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  1. 8041
    “…In this review we focus on such novel strategies that have changed the treatment paradigm of this rare malignancy.…”
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    Novel therapeutic agents for cutaneous T-Cell lymphoma
  2. 8042
    “…In Michotte's launching paradigm a square moves up to and makes contact with another square, which then moves off more slowly. …”
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    The emotional effects of violations of causality, or How to make a square amusing
  3. 8043
    por Ohukainen, Pauli
    Publicado 2013
    “…This has been established as the current paradigm in both biomedical research as well as public health policies. …”
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    If the wheel ain’t broke, don’t reinvent it
  4. 8044
    por Hulkower, Keren I., Herber, Renee L.
    Publicado 2011
    “…With the advent of high-throughput and high content imaging systems, there has been a movement towards the use of physiologically relevant cell-based assays earlier in the testing paradigm. This allows more effective identification of lead compounds and recognition of undesirable effects sooner in the drug discovery screening process. …”
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    Cell Migration and Invasion Assays as Tools for Drug Discovery
  5. 8045
    “…We have recently developed an immunotherapeutic approach to target a major driver of EMT, the T-box transcription factor T (also known as brachyury). This therapeutic paradigm is currently being tested in patients with advanced carcinomas in the context of a Phase I clinical trial.…”
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    An immunotherapeutic intervention against tumor progression: Targeting a driver of the epithelial-to-mesenchymal transition
  6. 8046
    por Hydes, Theresa, Khakoo, Salim I.
    Publicado 2012
    “…This association is one of the strongest in anti-viral immunity and represents a paradigm shift in how we view the immune response to HCV infection.…”
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    Innate immunity: a new chapter for hepatitis C
  7. 8047
    por Jaju, Prashant P, Jaju, Sushma P
    Publicado 2014
    “…With the advent of cone-beam computed tomography, dental practice has seen a paradigm shift. This review article highlights the potential applications of cone-beam computed tomography in the fields of dental implantology and forensic dentistry, and its limitations in maxillofacial diagnosis.…”
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    Clinical utility of dental cone-beam computed tomography: current perspectives
  8. 8048
    “…Here, we summarize our current understanding of mutational patterns and mutational signatures in light of both the somatic cell paradigm of cancer research and the recent developments in the field of cancer genomics.…”
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    Mutational signatures: the patterns of somatic mutations hidden in cancer genomes()
  9. 8049
    “…This review article updates the hypothesis and paradigm of CSCs with a focus on major signaling pathways and effectors that regulate CSC apoptosis. …”
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    Apoptotic Death of Cancer Stem Cells for Cancer Therapy
  10. 8050
    por Liu, Zhaoqi, Zhang, Shihua
    Publicado 2014
    “…Pan-cancer study is becoming a valuable paradigm for cancer genomics. Here, we review recent advances in this field and highlight the potential challenges and directions especially from the computational angle.…”
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    Toward a systematic understanding of cancers: a survey of the pan-cancer study
  11. 8051
    por Liao, Yong
    Publicado 2013
    “…If this stem cell misplacement theory could withstand future experimental evaluation, it may provide a paradigm shift in the prevention and management of cancer in the clinic.…”
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    Cancer, stem cell misplacement and cancer stem cells
  12. 8052
    por Burgess, Neil
    Publicado 2014
    “…This prize recognizes both a paradigm shift in the study of cognitive neuroscience, and some of the amazing insights that have followed from it concerning how the world is represented within the brain.…”
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    The 2014 Nobel Prize in Physiology or Medicine: A Spatial Model for Cognitive Neuroscience
  13. 8053
    por Sun, Lin, Kanwar, Yashpal S.
    Publicado 2015
    “…An ancillary paradigm that has evolved recently in the pathogenesis of diabetic nephropathy includes subclinical “micro-inflammation” with influx of macrophages and consequential generation of myriad pro-inflammatory cytokines and ensuing kidney damage. …”
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    RELEVANCE OF TNF-α IN THE CONTEXT OF OTHER INFLAMMATORY CYTOKINES IN THE PROGRESSION OF DIABETIC NEPHROPATHY
  14. 8054
    “…Recent advances in endoscopic therapy for early Barrett’s cancers have shifted the paradigm away from oesophagectomy and have yielded excellent results.…”
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    Advances in the endoscopic diagnosis and treatment of Barrett’s neoplasia
  15. 8055
    por Tenenbaum, Jessica D.
    Publicado 2016
    “…Development of high-throughput technologies and electronic health records has caused a paradigm shift in both healthcare and biomedical research. …”
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    Translational Bioinformatics: Past, Present, and Future
  16. 8056
    por Kocoglu, Mehmet, Badros, Ashraf
    Publicado 2016
    “…We, for the second time in the last two decades, are about to witness another shift of the paradigm in the management of this ailment. This review will summarize the major approaches in myeloma immunotherapies.…”
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    The Role of Immunotherapy in Multiple Myeloma
  17. 8057
    “…[Image: see text] Single-electron transmetalation has emerged as an enabling paradigm for the cross-coupling of C(sp(3)) hybridized organotrifluoroborates. …”
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    Photoredox Cross-Coupling: Ir/Ni Dual Catalysis for the Synthesis of Benzylic Ethers
  18. 8058
    “…In this interview we have the chance to talk with Lucas Albert Charles Derks, founder of the International Laboratory for Mental Space Research and of the Society for Mental Space Psychology and the creator of the Social Panorama approach, about the paradigm that evolved in the last 25 years, entitled Mental Space Psychology, with roots from Cognitive Linguistics, Spatial Cognition and Neuroscience. …”
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    On the Emergence of Mental Space in Psychology: Interview With Lucas Albert Charles Derks
  19. 8059
    “…Human papillomavirus (HPV)-induced neoplasms have long been considered to originate from viral infection of the basal cell layer of the squamous mucosa. However, this paradigm has been recently undermined by accumulating data supporting the critical role of a discrete population of squamo-columnar (SC) junction cells in the pathogenesis of cervical (pre)cancers. …”
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    Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis
  20. 8060
    por Leipzig, Jeremy
    Publicado 2017
    “…Modern implementations of these frameworks differ on three key dimensions: using an implicit or explicit syntax, using a configuration, convention or class-based design paradigm and offering a command line or workbench interface. …”
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    A review of bioinformatic pipeline frameworks
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