integrated into prognostic systems (arterial enhancement pattern, tumour boundary, and capsular retraction) were highly correlated with heterogeneous tumour-immune microenvironments, thereby renovating treatment paradigms for this difficult-to-treat disease.…”
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    Translating imaging traits of mass-forming intrahepatic cholangiocarcinoma into the clinic: From prognostic to therapeutic insights
  16. 41156
    “…BACKGROUND: Anti‐PD‐(L)1 agents have revolutionized the treatment paradigms of non‐small cell lung cancer (NSCLC), while predictive biomarkers are limited. …”
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    The prognostic and predictive roles of plasma C‐reactive protein and PD‐L1 in non‐small cell lung cancer
  17. 41157
    “…The risk associated with peri-hospitalization ICD placement did not differ by race and ethnicity. Future paradigms aimed at enhancing real-world effectiveness of ICD therapy and addressing disparate outcomes should consider timing and setting of ICD placement in HFrEF patients who otherwise meet guideline eligibility.…”
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    Racial differences in setting of implantable cardioverter-defibrillator placement in older adults with heart failure and association with disparate post-implant outcomes
  18. 41158
    “…METHODS: We conducted an analysis of the Optimizing Prehospital Stroke Systems of Care-Reacting to Changing Paradigms (OPUS-REACH) registry of 2,400 LVOS patients treated at nine ESCs in the United States. …”
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    A Shorter Door-In-Door-Out Time Is Associated with Improved Outcome in Large Vessel Occlusion Stroke
  19. 41159
    “…We designed an experimental task including a test tool to assess TD and Oddbal detection (OD) paradigms with a cognitive control component. The task was conducted under functional magentic resonance imaging (fMRI). …”
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    Time discrimination in psychosis: findings from a neuroimaging study
  20. 41160
    “…Methods: We applied the SHIRPA primary screen and specific neuromotor, behavioral, and cognitive paradigms. The spatiotemporal development of tau pathology was investigated immunohistochemically. …”
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    Behavioral and Neuropathological Phenotyping of the Tau58/2 and Tau58/4 Transgenic Mouse Models for FTDP-17
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