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  1. 8121
    por Needleman, H L
    Publicado 1990
    “…The history of knowledge about lead toxicity may serve as a useful template to judge and predict progress in understanding other toxicants. A paradigm shift has occurred in which toxicity has been recognized at levels long held to be harmless. …”
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    What can the study of lead teach us about other toxicants?
  2. 8122
    por Whitworth, Judith A
    Publicado 2005
    “…In parallel, there has been a paradigm shift from a single risk factor approach to comprehensive cardiovascular disease risk prevention. …”
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    Blood Pressure and Control of Cardiovascular Risk
  3. 8123
    “…Surprisingly, cellular toxicity is often due not to the highly-ordered aggregates but to the oligomers that precede their formation. Using serpins as a paradigm, we show how the active and infective interface of oligomers is inherently toxic and can promiscuously bind to unrelated peptides, including neurotransmitters. …”
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    Serpins show structural basis for oligomer toxicity and amyloid ubiquity
  4. 8124
    “…OBJECTIVE: To examine its role in emotional modulation of attention, we used an attentional blink (AB) paradigm, in the context of psychopharmacological manipulation, where targets were either emotional or neutral items. …”
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    Noradrenergic neuromodulation of human attention for emotional and neutral stimuli
  5. 8125
    por Katsanis, Nicholas
    Publicado 2009
    “…These new realities will probably necessitate a paradigm shift in our approach to complex traits, for which the combinatorial application of genomic and functional studies will be necessary to understand the mechanism and pathology of genetic disease. …”
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    From association to causality: the new frontier for complex traits
  6. 8126
    por Sinibaldi, Victoria J
    Publicado 2007
    “…This discovery changed the perceptions about utilization of chemotherapy for this devastating disease and introduced a new paradigm/standard of care treatment for this patient population. …”
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    Docetaxel treatment in the elderly patient with hormone refractory prostate cancer
  7. 8127
    “…The current study explored whether inhibitory control deficits in high functioning autism (HFA) emerged when socially relevant stimuli were used and whether arousal level affected the performance. A Go/NoGo paradigm, with socially relevant stimuli and varying presentation rates, was applied in 18 children with HFA (including children with autism or Asperger syndrome) and 22 typically developing children (aged 8–13 years). …”
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    Brief Report: Inhibitory Control of Socially Relevant Stimuli in Children with High Functioning Autism
  8. 8128
    “…Previous work has documented that the direction of eye and hand movements can be adaptively modified using the double-step paradigm. Here we report that both motor systems adapt not only to small direction steps (5° gaze angle) but also to large ones (28° gaze angle). …”
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    Adaptation of eye and hand movements to target displacements of different size
  9. 8129
    por Nunez, Joseph
    Publicado 2008
    “…Morris in 1984, this paradigm has become one of the "gold standards" of behavioral neuroscience.…”
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    Morris Water Maze Experiment
  10. 8130
    “…In this paper, we review the medical imaging modalities available and a paradigm for choosing a particular imaging technique. …”
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    Image-guided tissue engineering
  11. 8131
    “…In this bioinformation, we discuss the mechanism of evolution of a new HxNy strain and the essential criteria for potentially breaking the outbreak of these extremely harmful and rapidly evolving viral strains in the near future by taking the recent H1N1 pandemic as a classical paradigm.…”
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    Breaking the HxNy outbreak
  12. 8132
    por Panda, Arabind
    Publicado 2010
    “…The dogma of tradition has perhaps failed to consider the paradigm shifts in the science. A system that was relevant 50 years ago may not be so relevant today. …”
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    For post-graduation in urology: Is a preliminary degree in general surgery necessary?
  13. 8133
    por Blobel, Bernd
    Publicado 2011
    “…Starting with the paradigm change of health systems towards personalized health services, the paper introduces the technical paradigms to be met for enabling ubiquitous pHealth including ePathology. …”
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    Intelligent security and privacy solutions for enabling personalized telepathology
  14. 8134
    “…Assisting patients to self-manage their chronic conditions and paying attention to unhealthy community factors could be added to EBM to create a broader paradigm of evidence-based health. A perspective of evidence-based health may encourage physicians to consider their role in upstream efforts to combat socially patterned chronic disease.…”
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    Moving from Evidence-Based Medicine to Evidence-Based Health
  15. 8135
    “…Our traditional understanding of the T-helper (Th)1/Th2 paradigm in periodontal disease has undergone considerable changes in recent years. …”
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    T-helper cells in the etiopathogenesis of periodontal disease: A mini review
  16. 8136
    “…44 subjects with Obsessive compulsive disorder (OCD) and 40 normals were compared using an experimental paradigm involving recording of the bereitschaftspotential. …”
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    OBSESSIVE COMPULSIVE DISORDER: IS IT A PROBLEM OF COMPLEX MOTOR PROGRAMMING?*
  17. 8137
    “…Ventilator-induced lung injury (VILI) consists of tissue damage and a biological response resulting from the application of inappropriate mechanical forces to the lung parenchyma. The current paradigm attributes VILI to overstretching due to very high-volume ventilation (volutrauma) and cyclic changes in aeration due to very low-volume ventilation (atelectrauma); however, this model cannot explain some research findings. …”
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    Beyond volutrauma in ARDS: the critical role of lung tissue deformation
  18. 8138
    “…CHAPTER SUMMARY: Systemic lupus erythematosus (SLE) is the paradigm of a multisystem autoimmune disease in which genetic factors strongly influence susceptibility. …”
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    Susceptibility genes in the pathogenesis of murine lupus
  19. 8139
    “…Moreover, the traditional full frame processing hardware and programming methodology has to be changed, as a part of this biomimetic approach, to a new processing paradigm based on pixel processing in a data flow manner, instead of full frame image processing.…”
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    Selective Change Driven Imaging: A Biomimetic Visual Sensing Strategy
  20. 8140
    por Oh, Bryan C, Holcomb, John B
    Publicado 2011
    “…Currently, the optimum fluid resuscitation paradigm for patients with both severe traumatic brain injury and other injuries requiring significant volume resuscitation is not clear.…”
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    Traumatic brain injury and resuscitation with blood products: what should we do?
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