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8161por Navin, Nicholas E“…The study of single cancer cells has transformed from qualitative microscopic images to quantitative genomic datasets. This paradigm shift has been fueled by the development of single-cell sequencing technologies, which provide a powerful new approach to study complex biological processes in human cancers.…”
Publicado 2014
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8162por Brun-Buisson, Christian“…The current paradigm for antibiotic management in critically ill patients is to initiate broad-spectrum therapy followed by de-escalation based on microbiological results. …”
Publicado 2014
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8163“…Here we discuss some of the molecular probes that illustrate this shift from a “one compound, one gene” paradigm to a more integrated approach to cell biology.…”
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8164“…This motif represents a new paradigm for what determines directional cell migration.…”
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8165por Johnson, S. L., Khiani, A., Bishop-Lilly, K. A., Chapman, C., Patel, M., Verratti, K., Teshima, H., Munk, A. C., Bruce, D. C., Han, C. S., Xie, G., Davenport, K. W., Chain, P., Sozhamannan, S.“…Each isolate has only a single chromosome, as opposed to the normal paradigm of two chromosomes found in all other V. cholerae isolates.…”
Publicado 2015
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8166por Cutkosky, Mark R.“…Bioinspiration is an increasingly popular design paradigm, especially as robots venture out of the laboratory and into the world. …”
Publicado 2015
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8167“…In this review, an overview of the lncRNAs modes of action, as well as the important and diversified roles of lncRNAs in immunity, are provided, and an emerging paradigm of lncRNAs in regulating innate immune responses is highlighted.…”
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8168por Decker, Thomas“…The canonical paradigm of Jak‐STAT signaling is that members of the signal transducers and activators of transcription (STATs) family of transcription factors are activated by Janus kinase (Jak)‐mediated tyrosine phosphorylation. …”
Publicado 2016
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8169por Rodrigo, Guillermo, Prakash, Satya, Cordero, Teresa, Kushwaha, Manish, Jaramillo, Alfonso“…Our work highlights that antisense small RNAs can work as regulatory agents beyond the antisense paradigm and that, hence, they could be interfaced with other circuits used in synthetic biology.…”
Publicado 2016
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8170por Pal, Ranabir, Kumar, Raman, Pal, Shrayan, Vidyasagar, Mukherji, Bijay, Debabrata, Sarbapalli“…So, the age-old traditional courses and curriculums in Indian medical education need a overhauling with radical modifications. With a paradigm shift, we have to take into account not only the help of scientific feedback from the teachers and students but also from all the stakeholders of health care delivery system.…”
Publicado 2016
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8171por Polo, Alfredo“…New optimized protocols are needed and should be tested in controlled trials, to demonstrate an advantage of such a new paradigm.…”
Publicado 2009
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8172por García-Sancho, Miguel“…Finally, I discuss the emergence of systems biology as an alternative paradigm.…”
Publicado 2006
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8173“…Our aim in this update is to discuss new advances in HAE therapy, focusing mainly on the various treatment options that have become available recently and also drugs that are under trial for prophylaxis to prevent attacks. There is a paradigm shift to where the treatment of HAE is headed, focusing now on prophylactic treatment rather than abortive management.…”
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8174“…Microbiome sequencing allows defining clusters of samples with shared composition. However, this paradigm poorly accounts for samples whose composition is a mixture of cluster-characterizing ones and which therefore lie in between them in the cluster space. …”
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8175“…This review will discuss the development of immunotherapies within this paradigm using emerging approaches being investigated in phase I/II trials in children with refractory brain tumors, including checkpoint inhibitors, vaccine immunotherapy, and adoptive cell therapy.…”
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8176por Bugnyar, Thomas“…A recent study by Krupenye, Kano, Hirata, Call, and Tomasello (Science, 354, 110–114, 2016) shows that great apes pass a false-belief task when they are tested with an anticipatory-looking paradigm developed for nonverbal human infants.…”
Publicado 2017
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8177por Bae, Jong-Myon“…As the paradigm in healthcare nowadays is the evidence-based, patient-centered decision making, the issue of shared decision making (SDM) is highlighted. …”
Publicado 2017
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8178“…Ecological landscape networks represent the current paradigm for the protection of biodiversity. In the analysis of land features that precedes the establishment of land management plans, graph-theoretic approaches become increasingly popular due to their aptness for the representation of connectivity. …”
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8179“…Intelligent Transportation Systems are an important enabler for the smart cities paradigm. Currently, such systems generate massive amounts of granular data that can be analyzed to better understand people’s dynamics. …”
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8180“…The ability to harness immune cells, engineer them and educate them to target cancer cells has changed the paradigm for treating non-Hodgkin’s lymphomas (NHL) and acute lymphoblastic leukemia (ALL). …”
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