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  1. 8061
    “…The advent of microincisional vitrectomy systems (MIVS) has created a paradigm shift away from twenty-gauge vitrectomy systems, which have been the gold standard in the surgical management of vitreoretinal diseases for over thirty years. …”
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    Review of Small Gauge Vitrectomy: Progress and Innovations
  2. 8062
    por Kapoor, Kapil G., Sim, Jennifer
    Publicado 2017
    “…This challenge-rechallenge case may be helpful to clinicians in delineating a treatment paradigm for these patients.…”
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    Spironolactone for Secondary Central Serous Chorioretinopathy: A Challenge-Rechallenge Case
  3. 8063
    “…The rapid proliferation of connectivity, availability of ubiquitous computing, miniaturization of sensors and communication technology, have changed healthcare in all its areas, creating the well-known healthcare paradigm of e-Health. In this paper, an embedded system capable of monitoring, learning and classifying biometric signals is presented. …”
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    An Associative Memory Approach to Healthcare Monitoring and Decision Making
  4. 8064
    “…The paradigm for the diagnosis and management of gastric cancer is changing with advanced diagnostic and therapeutic interventions. …”
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    Atypical Presentation of Gastric Cancer Approached Via Retrograde Single Balloon Enteroscopy
  5. 8065
    “…Using a collaborative leadership model, an HBCU changed its teaching and learning paradigm to significantly broaden participation in STEM.…”
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    Transforming STEM Education through Collaborative Leadership at Historically Black Colleges and Universities
  6. 8066
    “…In this brief review, we introduce a new paradigm—inflamm-inactivity—that describes a potent counter-measure to age-associated inflammatory illness.…”
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    Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity?
  7. 8067
    por Samavedam, Srinivas
    Publicado 2019
    “…Neurocritical care is an ever growing specialty with paradigm changes being the norm. Some of the established practices like triple H therapy for SAH and steroids in pyogenic meningitis have seen major changes in published evidence. …”
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    Ten Papers that Changed My Practice in Neurocritical Care
  8. 8068
    “…The mechanisms associated with this paradigm remain not clearly defined. However, loss of virological control, morbidity and mortality persist in these individuals, such as progress to AIDS-defining conditions together with persistent high rate of immune activation. …”
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    HIV-1 elite controllers: an immunovirological review and clinical perspectives
  9. 8069
    “…They believe that AC represents a paradigm for personalised medicine in cardiology and that better stratification of the disease will enhance the development of mechanism-based treatments.…”
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    Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype?
  10. 8070
    “…Vehicular sensor networks (VSN) provide a new paradigm for transportation technology and demonstrate massive potential to improve the transportation environment due to the unlimited power supply of the vehicles and resulting minimum energy constraints. …”
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    Vehicular Sensor Networks: Applications, Advances and Challenges
  11. 8071
    “…We propose use of bispecific monoclonal antibody (mAb) complexes bound to erythrocytes to redress the lack of efficacy of anti‐amyloid beta mAbs in Alzheimer's disease treatment. Our paradigm leverages erythrocyte complement receptor 1 to promote rapid and quantitative removal of amyloid beta from the circulation, and its subsequent removal from the brain as well.…”
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    Clearance of amyloid‐beta with bispecific antibody constructs bound to erythrocytes
  12. 8072
    “…Crops such as olive tree, whose management is more and more frequently based on the paradigm of sustainable agriculture, are particularly interested in the perspective of a possible applicative employment, considering that the multi-year crop cycle implies a likely higher impact of these symbiotic interactions. …”
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    Endophytic Fungi of Olive Tree
  13. 8073
    por Shin, Jungsu, Ko, Jaewon
    Publicado 2021
    “…Here, we describe a detailed procedure for using this paradigm in mice that relies on reward-based mutual communication that is automatically detected by a software algorithm embedded in the custom-made equipment. …”
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    Protocol for quantitative assessment of social cooperation in mice
  14. 8074
    por Stockinger, Brigitta
    Publicado 2021
    “…From their identification as a distinct subset, they quickly became the paradigm for the astonishing plasticity that CD4 T cells can exhibit depending on tissue environment and circumstances.…”
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    Lumpers and splitters: Birth of Th17 cells
  15. 8075
    “…Super-resolution microscopy (SRM) has been widely adopted to probe molecular distribution at excitatory synapses. We present an SRM paradigm to evaluate the nanoscale organization heterogeneity between neuronal subcompartments. …”
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    Quantifying molecular aggregation by super resolution microscopy within an excitatory synapse from mouse hippocampal neurons
  16. 8076
    “…In ischemic cardiomyopathy, endocardial reentry has traditionally been the mechanistic paradigm for understanding ventricular tachycardia (VT). …”
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    Epicardial–Endocardial Reentry in Ischemic Cardiomyopathy
  17. 8077
    Publicado 2021
    “…Maria Losada-Perez is first author on ‘ A novel injury paradigm in the central nervous system of adult Drosophila: Molecular, cellular and functional aspects’, published in DMM. …”
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    First person – Maria Losada-Perez
  18. 8078
    “…However, the complexity of applying a robust environmental enrichment paradigm makes clinical use difficult. Accordingly, there has been increased interest in developing environmental enrichment mimetics, also known as enviromimetics. …”
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    Environmental Enrichment and Its Benefits for Migraine: Dendritic Cell Extracellular Vesicles as an Effective Mimetic
  19. 8079
    “…Comprehensive characterization of the molecular profile and of the tumor immune microenvironment of GC has allowed researchers to explore promising biomarkers for GC treatment and has enabled a new paradigm in precision-targeted immunotherapy. In this article, we review established and promising new biomarkers relevant in GC, with a focus on their clinical implications, diagnostic methods, and the efficacy of targeted agents.…”
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    Gastric Cancer: Mechanisms, Biomarkers, and Therapeutic Approaches
  20. 8080
    “…We detail a mitochondrial-damaging assay, a SNAP pulse-chase labeling paradigm, and live imaging to visualize the mitochondrial network. …”
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    Fluorescent pulse-chase labeling to monitor long-term mitochondrial degradation in primary hippocampal neurons
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