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  1. 7901
    “…In this experiment, we used the CORT paradigm to evaluate whether depression-like behavior is associated with similar changes in the pattern of SERT and 5HT2A membrane protein clustering as those observed in depression patients. …”
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    Changes in Membrane Protein Clustering in Peripheral Lymphocytes in an Animal Model of Depression Parallel Those Observed in Naïve Depression Patients: Implications for the Development of Novel Biomarkers of Depression
  2. 7902
    “…Additionally, this study demonstrates that the proposed new ambiguous paradigm is useful in studies concerning the influence of affect on decisions.…”
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    The N400/FN400 and Lateralized Readiness Potential Neural Correlates of Valence and Origin of Words’ Affective Connotations in Ambiguous Task Processing
  3. 7903
    “…These findings imply a need for a paradigm shift in the treatment of cervical AC patients. …”
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    Neo-adjuvant treatment of adenocarcinoma and squamous cell carcinoma of the cervix results in significantly different pathological complete response rates
  4. 7904
    por Uher, Jana
    Publicado 2018
    “…The Transdisciplinary Philosophy-of-Science Paradigm for Research on Individuals (TPS-Paradigm) is applied to explore psychological and social-science concepts of measurement and quantification, including representational measurement theory, psychometric theories and their precursors in psychophysics. …”
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    Quantitative Data From Rating Scales: An Epistemological and Methodological Enquiry
  5. 7905
    “…BACKGROUND: Recent discoveries in the fields of machine learning (ML), Ecological Momentary Assessment (EMA), computerized adaptive testing (CAT), digital phenotype, imaging, and biomarkers have brought about a new paradigm shift in medicine. OBJECTIVE: The aim of this study was to explore psychiatrists’ perspectives on this paradigm through the prism of new clinical decision support systems (CDSSs). …”
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    Psychiatrists' Attitudes Toward Disruptive New Technologies: Mixed-Methods Study
  6. 7906
    “…RESULTS: to comply with this new paradigm, we developed a seagrass growth model that updates the carrying capacities for biomass and shoot density from the seagrass IBL at each time step. …”
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    A model for the biomass–density dynamics of seagrasses developed and calibrated on global data
  7. 7907
    por De Loof, Arnold, Schoofs, Liliane
    Publicado 2019
    “…The high rotatable bond count, and their horseshoe-shape are instrumental to their valve function. In our paradigm, Met/Tai and Gce, to date generally thought to be the (only) functional (nuclear) receptors for JHs, are classified as probable Ca(2+)-sensitive transcription factors. …”
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    Mode of Action of Farnesol, the “Noble Unknown” in Particular in Ca(2+) Homeostasis, and Its Juvenile Hormone-Esters in Evolutionary Retrospect
  8. 7908
    “…Novel rapid-acting antidepressants, such as ketamine, may also constitute a paradigm shift in treatment optimization for MDD.…”
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    Prognosis and improved outcomes in major depression: a review
  9. 7909
    “…Genetic and pharmacological manipulations targeting metabotropic glutamate receptor 5 (mGluR5) affect performance in behavioural paradigms that depend on cognitive flexibility. Many of these studies involved exposing mice to highly stressful conditions including electric foot shocks or water immersion and forced swimming. …”
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    Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses
  10. 7910
    “…RESULTS: A revised definition of systems for CDP and seven attributes of effective systems for CDP are reported (collaborative capacity, health equity paradigm, leadership and governance, resources, implementation of desired actions, information and complex systems paradigm). …”
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    Strengthening complex systems for chronic disease prevention: a systematic review
  11. 7911
    “…However, conventional one-drug-one-gene drug discovery paradigm and emerging polypharmacology approach rarely tackle the challenge of multi-indication drug design. …”
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    Rational discovery of dual-indication multi-target PDE/Kinase inhibitor for precision anti-cancer therapy using structural systems pharmacology
  12. 7912
    por Knight, Daniel R., Riley, Thomas V.
    Publicado 2019
    “…Moreover, they challenge the existing paradigm and the long-held misconception that CDI is primarily a healthcare-associated infection. …”
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    Genomic Delineation of Zoonotic Origins of Clostridium difficile
  13. 7913
    por Geerts, Hugo, Barrett, James E.
    Publicado 2019
    “…This paper reviews the history of CNS drug Discovery over the last 60 years and proposes a new paradigm based on the lessons learned. The initial wave of successful therapeutics discovered using careful clinical observations was followed by an emphasis on a phenotypic target-agnostic approach, often leading to successful drugs with a rich pharmacology. …”
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    Neuronal Circuit-Based Computer Modeling as a Phenotypic Strategy for CNS R&D
  14. 7914
    “…The goal of this study was to compare neural activity and connectivity during a voluntary movement (VM) paradigm that involved cued eye blinks among children with and without CTDs. …”
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    Neural activation and connectivity during cued eye blinks in Chronic Tic Disorders
  15. 7915
    “…Mediation, considered to be a paradigm shift in the foreign language classroom and for different out-of-class language learning possibilities, could also provide an environment where learners maximize their emotional intelligence. …”
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    A Music-Mediated Language Learning Experience: Students’ Awareness of Their Socio-Emotional Skills
  16. 7916
    “…CONCLUSION: Incorporating DDPCR in the current clinical diagnostic paradigm has the potential to improve its cost-effectiveness and benefit.…”
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    Droplet digital polymerase chain reaction offers an improvisation over conventional immunohistochemistry and fluorescent in situ hybridization for ascertaining Her2 status of breast cancer
  17. 7917
    “…The study included 128-channel scalp Electroencephalogram (EEG) recordings during the P50 auditory paradigm for 35 unmedicated FESZ, 30 drug-free UHR, and 40 HC. …”
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    EEG-Based Brain Functional Connectivity in First-Episode Schizophrenia Patients, Ultra-High-Risk Individuals, and Healthy Controls During P50 Suppression
  18. 7918
    “…Prior studies have shown that neurological patients with hippocampal pathology have word-learning impairments, but this has not been tested in a statistical learning paradigm. Here, we used a neuropsychological approach to test whether patients with bilateral hippocampal pathology (N = 3) could learn new words in a CSSL paradigm. …”
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    Cross-Situational Statistical Learning of New Words Despite Bilateral Hippocampal Damage and Severe Amnesia
  19. 7919
    “…The functional MRI tasks include a self-evaluation paradigm and a self-disclosure paradigm. In addition, adolescents and their parents/guardians complete a number of surveys to report on the adolescent's pubertal development, mental health, social environment and life events; adolescents also report on various indices of self-perception and social-emotional functioning. …”
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    Study Protocol: Transitions in Adolescent Girls (TAG)
  20. 7920
    “…BACKGROUND: The current drug development paradigm has been criticized for being too drug-centered and for not adequately focusing on the patients who will eventually be administered the therapeutic interventions it generates. …”
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    Views of European Drug Development Stakeholders on Treatment Optimization and Its Potential for Use in Decision-Making
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