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  1. 8401
    “…Early detection can aid in making a paradigm shift from a surgical to a more conservative approach for the management of such pregnancies. …”
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    Successful Non-surgical Management of Cesarean Scar Pregnancy
  2. 8402
    “…Retinitis pigmentosa, defined more properly as cone–rod dystrophy, is a paradigm of inherited diffuse retinal dystrophies, one of the rare diseases with the highest prevalence in the worldwide population and one of the main causes of low vision in the pediatric and elderly age groups. …”
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    The New Era of Therapeutic Strategies for the Treatment of Retinitis Pigmentosa: A Narrative Review of Pathomolecular Mechanisms for the Development of Cell-Based Therapies
  3. 8403
    por Hankey, Alex
    Publicado 2005
    “…If successfully developed, these ideas could result in a major paradigm shift in both biology and medicine, which will benefit all interested parties—consumers, health professionals, scientists, institutions and governments.…”
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    CAM Modalities Can Stimulate Advances in Theoretical Biology
  4. 8404
    “…Despite bilateral breast cancer being a rare clinical entity compared to unilateral breast cancer, both share a treatment paradigm of breast-conserving therapy for limited disease and metastasis direct therapy for oligometastatic disease. …”
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    Mind the Gap: Recurrence of Oligometastatic Breast Invasive Ductal Carcinoma in the Sternal Gap of Two Tangential Photon Fields of Bilateral Whole Breast Irradiation a Decade Later
  5. 8405
    “…Biomedical knowledge graphs (BKGs) provide a new paradigm for managing abundant biomedical knowledge efficiently. …”
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    Protocol to implement a computational pipeline for biomedical discovery based on a biomedical knowledge graph
  6. 8406
    “…[Image: see text] Programmable biomolecule-mediated computing is a new computing paradigm as compared to contemporary electronic computing. …”
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    Programmable Biomolecule-Mediated Processors
  7. 8407
    por Greenberg, Charles J
    Publicado 2005
    “…Like the stubborn spring dandelion that needs but a small crack in the sidewalk to flower boldly, the first flowers of Open Access in library literature, including Biomedical Digital Libraries, have sensed their opportunity to change the existing paradigm of giving away our scholarship and intellectual property, only to buy it back for the privilege of knowing it can be read. …”
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    Good old days?
  8. 8408
    por Ahmed, Niyaz
    Publicado 2005
    “…The Nobel committee at the Karolinska Institute of Sweden has selected this paradigm shift discovery of 1982 as the most impacting in medical sciences. …”
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    23 years of the discovery of Helicobacter pylori: Is the debate over?
  9. 8409
    por Sexton, K
    Publicado 1995
    “…Particular emphasis is given to examining the interrelationships among facts (science), judgments (science policy), and policy (values) in the context of the risk assessment paradigm. Science and policy are discussed in relation to Title III, contrasting the political consensus for action with the scientific uncertainty about risks and benefits. …”
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    Science and policy in regulatory decision making: getting the facts right about hazardous air pollutants.
  10. 8410
    por Waller, C L, Minor, D L, McKinney, J D
    Publicado 1995
    “…We used comparative molecular field analysis (CoMFA), a three-dimensional quantitative structure-activity relationship (QSAR) paradigm, to examine the underlying structural properties of ortho-chlorinated hydroxybiphenyl analogs known to bind to the estrogen receptor. …”
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    Using three-dimensional quantitative structure-activity relationships to examine estrogen receptor binding affinities of polychlorinated hydroxybiphenyls.
  11. 8411
    “…However, functional imaging with integrated IWC and FDG-PET provide more accurate response assessment, and challenge the current paradigm. Although integration of FDG-PET in IWC requires validation in a prospective trial with a large number of patients, new long-term clinical and therapeutic trials probably need to be designed using these new and hopefully standardized functional criteria. …”
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    Quantitative CT analysis for assessing response in lymphoma (Cheson’s criteria): Wednesday 5 October 2005, 08:30–10:00
  12. 8412
    “…Biological systems display a functional diversity, density and efficiency that make them a paradigm for synthetic systems. In natural systems, the cell is the elemental unit and efforts to emulate cells, their components, and organization have relied primarily on the use of bioorganic materials. …”
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    Nano-enabled synthetic biology
  13. 8413
    por Sichardt, Kathrin, Nieber, Karen
    Publicado 2007
    “…Using adenosine A(1) receptors as a paradigm of G protein-coupled receptors, this review focuses on how receptor-receptor interactions may contribute to regulation of the synaptic transmission within the central nervous system. …”
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    Adenosine A(1) receptor: Functional receptor-receptor interactions in the brain
  14. 8414
    por Fox Keller, Evelyn, Harel, David
    Publicado 2007
    “…Our proposal of a genetic functor, or genitor, is a sweeping extension of the classical genotype/phenotype paradigm, yet it appears to be faithful to the findings of contemporary biology, encompassing many of the recently emerging—and surprisingly complex—links between structure and functionality.…”
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    Beyond the Gene
  15. 8415
    por Lemichez, Emmanuel, Boquet, Patrice
    Publicado 2003
    “…Diphtheria toxin (DT) is the paradigm of the powerful A-B toxins. These bacterial poisons bind to cells, are endocytosed, and inject their catalytic domain into the cytosol causing the irreversible modification of a key component of the the host cellular machinery. …”
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    To be helped or not helped, that is the question
  16. 8416
    “…Emigration of leukocytes from the circulation into tissue by transendothelial migration, is mediated subsequently by adhesion molecules such as selectins, chemokines and integrins. This multistep paradigm, with multiple molecular choices at each step, provides a diversity in signals. …”
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    Leukocyte migration in experimental inflammatory bowel disease
  17. 8417
    “…As regards these carry-over effects, the present paradigm enabled us to demonstrate the influence of both persisting activation and persisting inhibition on the performance in switch trials.…”
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    Mixing costs and switch costs when switching stimulus dimensions in serial predictions
  18. 8418
    “…We have developed a novel paradigm to quantify habituation of the olfactory jump reflex in Drosophila. …”
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    Olfactory Jump Reflex Habituation in Drosophila and Effects of Classical Conditioning Mutations
  19. 8419
    por The Plant Ontology Consortium
    Publicado 2002
    “…The Plant Ontology(™) Consortium is expanding the paradigm of the Gene Ontology(™) Consortium (http://www.geneontology.org). …”
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    The Plant Ontology(™) Consortium and Plant Ontologies
  20. 8420
    por Gollery, Martin
    Publicado 2003
    “…As hidden Markov models (HMMs) become increasingly more important in the analysis of biological sequences, so too have databases of HMMs expanded in size, number and importance. While the standard paradigm a short while ago was the analysis of one or a few sequences at a time, it has now become standard procedure to submit an entire microbial genome. …”
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    Specialized Hidden Markov Model Databases for Microbial Genomics
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